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Sun, Jul 20, 2025

European Hematology Association

Home » Topics » Conferences » European Hematology Association
  • Leukemia
    June 25, 2025

    Rgenta’s RGT-61159 shows promise for MYB-expressing cancers

    MYB is an oncogenic transcription factor that is often aberrantly expressed in hematologic malignancies, mostly in acute myeloid leukemia (AML). Rgenta Therapeutics Inc. recently presented data for RGT-61159, a potent and selective MYB inhibitor compound that demonstrated cell killing across a panel of MYB-overexpressing leukemic cell lines.
  • Leukemia lymphoma blood cancer
    June 23, 2025

    APG-5918 shows potent activity against T-cell lymphoma

    Therapies against aggressive T-cell lymphomas (TCLs) are limited and treatment resistance to histone deacetylase (HDAC) inhibitors often occurs. Polycomb protein EED is a key member of the polycomb repressive complex 2 (PRC2) complex and is an attractive therapeutic target for TCLs. APG-5918 is an EED inhibitor from Ascentage Pharma Group International Co. Ltd. that has been proven to disrupt the PRC2 functioning and has been tested in preclinical TCL models as a promising approach.
  • Multiple myeloma bone
    June 20, 2025

    COG5 unveiled as a therapeutic target in multiple myeloma

    Multiple myeloma bone disease (MBD) lacks effective biomarkers; recent evidence involves exosomal circRNAs in the progression of cancer, but their roles in the field have not been deeply explored. The aim of this study was to explore the role of component of oligomeric golgi complex 5 (COG5) and shed light on its osteolytic mechanism.
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