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Home » amyotrophic lateral sclerosis

Articles Tagged with ''amyotrophic lateral sclerosis''

Macrophage illustration

Targeting periphery could be viable approach in ALS

Oct. 23, 2020
By Nuala Moran
French researchers have shown that modifying peripheral macrophages could quell microglial activation in the central nervous system, slowing the rate of decline and extending survival in mouse models of amyotrophic lateral sclerosis.
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Gene editing illustration

Starting with Biogen deal in ALS, Scribe planning a new chapter in CRISPR story

Oct. 6, 2020
By Cormac Sheridan
Scribe Therapeutics Inc., another CRISPR-based genome editing firm out of the Jennifer Doudna stable, launched with $20 million in series A funding and a deal with Biogen Inc. in amyotrophic lateral sclerosis (ALS), which brings in another $15 million up front and up to $400 million in development and commercial milestones.
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Isaac Veinbergs, CEO, Libra Therapeutics
Newco news

Libra launches with a $29M series A to treat neurodegenerative diseases

Sep. 23, 2020
By Lee Landenberger
In the past 10 years, the advances in understanding the etiology of neurodegenerative diseases have been dramatic. “The development of novel biomarkers and other tools as well are key in aiding diagnostic potential and the ability to track disease progression have been phenomenal,” Isaac Veinbergs, CEO of newly created Libra Therapeutics Inc., told BioWorld.
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Newco news

Tranquis emerges from stealth mode with $30M series A

July 10, 2020
By Mike Ward
Armed with intellectual property generated in the lab of Edgar Engleman at Stanford University, Tranquis Therapeutics Inc. has emerged from stealth mode through a $30 million series A round.
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Hand holding gear, dollar sign

Quralis to take on neurologic diseases with $42M series A

May 13, 2020
By Lee Landenberger
Though Quralis Corp., of Cambridge, Mass., has been developing its pipeline for more than three years, the company now has a $42 million series A in hand to continue researching and developing therapies for amyotrophic lateral sclerosis and frontotemporal dementia.
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Clene Nanomedicine’s phase II for ALS muscles ahead

Jan. 21, 2020
By Lee Landenberger
What’s new inevitably includes an element of the old. Clene Nanomedicine Inc., which just completed enrollment and dosed the first patient in its phase II trial in amyotrophic lateral sclerosis (ALS), literally contains an element of the old in its lead nanocatalytic therapy: gold.
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Brain

Breaching all three meninges improves drug delivery to brain

Dec. 27, 2019
By Anette Breindl
A single injection of SOD1-targeting RNA into the subpial space, which is below the innermost meningeal layer, was able to spread throughout the spinal cord and, via retrograde delivery, into brain centers that project to the spinal cord in several animal models, including primates.
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Brain
Spot on

Breaching all three meninges improves drug delivery to brain

Dec. 24, 2019
By Anette Breindl
A single injection of SOD1-targeting RNA into the subpial space, which is below the innermost meningeal layer, was able to spread throughout the spinal cord and, via retrograde delivery, into brain centers that project to the spinal cord in several animal models, including primates.
Read More

Neurology ‘adapting’ to oncology model with new trial design

Nov. 4, 2019
By Marie Powers
The oncology field pioneered adaptive trial designs through efforts such as I-SPY 2 (Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging And moLecular Analysis 2), Puma Biotechnology Inc.’s phase II study of the pan-HER tyrosine kinase inhibitor neratinib (Nerlynx) as neoadjuvant therapy in metastatic breast cancer, and the ongoing multidrug, biomarker-driven non-small-cell lung cancer trial known as Lung-MAP.
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