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Home » non-small-cell lung cancer

Articles Tagged with ''non-small-cell lung cancer''

Gold dollar sign

ESMO where that came from: Nuvalent bags $500M on hot early data

Sep. 17, 2024
By Randy Osborne
Scattered investor qualms about Nuvalent Inc.’s largely upbeat data during the European Society for Medical Oncology (ESMO) meeting in Barcelona didn’t stop the firm from pricing an upsized $500 million public offering. The Cambridge, Mass.-based firm is selling 5 million shares of class A common stock at $100 each. The offering is expected to close on Sept. 18, with underwriters holding a 30-day option to purchase up to 750,000 more shares.
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Concept art for targeting cancer
Immuno-oncology

23andme’s 23ME-01473 restores NK- and T-cell antitumoral capacity by activation of NKG2D

Sep. 16, 2024
UL16 binding protein 6 (ULBP6) is a molecule belonging to the stress-induced NKG2D ligand family and its expression is up-regulated on the surface of cancerous cells, binding to the immune-activating NKG2D receptor on natural killer (NK) and T cells, thus promoting immune evasion.
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Cancer

Bristol Myers Squibb discovers PROTACs for NSCLC

Sep. 12, 2024
Bristol Myers Squibb Co. has described proteolysis targeting chimera (PROTAC) compounds comprising a E3 ubiquitin ligase-binding moiety coupled to a proto-oncogene tyrosine-protein kinase receptor Ret (RET; CDHF12; PTC) targeting moiety through a linker reported to be useful for the treatment of non-small-cell lung cancer.
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3D illustration and light micrograph of lung cancer.

Detailed data affirm ivonescimab tops Keytruda in NSCLC trial

Sep. 10, 2024
By Jennifer Boggs
More than three months ago, investors first learned that ivonescimab, a PD-1/VEGF-targeting bispecific antibody from Summit Therapeutics and Akeso Pharmaceuticals Inc., bested Keytruda (pembrolizumab) in PD-L1-positive non-small-cell lung cancer (NSCLC). At the 2024 World Conference on Lung Cancer over the weekend, Summit rolled out detailed data from the phase III Harmoni-2 trial, which included a nearly doubling of progression-free survival for ivonescimab compared to Merck & Co. Inc.’s established blockbuster drug.
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3D illustration and light micrograph of lung cancer.

Detailed data affirm ivonescimab tops Keytruda in NSCLC trial

Sep. 9, 2024
By Jennifer Boggs
More than three months ago, investors first learned that ivonescimab, a PD-1/VEGF-targeting bispecific antibody from Summit Therapeutics and Akeso Pharmaceuticals Inc., bested Keytruda (pembrolizumab) in PD-L1-positive non-small-cell lung cancer (NSCLC). At the 2024 World Conference on Lung Cancer over the weekend, Summit rolled out detailed data from the phase III Harmoni-2 trial, which included a nearly doubling of progression-free survival for ivonescimab compared to Merck & Co. Inc.’s established blockbuster drug.
Read More
Cancer cells
Immuno-oncology

Nextpoint unveils T-cell engager for B7-H7-positive solid tumors

Sep. 6, 2024
Nextpoint Therapeutics Inc. has unveiled NPX-372, a novel T-cell engager for solid tumors. NPX-372 is a CD3 bispecific antibody with unique capabilities to redirect T cell-mediated cytotoxicity toward B7-H7-positive tumors such as colorectal carcinoma, non-small-cell lung cancer, renal cell carcinoma and prostate cancer.
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Jacobio chairman, CEO Yinxiang Wang (right) and Allist chairman and general manager Jinhao Du at a signing ceremony Aug. 30

Jacobio, Allist shake on ¥900M China deal for lung cancer combo

Sep. 3, 2024
By Marian (YoonJee) Chu
Jacobio Pharmaceuticals Group Co. Ltd. out-licensed rights for two lung cancer assets in China to Shanghai Allist Pharmaceuticals Co. Ltd. through a potential ¥900 million (US$126.4 million) deal. Beijing-headquartered Jacobio said Aug. 30 that it signed off development, regulatory and commercial milestone rights to both glecirasib, a KRAS G12C inhibitor first targeting non-small-cell lung cancer, and a SHP2 inhibitor called JAB-3312.
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Lung cancer illustration
Cancer

Novel EGFR inhibitor overcomes common resistances to NSCLC treatments

Sep. 3, 2024
Researchers from Nankai University reported on [I], a novel EGFR L858R/T790M/C797S inhibitor designed to overcome the most frequent resistances to non-small-cell lung cancer (NSCLC) treatment.
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HKEX exterior

TYK Medicines raises $74M in HKEX IPO to launch EGFR inhibitor

Aug. 27, 2024
By Tamra Sami
TYK Medicines Inc. made a strong debut on the main board of the Hong Kong Stock Exchange (HKSE), raising HK$579 million (US$74.32 million) to commercialize its lead compound, EGFR inhibitor TY-9591, now in pivotal trials in patients with EGFR mutation-positive lung cancer.
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Antibody-drug conjugate

Adcendo licenses Multitude’s phase I-ready ADC for $1B+

Aug. 27, 2024
By Tamra Sami
Adcendo ApS has inked a deal with Multitude Therapeutics Inc. and is licensing Multitude’s phase I-ready antibody-drug conjugate (ADC), ADCE-T02, which targets tissue factor. Under the deal, Copenhagen, Denmark-based Adcendo gains exclusive development and commercialization rights for the ADC globally, excluding greater China (mainland China, Hong Kong, Macao and Taiwan) where Multitude retains all rights.
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