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Home » Huntington’s disease

Articles Tagged with ''Huntington’s disease''

Stock chart with falling red arrow

Uniqure stock drops 40% as Huntington’s disease data fail to convince

June 21, 2023
By Cormac Sheridan
Shares in Uniqure NV fell sharply on inconclusive interim data from a U.S. phase I/II trial of its gene therapy for Huntington’s disease. The stock (NASDAQ:QURE) hit a six-year low during trading on June 21, ending the day at $11.62, down 40%.
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Dorsal striatum and its neurons in Huntington's disease
Neurology/Psychiatric

SLS-009, an allele-specific gene therapy, reduces mHTT aggregates in Huntington’s disease mice

June 6, 2023
Researchers from Seelos Therapeutics Inc. presented the discovery and preclinical evaluation of a gene therapy candidate, SLS-009, for the treatment of Huntington’s disease (HD).
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PET imaging of RELN-COLBOS (H3447R) carrier brain showing limited aggregation of tau
Neurology/Psychiatric

Brain gene and cell strategies could ‘open the safe’ in neurodegenerative disorders

May 23, 2023
By Mar de Miguel
One of the challenges in designing genetic and cellular strategies is getting the therapy to the right place. This is even more complicated when it comes to the nervous system. The brain is a complex organ that contains the most differentiated and inaccessible cells in human biology. It is an impassable safe, protected by the blood-brain barrier.
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Illustration comparing healthy vs. Huntington's disease neuron and brain
Neurology/Psychiatric

Rumi Scientific presents in vivo data on BRD9 inhibition in Huntington’s disease model

April 27, 2023
Rumi Scientific Inc. has presented data demonstrating in vivo proof of concept of a disease-modifying effect of bromodomain...
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Dorsal striatum and its neurons in Huntington's disease
Neurology/Psychiatric

Life Edit Therapeutics presents preclinical data on Huntington’s disease program

April 26, 2023
Life Edit Therapeutics Inc., an Elevatebio LLC company, has presented the first preclinical data from the its Huntington’s disease program.
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Speech Vitals-ALS mobile app

FDA grants Aural Analytics breakthrough device designation

March 29, 2023
By Annette Boyle
Aural Analytics Inc. received a breakthrough device designation from the U.S. FDA for its Speech Vitals-ALS technology, a software application that collects and analyzes speech recordings to help monitor amyotrophic lateral sclerosis (ALS) in adults in clinic and home settings. The software could improve management of the devastating disease.
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White Euro symbol on blue background
Newco news

Teitur Trophics targeting neurodegenerative disease with €28M series A round

March 14, 2023
By Nuala Moran
Newco Teitur Trophics ApS has raised €28 million (US$30.1 million) in a series A with which it will lay out a new route to targeting sortilin in the treatment of neurodegenerative diseases. The company is targeting the sortilin-related Vps10p domain containing receptor, which plays a role in regulating a number of pathways involved in the control of neuronal viability and function.
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Neurology/Psychiatric

Series A financing at Teitur Trophics to fund neurodegenerative disease pipeline

March 14, 2023
Teitur Trophics ApS, a spinout from Aarhus University seeded by the Bioinnovation Institute in 2020, has completed a €28 million (US$30.1 million) series A financing. Teitur has developed a platform of first-in-class cyclic peptides with a novel mechanism that preserves neuronal function, and these peptides have the potential to treat a broad range of neurodegenerative diseases.
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Neurology/Psychiatric

PTC Therapeutics divulges new compounds to treat Huntington's disease

Feb. 22, 2023
PTC Therapeutics Inc. has synthesized heteroaryl compounds acting as huntingtin (HTT) (mutant) expression inhibitors reported to be useful for the treatment of Huntington's disease.
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GBS navigation system directs Annexon toward pivotal study; effort in HD on track, too

Jan. 19, 2023
By Randy Osborne
Upcoming catalysts from Annexon Biosciences Inc. put some joy into shares as the firm talked up its prospects during the recent J.P. Morgan Healthcare Conference, where attendees heard Jan. 8 about the news ahead with C1q protein complex inhibitor ANX-005 in Huntington’s disease (HD) as well as progress in Guillain-Barre syndrome (GBS), and more. The stock (NASDAQ:ANNX) enjoyed a 43% stock boost in the days after JPM, rising from $4.79 on Jan 8 to $6.84 on Jan. 13.
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