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BioWorld - Saturday, May 10, 2025
Home » HIV

Articles Tagged with ''HIV''

HIV/AIDS

Merck Sharp & Dohme describes new Gag polyprotein (HIV-1)/protein Pol dimerization inducers

Feb. 6, 2025
Merck Sharp & Dohme LLC has identified targeted activator of cell kill (TACK) compounds acting as Gag polyprotein (HIV-1)/protein Pol dimerization inducers reported to be useful for the treatment of HIV infection.
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HIV/AIDS

Fox Chase Chemical Diversity Center, Univ. of Pittsburgh prepare new HIV-1 Nef degraders

Jan. 17, 2025
Fox Chase Chemical Diversity Center Inc. and University of Pittsburgh have jointly described new proteolysis targeting chimeras (PROTACs) consisting of Nef (HIV-1)-targeting moiety covalently linked to cereblon (CRBN)-binding moiety.
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Year in review 2024 - US lawsuits

Year’s top US court cases to present new challenges for 2025

Dec. 24, 2024
By Mari Serebrov
As if the uncertainties surrounding an incoming administration weren’t enough, a landmark U.S. Supreme Court decision and a potential new avenue of liability for drug and device manufacturers could bring an added level of unpredictability to the sector for 2025.
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Drug importation scheme adds to pressure for US PBM reforms

Dec. 24, 2024
By Mari Serebrov
Even though pharmacy benefit manager (PBM) reforms were dropped from the continuing resolution that was signed into law Dec. 21 to keep the U.S. government fully functional through March 14, the incoming administration and Congress likely will continue to try to rein in the PBMs, which serve as middlemen in the nation’s drug supply chain.
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Year in review 2024 - US lawsuits

Year’s top US court cases to present new challenges for 2025

Dec. 23, 2024
By Mari Serebrov
As if the uncertainties surrounding an incoming administration weren’t enough, a landmark U.S. Supreme Court decision and a potential new avenue of liability for drug and device manufacturers could bring an added level of unpredictability to the sector for 2025.
Read More
HIV/AIDS

A novel class of HIV-1 antivirals that target the HIV-1 capsid to inhibit nuclear import

Dec. 13, 2024
Antiretroviral therapy effectively suppresses HIV viral loads to undetectable levels but cannot eliminate the integration of viral DNA into the host cell genome.
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Jury convicts biotech execs in fraud scheme

Dec. 11, 2024
By Mari Serebrov
Nearly three years after being terminated as president and CEO of Cytodyn Inc., Nader Pourhassan was convicted June 9 by a U.S. federal jury for his role in a securities fraud scheme to deceive investors about the Vancouver, Wash.-based company’s development of leronlimab. The jury also convicted Kazem Kazempour, the CEO of Amarex Clinical Research LLC, a contract research organization hired by Cytodyn, for his part in the scheme.
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Lab mouse
HIV/AIDS

Humanized mouse model for evaluating SIV, HIV therapies

Dec. 9, 2024

In a recent publication, researchers from Colorado State University presented the development and evaluation of humanized mice as a hybrid dual-use model for testing therapeutics against both HIV and SIV infections.


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HIV/AIDS

Bivalent SMAC mimetic APG-1387 attacks HIV dormancy

Dec. 5, 2024
Researchers have described the ability of dasminapant (APG-1387) to decrease viral rebound in latent HIV infection models.
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Counterfeiter ordered to pay Gilead millions in restitution

Nov. 27, 2024
The U.S. District Court for the Northern District of California ordered Lorik Papyan, who pleaded guilty three years ago to one count of unlicensed wholesale distribution of prescription drugs, to pay Gilead Sciences Inc. nearly $32 million in restitution to cover lost profits due to a counterfeit HIV drug scheme he was involved in.
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