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Home » Alzheimer’s disease

Articles Tagged with ''Alzheimer’s disease''

Man piecing together a puzzle
Neurology/psychiatric

VU-0810464 improves synaptic plasticity and memory impairment in Alzheimer’s disease

July 14, 2025
No Comments
A team of researchers from the University of Castilla-La Mancha, Spain, further investigated the link between hippocampal G protein-activated inward rectifier potassium channel (GIRK) and Alzheimer’s disease pathology.
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Scientific figure illustrating astrocytes and neuron synapse
Neurology/psychiatric

Glia 2025: Microglial crosstalk could be early Alzheimer’s targeting opportunity

July 14, 2025
By Anette Breindl
No Comments
“Loss of synapses and dysfunctional synapses in a region-specific way is important in Alzheimer’s. It’s actually the strongest correlate of cognitive decline, far more so than plaques and tangles, which are the pathological hallmarks,” Soyon Hong told the audience at the XVII Meeting on Glial Cells in Health and Disease, which was held in Marseille last week.
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Elderly hands holding broken brain structure

Xpro phase II miss as Inmune’s Mindful tunes in to AD subgroup

June 30, 2025
By Randy Osborne
No Comments
Inmune Bio Inc. claimed a phase II win with TNF inhibitor Xpro (pegipanermin) in early Alzheimer’s disease (AD), though the study missed its primary and secondary endpoints, leading shares of the firm (NASDAQ:INMB) to close at $2.16, down $3.18, or almost 60%.
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Brain, syringe hovering over hands

NICE rejects Lilly‘s Kisunla and Eisai‘s Leqembi

June 20, 2025
By Nuala Moran
No Comments
To no great surprise, the U.K.’s health technology assessment body has found that the benefits of the first two approved Alzheimer’s disease drugs are too small to justify the costs. Neither Kisunla (donanemab, Eli Lilly and Co. Inc.) or Leqembi (lecanemab, Eisai Co. Ltd.), “demonstrate sufficient benefit to justify their high cost, including the cost of administering them,” the National Institute of Health and Care Excellence (NICE) concluded after an extended appraisal of the two amyloid neutralizing antibodies.
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Amyloid beta peptides on neurons
Neurology/psychiatric

TMEM119 clears amyloid beta deposits in AD mice

June 17, 2025
No Comments
Alzheimer’s disease (AD) progression involves microglial activation, and restoring or maintaining microglia homeostasis is a therapeutic approach to fight against AD.
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Aribio-Arcera signing

Aribio fortifies Arcera alliance with $600M AR-1001 supply deal

June 10, 2025
By Marian (YoonJee) Chu
No Comments
Aribio Co. Ltd. signed a $600 million license deal with Acino International AG, an Arcera Life Sciences subsidiary, granting the latter commercial rights to its oral Alzheimer’s disease therapy, AR-1001, in select countries including the Middle East.
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Elderly woman holding illustration of brain with missing puzzle piece
Neurology/psychiatric

Grant supports Mindimmune’s development of MITI-101 for Alzheimer’s disease

June 6, 2025
No Comments
Mindimmune Therapeutics Inc. has been awarded a grant by Rhode Island Life Science Hub to accelerate preclinical development work on MITI-101 for the treatment of mild to moderate Alzheimer’s disease. The award will accelerate development work needed to start first-in-human studies.
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Biomarkers

Stress sensor inhibition ameliorates Alzheimer's pathology in mice

June 4, 2025
No Comments
Astrocytes are crucial for brain homeostasis and synaptic activity under healthy conditions, and are activated during neuroinflammation, neural damage and neurodegeneration, such as in Alzheimer's disease (AD).
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Brain and DNA
Neurology/psychiatric

Caveolin-1 gene therapy preserves cognitive function in Alzheimer’s disease models

June 3, 2025
No Comments
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by synaptic dysfunction, neuronal loss and the accumulation of amyloid plaques and neurofibrillary tangles, ultimately leading to cognitive decline. Despite significant research efforts, no existing treatment has proven effective enough to stop or reverse the progression of the disease.
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Prothena sinks on phase III miss in amyloidosis

May 27, 2025
By Nuala Moran
No Comments
History has repeated itself for Prothena Corp. plc, which has reported a second phase III miss for birtamimab in the treatment of light chain amyloidosis. Announcing the trial failure, the Dublin-based company said it is planning “a substantial reduction” of its organization.
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