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Home » brain

Articles Tagged with ''brain''

Silhouette of head and brain with DNA double helixes
Neurology/psychiatric

Armamentarium, the new genetic weapon to study brain disorders

May 22, 2025
By Mar de Miguel
No Comments
A collaboration of scientists from the NIH Brain Initiative consortium has published eight simultaneous studies in Neuron, Cell, Cell Genomics, Cell Reports and Cell Reports Methods, with the results of the Armamentarium project, a new set of gene therapy tools for the research and treatment of human brain disorders. The methodology, based on genetic techniques, RNA detection, genomic enhancers and viral vectors, is designed to access different CNS cell types, neuronal and non-neuronal cells, with common and reproducible protocols now available for any laboratory.
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Illustration of a pink head and blue head
Neurology/psychiatric

The brain ages and survives differently in females and males

Jan. 29, 2025
By Mar de Miguel
The way the brain ages is not the same in women and men. A study in mice has observed differences in the expression of the maternal and paternal X chromosomes that could explain variation in brain aging between the sexes and a faster deterioration in some women. Another study has discovered different survival strategies in the microglial cells of females and males. Both studies highlight sex differences that could have implications for several age-related neurological disorders, such as Alzheimer’s or Parkinson’s.
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Video still showing the brain inside an adult fruit fly

The map for a journey to the center of the brain

Dec. 27, 2024
By Mar de Miguel
In the 1970s, scientists from several countries proposed to reconstruct, one by one, all the neurons in the brain as they appear under an electron microscope. They started with a small worm. Caenorhabditis elegans has only 302 neurons. It took 16 years. How much time would be required to repeat this arduous task for the 100 billion neurons in the human brain?
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Video still showing the brain inside an adult fruit fly

The map for a journey to the center of the brain

Dec. 24, 2024
By Mar de Miguel
In the 1970s, scientists from several countries proposed to reconstruct, one by one, all the neurons in the brain as they appear under an electron microscope. They started with a small worm. Caenorhabditis elegans has only 302 neurons. It took 16 years. How much time would be required to repeat this arduous task for the 100 billion neurons in the human brain?
Read More
Video still showing the brain inside an adult fruit fly
Neurology/psychiatric

The map for a journey to the center of the brain

Dec. 23, 2024
By Mar de Miguel
In the 1970s, scientists from several countries proposed to reconstruct, one by one, all the neurons in the brain as they appear under an electron microscope. They started with a small worm. Caenorhabditis elegans has only 302 neurons. It took 16 years. How much time would be required to repeat this arduous task for the 100 billion neurons in the human brain?
Read More
Changes in brain during pregnancy
Neurology/psychiatric

The human brain remodels gray and white matter during pregnancy

Sep. 17, 2024
By Mar de Miguel
The map of the human brain is not a static image of the cellular architecture of the central nervous system (CNS). Throughout life, all living beings are born, develop and age. The brain of pregnant mothers reflects a dynamic that modifies this general picture. A collaboration of scientists from the University of California has studied the changes in the adult brain during pregnancy and observed that a large part of it adapts during the development of the fetus.
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Brain map visualization of the neurological differences between two people.
Neurology/Psychiatric

Building the map for every cell of the human brain

Oct. 25, 2023
By Mar de Miguel
To understand the human brain, an international consortium of scientists has created the most complete atlas of this organ to date. The map reveals the anatomy, the architecture of the tissues, how or where each cell is, their function, gene expression and regulation. On Oct. 12, 2023, Science and Science Advances published a group of 21 studies that unveiled the map of the human brain, as well as the brains of nonhuman primates and mice, cell by cell, for an adult model and for the different stages of development.
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Liver illustration
Gastrointestinal

EASL 2023: Insights on bidirectional crosstalk in the liver-brain axis

June 23, 2023
By Coia Dulsat
While the liver is mostly known as the core of metabolism, contributing to the storage of nutrients and excretion of toxic substances, there is an increasing interest in how it interacts with the central nervous system through the liver-brain axis. At the 2023 European Association for the Study of the Liver (EASL) meeting in Vienna, Austria, group leader Kristina Schoonjans and her colleague Hadrien Demagny from the Laboratory of Metabolic Signaling at École Polytechnique Fédérale de Lausanne, Switzerland, gave talks setting out the context of inter-organ communication in liver disease, adding new findings from their research in the liver-brain axis.
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Neurology/Psychiatric

Map of brain autophagic vesicles could be a guide for neurodegenerative research

June 16, 2023
By Mar de Miguel
The degradation pathways of cellular components can be shared by different molecules or selectively replace different substances and organelles. In the brain, synaptic transmission involves signaling pathways for a wide range of molecules, vesicles and receptors that require constant recycling. A proteomic study from the University of Lausanne and the University of Fribourg sheds light on brain autophagy-selective routes in adolescent, adult and aged brains.
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Neurology/Psychiatric

Transcriptomic atlas classifies 40 brain diseases

May 3, 2023
By Mar de Miguel
The map of the genetic activity of the risk genes that affect the central nervous system (CNS) reveals the molecular signatures associated with the neurological pathologies in this organ. A study by researchers at McGill University in Canada and the Allen Institute for Brain Science in Washington compared 40 brain diseases with this technology and classified them into five groups whose members shared the same transcriptional pattern.
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