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Home » iPSCs

Articles Tagged with ''iPSCs''

Induced pluripotent stem cells
Newco news

Series A readies Rxcell's iPSC-derived photoreceptors for clinic

April 16, 2024
By Tamra Sami
On the heels of a $4.6 million series A round in December 2023, cell therapy company Rxcell Inc. is planning to raise another $15 million in 2024 to take its iPSC-derived photoreceptors to the clinic for retinitis pigmentosa and other degenerative diseases of the retina.
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Induced pluripotent stem cells
Newco news

Series A readies Rxcell's iPSC-derived photoreceptors for clinic

April 10, 2024
By Tamra Sami
On the heels of a $4.6 million series A round in December 2023, cell therapy company Rxcell Inc. is planning to raise another $15 million in 2024 to take its iPSC-derived photoreceptors to the clinic for retinitis pigmentosa and other degenerative diseases of the retina.
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Induced pluripotent stem cells
Neurology/Psychiatric

Kenai secures $82M to move iPSC drug for Parkinson’s into phase I

Feb. 29, 2024
By Karen Carey
San Diego-based Kenai Therapeutics Inc. raised $82 million in a series A round to move its disease-modifying cell therapy for Parkinson’s disease into the clinic. The company, which leverages induced pluripotent stem cell (iPSC) technology, will advance its next-generation allogeneic neuron replacement cell therapies for neurological diseases, specifically completing a clinical proof-of-concept trial for its lead candidate, RNDP-001. The series A was co-led by Alaska Permanent Fund Corp., Cure Ventures and The Column Group, with participation from Euclidean Capital and Saisei Ventures. Proceeds will enable Kenai to submit an IND for RNDP-001 and bring it through the completion of phase I trials, which are expected to begin sometime in 2024.
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Kenai secures $82M to move iPSC drug for Parkinson’s into phase I

Feb. 29, 2024
By Karen Carey
San Diego-based Kenai Therapeutics Inc. raised $82 million in a series A round to move its disease-modifying cell therapy for Parkinson’s disease into the clinic. The company, which leverages induced pluripotent stem cell (iPSC) technology, will advance its next-generation allogeneic neuron replacement cell therapies for neurological diseases, specifically completing a clinical proof-of-concept trial for its lead candidate, RNDP-001.
Read More
Lung illustration

Damaged lungs can be renewed by engrafting stem cells

Aug. 28, 2023
By Subhasree Nag
One of the key advances in regenerative medicine has been the engraftment of external epithelial stem cells to supplement or replace damaged native cells. However, the difficulty in engrafting internal tissues has hindered the long-term rescue of diseased internal epithelia, such as those in the respiratory airways.
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Lung illustration
Respiratory

Damaged lungs can be renewed by engrafting stem cells

Aug. 28, 2023
By Subhasree Nag
One of the key advances in regenerative medicine has been the engraftment of external epithelial stem cells to supplement or replace damaged native cells. However, the difficulty in engrafting internal tissues has hindered the long-term rescue of diseased internal epithelia, such as those in the respiratory airways.
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Immuno-oncology

Qihan’s gene-edited iPSC-derived cell therapy product QN-019a allowed to enter clinic in China

July 19, 2023
Hangzhou Qihan Biotech Co. Ltd. has received clinical trial clearance from China’s National Medical Products Administration (NMPA) for QN-019a for CD19-positive relapsed/refractory aggressive B-cell non-Hodgkin lymphoma.
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Immuno-oncology

Lift successfully produces first-in-class neutrophil-based cell therapy from iPSCs

July 6, 2023
Lift Biosciences Ltd. has announced successful proof-of-concept production of its patented cancer-killing alpha neutrophils from induced pluripotent stem cells (iPSCs). The proof of concept using In-Lift, the company’s second-generation platform which is derived from iPSCs, has shown that the alpha neutrophil type cells produced from iPSCs are able to be activated by chemokines released by tumors and that the cells actively destroy cancer cells.
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Cancer stem cells
Cancer

IPSirius targets cancer stem cells with iPSC-based vaccine

July 5, 2023
By Cormac Sheridan
IPSirius SAS, an early stage French immuno-oncology firm, hopes to obtain a clinical trial authorization from the U.K.’s Medicines and Healthcare Regulatory Products Agency next year, to enable it to move its novel therapeutic cancer vaccine into a first-in-human trial in patients with non-small-cell lung cancer.
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Healios, Sumitomo begin phase I/II trial of allogeneic iPS cells in retinal pigment epithelium tears

June 27, 2023
By Tamra Sami
Japan’s Pharmaceutical and Medical Devices Agency has cleared Healios K.K. and Sumitomo Pharma Co. Ltd. to begin a phase I/II study of HLCR-011, which is composed of retinal pigment epithelial (RPE) cells derived from allogeneic induced pluripotent stem cells (iPS) in patients with RPE tear.
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