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Sun, Jul 27, 2025

New compound

Home » Topics » Science » New compound
  • Endocrine thyroid antibodies
    July 21, 2025

    Crinetics’ TSHR antagonist demonstrates efficacy in thyroid autoimmune disorders

    Graves disease (GD)-associated hyperthyroidism is an autoimmune disorder characterized by the presence of autoantibodies that stimulate the thyroid-stimulating hormone receptor (TSHR), leading to excessive production of thyroid hormones.
  • Targeted cancer cell
    July 10, 2025

    First dual SHP2/FGFR inhibitor demonstrates potent preclinical antitumor activity

    Targeting SHP2 has emerged as a promising approach for treating cancers driven by receptor tyrosine kinases. Although allosteric SHP2 inhibitors have shown strong antitumor activity in preclinical studies, their clinical efficacy as monotherapies has been limited. Recent studies indicate that combining SHP2 inhibitors with kinase inhibitors may enhance treatment effectiveness and help overcome therapeutic resistance.
  • Woman and 3d brain
    July 9, 2025

    [68Ga]STZL-730 is promising approach for imaging of neuroinflammation

    Neuroinflammation is a common hallmark in several neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, among others, where TREM2 (triggering receptor expressed on myeloid cells 2) is a crucial member involved in this biological process and is mainly expressed in microglial cells, being thus an attractive target for diagnostic imaging.
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