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Home » iPSCs

Articles Tagged with ''iPSCs''

Healios, Sumitomo begin phase I/II trial of allogeneic iPS cells in retinal pigment epithelium tears

June 23, 2023
By Tamra Sami
Japan’s Pharmaceutical and Medical Devices Agency has cleared Healios K.K. and Sumitomo Pharma Co. Ltd. to begin a phase I/II study of HLCR-011, which is composed of retinal pigment epithelial (RPE) cells derived from allogeneic induced pluripotent stem cells (iPS) in patients with RPE tear.
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Cancer stem cells
Newco news

IPSirius targets cancer stem cells with iPSC-based vaccine

June 23, 2023
By Cormac Sheridan
IPSirius SAS, an early stage French immuno-oncology firm, hopes to obtain a clinical trial authorization from the U.K.’s Medicines and Healthcare Regulatory Products Agency next year, to enable it to move its novel therapeutic cancer vaccine into a first-in-human trial in patients with non-small-cell lung cancer.
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Cardiovascular

Advances in regenerative medicine for cardiovascular repair

June 23, 2023
By Mar de Miguel
Over the past decade there has been much research into the use of induced pluripotent stem cells (iPSCs) as a cell therapy to regenerate tissue and treat heart disease. Now, one researcher has narrowed the focus down to treating heart disease not with whole cells, but with mitochondria derived from iPSCs. Gentaro Ikeda, a researcher at the Department of Medicine at Stanford University, has worked on generating extracellular vesicles (EVs) containing mitochondria from pluripotent stem cell-derived cardiomyocytes and administering these to restore the functionality of the myocardium in a porcine model of an infarct.
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Drug Design, Drug Delivery & Technologies

Molecular changes reveal distinct phases in iPSCs that explain their pluripotency

June 21, 2023
By Mar de Miguel
Several developmental biology and regenerative medicine laboratories that use cellular reprogramming techniques presented their latest results on the differences in the states of induced pluripotent stem cells (iPSCs) during a Plenary Session on “Epigenetic regulation of distinct cell states” at the Annual Meeting of the International Society for Stem Cell Research (ISSCR), in Boston from June 14 to 17, 2023.
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Heartseed raises ¥2B to continue trials of iPSC-derived cardiomyocytes for heart failure

May 30, 2023
By Tamra Sami
Heartseed Inc. raised ¥2 billion (US$14.3 million) in a series D round to continue the phase I/II Lapis trial of its allogeneic induced pluripotent stem cell (iPSC)-derived cardiomyocytes for heart failure. The lead asset, HS-001, is an investigational cell therapy consisting of clusters of purified heart muscle cells (cardiomyocyte spheroids) derived from iPSCs that are designed to restore heart muscle and function in patients with advanced heart failure.
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Heartseed raises ¥2B to continue trials of iPSC-derived cardiomyocytes for heart failure

May 26, 2023
By Tamra Sami
Heartseed Inc. raised ¥2 billion (US$14.3 million) in a series D round to continue the phase I/II Lapis trial of its allogeneic induced pluripotent stem cell (iPSC)-derived cardiomyocytes for heart failure. The lead asset, HS-001, is an investigational cell therapy consisting of clusters of purified heart muscle cells (cardiomyocyte spheroids) derived from iPSCs that are designed to restore heart muscle and function in patients with advanced heart failure.
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Greater horseshoe bats hanging in cave
Infection

Bat cell line reveals unusual molecular relationship with viruses

Feb. 28, 2023
By Helen Albert
An international team of researchers has created two bat stem cell lines that reveal an unusual number of viral sequences in bat cells compared with those of other mammals. Writing in an article posted online Feb. 21, 2023, in Cell, the scientists suggested that the unusual amount of viral genetic material found in the bat stem cells could explain why these mammals are largely unaffected by most viral infections, despite being able to transmit them.
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Greater horseshoe bats hanging in cave
Infection

Bat cell line reveals unusual molecular relationship with viruses

Feb. 22, 2023
By Helen Albert
An international team of researchers has created two bat stem cell lines that reveal an unusual number of viral sequences in bat cells compared with those of other mammals. Writing in an article posted online Feb. 21, 2023, in Cell, the scientists suggested that the unusual amount of viral genetic material found in the bat stem cells could explain why these mammals are largely unaffected by most viral infections, despite being able to transmit them.
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Parkinson's disease illustration showing neurons containing alpha-synuclein
Neurology/Psychiatric

Ryne's development of RNDP-001 for Parkinson's disease supported by CIRM grant

Feb. 15, 2023
Ryne Biotechnology Inc. has been awarded a US$4 million Clinical Stage Research Program (CLIN1) grant by the California Institute for Regenerative Medicine (CIRM) to advance its lead candidate RNDP-001 through IND submission in the next 12 months.
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Neuron

New screening platform reveals neurodegeneration drug targets in microglia

Aug. 12, 2022
By Nuala Moran
As the resident innate immune cells of the brain, microglia are emerging as key drivers of neurological diseases, but as yet there is no systematic way of exploring their potential as drug targets.
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