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Breaking News: Trump administration impacts continue to roil the life sciences sectorSee today's BioWorld Science
Home » Antibody shows potential in thrombotic thrombocytopenic purpura
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Cardiovascular

Antibody shows potential in thrombotic thrombocytopenic purpura

July 8, 2024
Von Willebrand factor (vWF) plays a crucial role in hemostasis, and elevated levels are associated with risk of thrombosis. Gain-of-function mutations in the C-domain of vWF are linked to an increased risk of thrombosis. Previous work has shown that disrupting cysteine-rich C-domain in vWF led to reduced platelet recruitment in a shear-dependent fashion, making it a promising target for pharmacology. Apollo Therapeutics Ltd. has presented data on antibodies targeting the C-domain of vWF, including AP-21 as antithrombotics.
BioWorld Science Conferences International Society on Thrombosis and Haemostasis Cardiovascular Hematologic

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