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Home » type 2 diabetes

Articles Tagged with ''type 2 diabetes''

Xpressgt kit

Directsens partners with Metage to validate test for early type 2 diabetes

July 21, 2025
By Shani Alexander
Directsens GmbH recently signed a collaboration agreement with Metage, an Austrian research consortium, to advance a test for the early detection of type 2 diabetes. The focus of the partnership will be on validating Directsens’ Xpressgt assay, which measures 2-hydroxybutyrate levels in venous blood, and could be used by clinicians to inform patients they are at risk of developing type 2 diabetes.
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Endocrine/metabolic

Improved muscle health and glucose metabolism shown with JUV-161

July 15, 2025
No Comments
Obesity and diabetes are known risk factors for sarcopenia. Insulin resistance that occurs during type 2 diabetes promotes impaired synthesis of muscle protein and muscle breakdown. Juvena Therapeutics Inc. has presented data at ENDO 2025 conference for JUV-161, a novel secreted protein that induces insulin sensitization, regarding its impact on blood glucose and muscle in mice with type 2 diabetes (db/db mice).
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Illustration of the β2-adrenergic receptor
Endocrine/metabolic

Exercise-mimicking compound offers alternative to GLP-1 therapies

June 27, 2025
By Mar de Miguel
No Comments
An experimental drug for treating diabetes and obesity has been shown to lower blood sugar levels and increase fat burning. It is a β2-adrenergic receptor (β2AR) agonist that mimics the effects of physical exercise by activating skeletal muscle metabolism. Unlike GLP-1-based treatments such as semaglutide and tirzepatide, this new compound, developed by researchers at the Karolinska Institute, Stockholm University, and the biotech company Atrogi AB, does not suppress appetite or cause muscle loss. 
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Blood glucose chart and monitor, stethoscope, injector pen
ADA 2025

Two new options presented at ADA for early diagnosis of T1D

June 24, 2025
By Annette Boyle
Classically, the diagnosis of type 1 diabetes comes after a patient presents with unexplained weight loss, extreme thirst and frequent urination and a lab test reveals off-the-charts blood glucose levels. At the 85th Scientific Sessions of the American Diabetes Association in Chicago, researchers highlighted two options – a blood test and a machine learning model – for diagnosing the disease much earlier in its progression, when damage to the pancreas' beta cells could be slowed.
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Ozempic pen and packaging

EMA warns Ozempic linked to ‘very rare’ side effect

June 6, 2025
By Nuala Moran
No Comments
The EMA’s safety committee has issued a warning that the GLP-1 receptor agonist Ozempic (semaglutide, Novo Nordisk A/S) can cause an acute eye condition in which the optic nerve is damaged by a sudden loss of blood supply. After reviewing several large epidemiological studies, clinical trial and in-market data, EMA’s Pharmacovigilance Risk Assessment Committee has concluded non-anterior ischemic optic neuropathy is a “very rare” side effect of Ozempic, that “may affect up to one in 10,000 people taking semaglutide.
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GLP-1 receptor, inactive form vs. active complex with an agonist (semaglutide) and G-proteins

Fractyl, Bariendo developing off-ramp for post-GLP-1 maintenance

June 4, 2025
By Annette Boyle
Far from eliminating the need for weight-loss procedures, glucagon-like peptide-1 receptor agonists could drive more people to seek them out. At least that’s what Fractyl Health Inc. and Bariendo Inc. hope, and they have strong evidence to support their case with a recent meta-analysis showing that individuals discontinuing the popular weight loss medications regain all their weight and more within two years.
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Kakao Pasta app

Kakao Healthcare brings CGM app to Japan

May 16, 2025
By Marian (YoonJee) Chu
Step aside, Marco Polo: Kakao Healthcare Corp. plans to bring PASTA to Japan. PASTA is Kakao's AI-based continuous glucose monitoring (CGM) management mobile application, which will be available in Japan through a new subsidiary as the health care company works to expand its global presence.  
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Freestyle Libre 3 sensor with smartphone app

Abbott studies show CGM users have fewer hospitalizations

May 15, 2025
By Annette Boyle
A pair of studies published in Diabetologia demonstrate that use of continuous glucose monitors (CGMs) reduces hospitalizations in people with type 1 diabetes and in those with type 2 diabetes who use insulin compared to use of capillary blood glucose monitoring. Abbott Laboratories’s REFLECT real-world studies showed that use of its Freestyle Libre CGMs reduced the severity of cardiovascular conditions associated with diabetes and, consequently, led to fewer in-patient stays.
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Pills, bottle, scale and-measuring tape

Septerna joins a $2.2B obesity deal with Novo

May 14, 2025
By Lee Landenberger
No Comments
In a deal that could top out at about $2.2 billion, Septerna Inc. is getting $200 million up front from Novo Nordisk A/S in a collaboration to develop oral treatments for obesity, type 2 diabetes and other cardiometabolic indications. There will be four programs for discovering, developing and commercializing small molecules targeting G protein-coupled receptors, which includes GLP-1, GIP and glucagon receptors, with both companies putting their shoulders to conducting research from discovery to choice of candidate.
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Endocrine/metabolic

Stimulating glucose uptake by GLUT4 to treat type 2 diabetes

May 14, 2025
No Comments
Researchers at Daiichi Sankyo Co. Ltd. have developed a xanthene compound that can promote glucose uptake by GLUT4 into skeletal muscle.
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