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Home » Alzheimer’s disease

Articles Tagged with ''Alzheimer’s disease''

Elderly woman holding illustration of brain with missing puzzle piece
Neurology/psychiatric

Marvel Biotechnology’s MB-204 as therapeutic agent for Alzheimer’s disease

Aug. 11, 2025
No Comments
Phosphorylation of the protein Tau is a key post-translational feature in tauopathies like Alzheimer’s disease (AD), which leads to microtubule dysfunction and Tau accumulation. Recent findings have suggested the blockade of the adenosine A2A receptor as an approach that improves the outcome in amyloid and Tau models.
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Illustration of magnifying glass inspecting brain
Neurology/psychiatric

Subtyping beats a path toward precision medicine in Alzheimer’s

Aug. 7, 2025
By Anette Breindl
No Comments
Subtyping is what made precision medicine in cancer a reality. And for successful drug discovery in all its stages, finding subtypes in Alzheimer’s disease is all but imperative.
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Results of lithium orotate vs. lithium carbonate on amyloid-β and tau
Neurology/psychiatric

Lithium could change Alzheimer's care, but not all forms work

Aug. 7, 2025
By Mar de Miguel
No Comments
The difference between the origin of Alzheimer's disease (AD) and its symptoms is an obstacle to finding effective treatments. Scientists focused on amyloid-β (Aβ) plaques and tau aggregates to slow neurodegeneration and cognitive decline. Without identifying what causes AD, approved treatments do not provide much benefit. However, new findings suggest that restoring lithium levels in the brain could prevent and treat AD. Not just any lithium would work, just the forms that do not bind to Aβ.
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Tau protein in Alzheimer's disease
Neurology/psychiatric

Merck’s MK-2214 shows potential to slow Alzheimer’s pathology

Aug. 6, 2025
No Comments
Abnormal tau aggregation is a hallmark of Alzheimer’s disease (AD) and a major contributor to neurodegeneration, synaptic dysfunction, and progressive functional decline. Antibodies against extracellular tau represent a potential therapeutic approach aimed at reducing pathological spread and delaying the clinical progression of AD. Researchers from Merck & Co., Inc. presented the preclinical development of MK-2214, a murine IgG2a monoclonal antibody that selectively targets the pathological phospho-epitope pSer413 of the tau protein.
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Neurology/psychiatric

ONC-841 reduces SIGLEC10-mediated Aβ plaque formation

Aug. 6, 2025
No Comments
Sialic acid-binding immunoglobulin-like lectin 10 (SIGLEC10) is a microglia-specific surface receptor in the central nervous system, whose expression has been increasingly implicated in regulating microglial responses and identified as a genetic driver of amyloid plaque formation during Alzheimer’s disease (AD) progression.
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Illustration of magnifying glass inspecting brain

Subtyping beats a path toward precision medicine in Alzheimer’s

Aug. 5, 2025
By Anette Breindl
No Comments
Subtyping is what made precision medicine in cancer a reality. And for successful drug discovery in all its stages, finding subtypes in Alzheimer’s disease is all but imperative. Prior to the approval of the modestly effective Leqembi (lecanemab, Biogen Inc./Eisai Co. Ltd.), Kisunla (donanemab, Eli Lilly and Co.), and the since-withdrawn Aduhelm (aducanumab, Biogen Inc./Eisai Co. Ltd.), more than a dozen failed phase III clinical trials were all that amyloid-targeting drugs had to show for themselves for decades of effort.
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3D-rendered illustration of a synapse cross-section
Neurology/psychiatric

PAK1 inhibition confers synaptic spine resilience in Alzheimer‘s models

Aug. 5, 2025
No Comments
In Alzheimer’s disease (AD), degeneration of synapses, including synaptic spines, has been linked to cognitive losses.
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Illustration of magnifying glass inspecting brain
Neurology/psychiatric

Subtyping beats a path toward precision medicine in Alzheimer’s

Aug. 5, 2025
By Anette Breindl
No Comments
Subtyping is what made precision medicine in cancer a reality. And for successful drug discovery in all its stages, finding subtypes in Alzheimer’s disease is all but imperative. Prior to the approval of the modestly effective Lequembi (lecanemab, Biogen Inc./Eisai Co. Ltd.) Kisunla (donanemab, Eli Lilly and Co.), and the since-withdrawn Aduhelm (aducanumab, Biogen Inc./Eisai Co. Ltd.), more than a dozen failed phase III clinical trials were all that amyloid-targeting drugs had to show for themselves for decades of effort.
Read More
Illustration of microglia
Neurology/psychiatric

Enrupatinib mitigates AD pathology in mouse models

Aug. 4, 2025
No Comments
Neuroinflammation is a hallmark of Alzheimer’s disease (AD), driven in part by chronic microglial activation and elevated pro-inflammatory cytokines, which contribute to neuronal damage and cognitive decline. Targeting microglial activity has emerged as a promising therapeutic approach.
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Heart, artery with cholesterol, brain
AAIC 2025

In Broadway trial, a hopeful tune for Alzheimer’s prevention

July 31, 2025
By Anette Breindl
No Comments
At the 2025 Alzheimer’s Association International Conference (AAIC), one of the bigger splashes was made by a cardiovascular drug.
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