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Home » SARS-CoV-2

Articles Tagged with ''SARS-CoV-2''

Antibodies block virus from cell
Infection

New computationally designed antigen targeting multiple sarbecoviruses shows in vivo efficacy

Sep. 29, 2023
Viruses of the Betacoronavirus genus that bind to angiotensin-converting enzyme 2 (ACE2) are the coronaviruses posing the most significant pandemic risk. Sarbecoviruses of this genus caused the severe acute respiratory syndrome (SARS) epidemic and the SARS-CoV-2 pandemic. Therefore, new vaccines with broader protection from ACE2-binding sarbecoviruses and emerging variants of concern are urgently needed.
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Infection

Targeting TBK1 and IKKε with synthetic flavonoid reduces COVID-19-like immunopathology in a mouse model

Sep. 26, 2023
TANK-binding kinase 1 (TBK1) serves prominent innate immune functions via complex interactions with adaptor proteins to affect phosphorylation of NF-κB (NF-κB). TBK1 is at the nexus of multiple pathways connecting interferon pathway activation and this is ultimately beneficial or hyperinflammatory-pathological in the context of viral infections.
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Infection

Westvac Biopharma discovers new Mpro inhibitors for SARS-CoV-2

Sep. 22, 2023
Westvac Biopharma Co. Ltd. has described keto amide derivatives acting as 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Infection

Versitech and Ningbo Combireg Pharmaceutical patent benzothiazole compounds to treat SARS-CoV-2

Sep. 21, 2023
Researchers at Ningbo Combireg Pharmaceutical Technology Co. Ltd. and Versitech Ltd. have described benzothiazole compounds reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Coronavirus variants
Infection

Discovery of a new α-ketoamide derivative as a selective SARS-CoV-2 Mpro inhibitor

Sep. 15, 2023
Novel effective antivirals against SARS-CoV-2 are needed because of the emergence of novel variants and the potential risk of SARS-CoV-2/MERS-CoV recombination. The SARS-CoV-2 main protease (Mpro) is a promising antiviral target. Mpro presents a His41-Cys145 catalytic dyad in the central part of its active site, which confers a natural advantage for developing covalent drugs.
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Infection

Mpro inhibitors described in Medshine Discovery patent

Sep. 14, 2023
Research at Medshine Discovery Inc. has led to the development of 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors potentially useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Infection

Arbutus Biopharma presents new RNA polymerase inhibitors for coronavirus infection

Sep. 7, 2023
Arbutus Biopharma Corp. has divulged RNA polymerase inhibitors reported to be useful for the treatment of coronavirus infection.
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Infection

SARS-CoV-2 Mpro inhibitors reported in Wistar Institute of Anatomy & Biology patent

Aug. 31, 2023
Wistar Institute of Anatomy & Biology has synthesized new 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors for the treatment of SARS-CoV-2 infection (COVID-19).
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Colorized transmission electron micrograph of SARS-CoV-2.
Infection

Next-generation oral SARS-CoV-2 Mpro inhibitor disclosed

Aug. 29, 2023
Viral proteases are well-established therapeutic targets in HIV and hepatitis C virus infections. Following the recent COVID-19 pandemic, one of the strategies in place is SARS-CoV-2 main protease (Mpro) inhibition, given the crucial role of SARS-CoV-2 Mpro in the replication of the virus.
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Microscope and coronavirus illustration
Infection

Complement dysregulation is key feature of severe COVID-19

Aug. 24, 2023
By Helen Albert
Research led by investigators at Ghent University in Belgium showed dysregulation of the complement part of the immune system, regulated by the pro-inflammatory protein interleukin (IL)-6, is a key driver of severe COVID-19 and a good target for drugs to treat the effects of the disease. Writing in the Aug. 23, 2023, issue of Science Translational Medicine, the researchers also described a cellular map of the alterations seen in the complement system during COVID-19 related respiratory deterioration for use in future research.
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