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Home » amyotrophic lateral sclerosis

Articles Tagged with ''amyotrophic lateral sclerosis''

ALS well that ends with a cure; mechanisms abound in tough space

July 26, 2021
By Randy Osborne
As amyotrophic lateral sclerosis continues to make headlines, candidates bearing varied approaches proliferate and the indication likely allows for multiple players, given the prospect of a combo regimen.
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Amylyx elixir, neuron-death fixer: $135M series C backs combo drug

July 20, 2021
By Randy Osborne
Amylyx Pharmaceuticals Inc.’s oversubscribed, $135 million series C financing led by Viking Global Investors will help lay the groundwork for commercializing in Canada and Europe, as well as for a second phase III study in the U.S. with lead candidate AMX-0035 for amyotrophic lateral sclerosis.
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Lilly taps Verge Genomics AI-driven discovery platform in new multiyear deal

July 8, 2021
By Michael Fitzhugh
In search of new therapies for amyotrophic lateral sclerosis (ALS), Eli Lilly and Co. has agreed to pay Verge Genomics $25 million in up-front, equity and potential near-term payments, plus as much as $694 million in milestones, to discover and validate up to four new targets for treating the disease over the course of a three-year collaboration. Verge retained rights to its internal lead ALS program, poised to enter the clinic next year.
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Health professional pointing stethoscope at Clinical Trial words, icons

Safety signal halts work on AB Science’s masitinib

June 1, 2021
By Richard Staines
Trading in shares in AB Science SA was suspended Tuesday after a safety signal prompted a voluntary hold on two late-stage clinical studies of its masitinib, in mastocytosis and amyotrophic lateral sclerosis, respectively.
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Walking with assistance

Orphazyme’s arimoclomol fails a phase III in ALS

May 7, 2021
By Lee Landenberger
Despite two recent clinical trial failures, Orphazyme A/S’s arimoclomol is still on track for its June 17 PDUFA date in treating Niemann-Pick disease type C. The newest stumble is in the pivotal study of arimoclomol for treating amyotrophic lateral sclerosis (ALS) as it failed to hit its primary and secondary endpoints.
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Coronavirus, lungs

Implicit’s anti-CD14 MAb heads to the U.S. in NIH COVID-19 phase II trial

April 20, 2021
By Tamra Sami
PERTH, Australia – Implicit Bioscience Ltd.’s lead candidate, IC-14, is the first anti-CD14 monoclonal antibody (MAb) to progress to the clinic as it enters a phase II trial in the U.S. in COVID-19 patients. 
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Person in wheelchair

Orphazyme’s arimoclomol misses endpoints in a phase II/III

March 29, 2021
By Lee Landenberger
Top-line from Orphazyme A/S’ phase II/III trial of arimoclomol for treating inclusion body myositis, a muscle-wasting disease, failed to hit its primary and secondary endpoints. The data caused investors to pull back sharply as shares of Copenhagen-based Orphazyme (NASDAQ:ORPH) had dropped 28.97% on March 29 to close at $8.80 per share.
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Brainstorm to brainstorm on BLA filing in ALS

Feb. 22, 2021
By Lee Landenberger
Brainstorm Cell Therapeutics Inc. said FDA senior leadership told the company the level of clinical data in the Nurown (neurotrophic factor-producing mesenchymal stem cells) phase III trial in amyotrophic lateral sclerosis (ALS) does not provide the threshold of substantial evidence needed to support a BLA.
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Brainstorm's Nurown falls short in phase III ALS trial

Nov. 17, 2020
By Michael Fitzhugh
Shares of Brainstorm Cell Therapeutics Inc. (NASDAQ:BCLI) fell 66.3% to $4.02 on Nov. 17 following news that its autologous cell therapy candidate, Nurown, missed the primary efficacy endpoint of a phase III amyotrophic lateral sclerosis (ALS) study.
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Brain and DNA

Study links two ALS mechanisms

Nov. 2, 2020
By John Fox
Mutations in the annexin A11 gene contribute to motor neuron degeneration in amyotrophic lateral sclerosis by disrupting cellular calcium ion homeostasis and stress granule protein disassembly contributing to ALS neurodegeneration.
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