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Home » Alzheimer’s disease

Articles Tagged with ''Alzheimer’s disease''

Amyloid beta peptides on neurons
Neurology/psychiatric

TMEM119 clears amyloid beta deposits in AD mice

June 17, 2025
No Comments
Alzheimer’s disease (AD) progression involves microglial activation, and restoring or maintaining microglia homeostasis is a therapeutic approach to fight against AD.
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Aribio-Arcera signing

Aribio fortifies Arcera alliance with $600M AR-1001 supply deal

June 10, 2025
By Marian (YoonJee) Chu
No Comments
Aribio Co. Ltd. signed a $600 million license deal with Acino International AG, an Arcera Life Sciences subsidiary, granting the latter commercial rights to its oral Alzheimer’s disease therapy, AR-1001, in select countries including the Middle East.
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Elderly woman holding illustration of brain with missing puzzle piece
Neurology/psychiatric

Grant supports Mindimmune’s development of MITI-101 for Alzheimer’s disease

June 6, 2025
No Comments
Mindimmune Therapeutics Inc. has been awarded a grant by Rhode Island Life Science Hub to accelerate preclinical development work on MITI-101 for the treatment of mild to moderate Alzheimer’s disease. The award will accelerate development work needed to start first-in-human studies.
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Biomarkers

Stress sensor inhibition ameliorates Alzheimer's pathology in mice

June 4, 2025
No Comments
Astrocytes are crucial for brain homeostasis and synaptic activity under healthy conditions, and are activated during neuroinflammation, neural damage and neurodegeneration, such as in Alzheimer's disease (AD).
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Brain and DNA
Neurology/psychiatric

Caveolin-1 gene therapy preserves cognitive function in Alzheimer’s disease models

June 3, 2025
No Comments
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by synaptic dysfunction, neuronal loss and the accumulation of amyloid plaques and neurofibrillary tangles, ultimately leading to cognitive decline. Despite significant research efforts, no existing treatment has proven effective enough to stop or reverse the progression of the disease.
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Prothena sinks on phase III miss in amyloidosis

May 27, 2025
By Nuala Moran
No Comments
History has repeated itself for Prothena Corp. plc, which has reported a second phase III miss for birtamimab in the treatment of light chain amyloidosis. Announcing the trial failure, the Dublin-based company said it is planning “a substantial reduction” of its organization.
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Brain and neural networks
Neurology/psychiatric

A novel coumarin-based radiolabel for monoamine oxidase B in neurodegenerative disease

May 27, 2025
No Comments
Researchers at North China Electric Power University and collaborators have developed novel radiolabels for the membrane-bound monoamine oxidase-B that feature a coumarin core.
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Neurology/psychiatric

Aquinnah Pharmaceuticals describes new MAPT aggregation inhibitors

May 26, 2025
Aquinnah Pharmaceuticals Inc. has identified microtubule-associated protein tau (PHF-tau; MAPT) aggregation inhibitors reported to be useful for the treatment of Alzheimer's disease and frontotemporal dementia.
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Illustration of amyloid plaques in Alzheimer's disease
Neurology/psychiatric

Clusterin enhancer exerts neuroprotection in vivo

May 26, 2025
No Comments
The third most significant genetic risk factor for late-onset Alzheimer’s disease is a mutation in the clusterin (CLU) gene that disrupts the expression of sCLU, a cytoprotective protein involved in preventing protein aggregation and promoting the clearance of misfolded proteins.
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Brain with handshake and cityscape

Vigil takeover brings TREM2 Alzheimer’s prospect to Sanofi

May 22, 2025
By Randy Osborne
No Comments
Sanofi SA made good on its plan to bear down on M&A by agreeing to buy Vigil Neuroscience Inc. for $8 per share (NASDAQ:VIGL). Included in the transaction is a non-tradeable contingent value right entitling the holder to potentially collect $2 per share more in cash, payable following the first commercial sale of the phase II-ready VG-3927, a small-molecule triggering receptor expressed on myeloid cells 2 (TREM2) antagonist for Alzheimer’s disease, if achieved within a specific period. Watertown, Mass.-based Vigil’s stock closed May 22 at $7.88, up $5.57, or 241%.
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