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Home » colorectal cancer

Articles Tagged with ''colorectal cancer''

Cancer

ERRγ has oncogenic role in colorectal cancer

July 2, 2024
A group of researchers in India have looked into the role of estrogen-related receptor γ (ERRγ) in the progression of colorectal cancer (CRC), and studied the effect of combination therapy with an ERRγ inverse agonist, DN-200434, and the AKT inhibitor MK-2206 in in vitro and in vivo assays.
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Cancer

Shenzhen Zhongge Biotechnology describes new KIF18A inhibitors

July 1, 2024
Shenzhen Zhongge Biotechnology Co. Ltd. has identified kinesin-like protein KIF18A inhibitors reported to be useful for the treatment of cancer.
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Human colon cancer cells.
Cancer

JD-02 induces cytoprotective autophagy in colorectal cancer models

June 28, 2024
Since heat shock protein 90 (Hsp90) is highly overexpressed in cancer, it is considered both a tumor marker and a therapeutic target for intervention.
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Colorectal cancer 3D illustration
Cancer

Novel STAT3 inhibitor exerts antitumor activity in colorectal cancer models

June 27, 2024
Signal transducer and activator of transcription 3 (STAT3) plays a key role in cell proliferation observed in colorectal cancer (CRC), where up-regulation of STAT3 accelerates tumorigenesis and promotes metastasis.
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Microscope with laptop displaying histology image.
Cancer

Genfleet’s KRAS G12D inhibitor GFH-375 receives NMPA clearance to enter clinic in China

June 20, 2024
Genfleet Therapeutics (Shanghai) Co. Ltd. has obtained clearance from China’s National Medical Products Administration (NMPA) to advance GFH-375 (VS-7375) into a phase I/II study in patients with advanced solid tumors with KRAS G12D mutation.
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Immuno-oncology

Odimma’s anti-CTLA-4 biologic ODI-2001 shows promise for treating cancer

June 7, 2024
Odimma Therapeutics SAS has developed ODI-2001, a new biological from the combination of neoantigen-expressing DNA vector, an anti-CTLA-4 antibody and an attenuated poxvirus with the aim of increasing the immune response against tumors.
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guardant bloodkit

Guardant wins over an FDA advisory panel for Shield CRC test

May 24, 2024
By Mark McCarty
The U.S. FDA’s May 23 advisory hearing for the Shield test for colorectal cancer by Guardant Health Inc., included the expected debate over whether patients would abandon colonoscopy thanks to the advent of a new blood-based test. While much of that debate was fed by what some saw as the test’s poor performance regarding adenoma, the advisory committee voted 6-3 that the benefits outweigh the risks in a decision the FDA is likely to affirm.
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U.S. FDA headquarters

Guardant wins over FDA advisory panel for Shield CRC test

May 23, 2024
By Mark McCarty
The U.S. FDA’s May 23 advisory hearing for the Shield test for colorectal cancer by Guardant Health Inc., included the expected debate over whether patients would abandon colonoscopy thanks to the advent of a new blood-based test. While much of that debate was fed by what some saw as the test’s poor performance with regard to adenoma, the advisory committee voted 7-2 that the benefits outweigh the risks in a decision the FDA is likely to affirm.
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Colon cancer illustration

FDA greenlights Geneoscopy’s Colosense colorectal cancer screening test

May 8, 2024
By Annette Boyle
This time a positive result for a cancer screening test brought good news, as Geneoscopy Inc. secured U.S. FDA approval for its RNA screening test for colorectal cancer. The agency based its decision on strong results from the phase III CRC-PREVENT trial in its approval of the noninvasive test for use in individuals aged 45 years and older with average risk for the disease.
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Colorectal cancer illustration
Cancer

CLZX-205, a novel CDK9 inhibitor with potent activity in colorectal cancer models

April 29, 2024
Researchers from Shenyang Pharmaceutical University and affiliated organizations have reported the identification of a selective cyclin-dependent kinase 9 (CDK9) inhibitor, CLZX-205, being developed for the treatment of colorectal cancer.
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