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Home » colorectal cancer

Articles Tagged with ''colorectal cancer''

More China ADCs: Arrivent gets GI cancer drug in $1.2B Lepu deal

Jan. 22, 2025
By Marian (YoonJee) Chu
A year after its $175 million IPO in 2024, Arrivent Biopharma Inc. picked up rights to develop and commercialize Lepu Biopharma Co. Ltd.’s antibody-drug conjugate (ADC) candidate, MRG-007, worldwide excluding the greater China region.
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Floating antibody drug conjugates
Immuno-oncology

Arrivent Biopharma licenses ex-China rights to Lepu’s ADC for gastrointestinal cancers

Jan. 22, 2025
Arrivent Biopharma Inc. has entered into an exclusive license agreement with Lepu Biopharma Co. Ltd. for MRG-007, an antibody-drug conjugate (ADC) in development for gastrointestinal cancers.
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Cancer

Combination of TB-01 and TAS-102 enhances colorectal cancer treatment in preclinical model

Jan. 21, 2025
Colorectal cancer remains the third most common malignancy worldwide, with advanced stages presenting significant challenges for treatment. A recently published study highlights the potential of combining the antiangiogenic peptide TB-01 (PEP-06), a drug in phase II studies in China, with the approved cytotoxic drug trifluridine/tipiracil (TAS-102) as a treatment for colorectal cancer.
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Colorectal cancer 3D illustration
Cancer

Multitarget kinase inhibitor shows efficacy in PDX-derived colorectal cancer cells

Jan. 20, 2025
Researchers from the National Health Research Institutes of Taiwan described the efficacy of BPR1J481, a multitarget tyrosine kinase inhibitor in PDX-derived colorectal cancer cells, which retain the original PDX tumor characteristics.
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Cancer

Oxford Drug Design validates novel approach in mouse model of colorectal cancer

Jan. 16, 2025
Oxford Drug Design Ltd. has announced additional in vivo validation for its novel approach against cancer. The innovative approach, using generative AI capabilities, is based on the novel target leucyl-tRNA synthetase.
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Lab glassware and antibodies art concept
Immuno-oncology

Sotio licenses fully human antibodies from Biocytogen to support SOT-109 development

Jan. 10, 2025
Sotio Biotech AS has announced the licensing of fully human antibodies from Biocytogen Pharmaceuticals (Beijing) Co. Ltd.
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Early data validate Vir’s newly acquired dual-masked TCE therapies

Jan. 8, 2025
By Jennifer Boggs
Vir Biotechnology Inc.’s 2024 deal with Sanofi SA is starting to look like a pretty savvy move. The company, which picked up three clinical-stage dual-masked T-cell engagers (TCEs) and rights to the platform technology as part of a pipeline overhaul, reported phase I data for TCE programs targeting HER2 and PSMA that indicated promising efficacy with a low prevalence of the cytokine toxicity that has hampered other TCE programs.
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Immuno-oncology

SYS-6045 cleared for clinic in China for advanced solid tumors

Jan. 8, 2025
CSPC Pharmaceutical Group Ltd.’s antibody-drug conjugate SYS-6045 has been granted clearance by China’s National Medical Products Administration (NMPA) to enter clinical trials.
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Colorectal cancer illustration
Cancer

Pattern Computer advances target and drug discovery in aggressive and early-onset colorectal cancer

Nov. 28, 2024
The company analyzed genomic data provided by the Fred Hutch Cancer Center and compiled by the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) to identify mutational signatures and single nucleotide polymorphisms (SNPs) predictive of colorectal cancer.
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Frank Borriello, CEO, Alloplex
Newco news

Alloplex’s Suplexa reawakens immune cells to fight cancer

Nov. 26, 2024
By Tamra Sami
When it comes to cell therapy, Alloplex Biotherapeutics Inc. CEO Frank Borriello said he believes that autologous, personalized therapy is the only thing that makes sense. “The allure of an off-the-shelf therapy has been such a magnet. It sucked in a lot of companies into that dream, and I'm sorry to say, it hasn't really worked out for them,” he told BioWorld. Instead, Borriello said he envisioned a cell training platform that doesn’t just tweak a single immune pathway but instead harnesses multiple immune pathways to turn the tables on cancer.
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