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Home » non-small-cell lung cancer

Articles Tagged with ''non-small-cell lung cancer''

3D illustration and light micrograph of lung cancer.
Cancer

Mitocarex validates potential role of target SLC25 carrier protein in NSCLC

July 23, 2024
Scisparc Ltd.’s Mitocarex Bio Ltd. venture has validated the potential significant involvement of its target SLC25 carrier protein, using non-small-cell lung cancer (NSCLC) cells with diverse genetic backgrounds. Mitocarex used genetic manipulations and 3D spheroid systems, mimicking the main features of human solid tumors, to demonstrate the discovery.
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3D illustration demonstrating antibody-drug conjugate.
Immuno-oncology

Zymeworks obtains IND clearance for FRα-targeted ADC

July 22, 2024
Zymeworks Inc. has received IND clearance from the FDA for ZW-191, the company’s novel folate receptor-α (FRα)-targeted topoisomerase I (TOPO1) inhibitor antibody-drug conjugate (ADC). Clinical development is set to begin this year, with filings to initiate studies outside the U.S. to be made in the second half of this year.
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Lyell sinks on phase I death, despite ROR1 CAR T efficacy

June 26, 2024
By Karen Carey
A patient death and cases of pneumonitis overshadowed positive signs of efficacy for South San Francisco-based Lyell Immunopharma Inc.’s ROR1 CAR T-cell candidate, LYL-797, which is treating triple-negative breast cancer and non-small-cell lung cancer in a phase I trial.
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T cells attacking cancer cells
Immuno-oncology

CDR-Life unveils new T-cell engagers

June 26, 2024
CDR-Life Inc. has expanded its pipeline of novel T-cell engagers (TCE) with the addition of CDR-813 and CDR-505. CDR-813 is a highly potent and selective TCE candidate targeting tumors expressing PRAME (preferentially expressed antigen in melanoma) in HLA-A*02:01 patients.
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Non-Hodgkin lymphoma cells in the blood flow

China’s NMPA clears Dizal’s golidocitinib in T-cell lymphoma

June 25, 2024
By Tamra Sami
China’s National Medical Products Administration (NMPA) approved Dizal Pharmaceutical Co. Ltd.’s golidocitinib for treating adults with relapsed or refractory peripheral T-cell lymphoma whose disease has progressed or was refractory to at least one prior systemic therapy.
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Non-Hodgkin lymphoma cells in the blood flow

China’s NMPA clears Dizal’s golidocitinib in T-cell lymphoma

June 20, 2024
By Tamra Sami
China’s National Medical Products Administration (NMPA) approved Dizal Pharmaceutical Co. Ltd.’s golidocitinib for treating adults with relapsed or refractory peripheral T-cell lymphoma whose disease has progressed or was refractory to at least one prior systemic therapy.
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Microscope with laptop displaying histology image.
Cancer

Genfleet’s KRAS G12D inhibitor GFH-375 receives NMPA clearance to enter clinic in China

June 20, 2024
Genfleet Therapeutics (Shanghai) Co. Ltd. has obtained clearance from China’s National Medical Products Administration (NMPA) to advance GFH-375 (VS-7375) into a phase I/II study in patients with advanced solid tumors with KRAS G12D mutation.
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Photomicrograph of fine needle aspiration cytology of a pulmonary nodule showing adenocarcinoma, a type of non-small-cell carcinoma.
Immuno-oncology

Triple nanotherapy could benefit more lung cancer patients

June 20, 2024
By Mar de Miguel
A new approach against non-small-cell lung cancer (NSCLC) has combined immunotherapy with molecularly targeted therapy to activate the immune response and inhibit oncogenic pathways, which prevented tumor progression and eliminated cancer cells. Brigham and Women’s Hospital scientists have developed nanoparticles loaded with antibody conjugates that could deliver large amounts of treatment to the tumor tissue. This new strategy could improve the results of conventional immunotherapy in these patients and reduce toxicity of existing treatments.
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Celltrion seeks US IND nod for Keytruda biosimilar phase III

June 18, 2024
By Marian (YoonJee) Chu
As competition rises in the Keytruda (pembrolizumab) biosimilar space, Celltrion Inc. is the latest to announce that it filed an IND application to the U.S. FDA to start a global phase III trial for its own Keytruda biosimilar, dubbed CT-P51. Incheon, South Korea-based Celltrion, which previously said it would differentiate from the pack by developing an easier-to-administer subcutaneous biosimilar of pembrolizumab, announced June 17 plans to start a global comparative phase III study of CT-P51 and Keytruda.
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Celltrion seeks US IND nod for Keytruda biosimilar phase III

June 17, 2024
By Marian (YoonJee) Chu
As competition rises in the Keytruda (pembrolizumab) biosimilar space, Celltrion Inc. is the latest to announce that it filed an IND application to the U.S. FDA to start a global phase III trial for its own Keytruda biosimilar, dubbed CT-P51. Incheon, South Korea-based Celltrion, which previously said it would differentiate from the pack by developing an easier-to-administer subcutaneous biosimilar of pembrolizumab, announced June 17 plans to start a global comparative phase III study of CT-P51 and Keytruda.
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