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Home » SARS-CoV-2

Articles Tagged with ''SARS-CoV-2''

Art concept for HLA-B*15:01 fighting SARS-CoV-2
Infection

HLA variation linked to asymptomatic COVID infection

July 19, 2023
By Subhasree Nag
Since its emergence in late 2019, SARS-CoV-2 has killed nearly 7 million people. But at the same time, many infections, in particular in children and young adults, are asymptomatic with rapid viral clearance from the body. It remains unclear why many individuals are able to successfully clear infection without major complications while others develop severe disease, even without known risk factors for severe COVID-19 outcomes.

Now, a new study involving nearly 30,000 individuals has found that variation in the human leukocyte antigen (HLA) loci may underlie processes mediating asymptomatic infection. The findings were reported in the July 19, 2023, online edition of Nature.
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Infection

Pharmablock Sciences patents Mpro inhibitors for treatment of viral infections

July 17, 2023
Research at Pharmablock Sciences (Nanjing) Inc. has led to the development of spirooxindole compounds acting as 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors and thus reported to be useful for the treatment of viral infections.
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Coronavirus vaccine illustration
Infection

OVX-033 vaccine exhibits broad protection against SARS-CoV-2 in preclinical models

July 11, 2023
The protection against SARS-CoV-2 provided by spike-based vaccines, although effective, tends to decrease as the virus evolves and new variants of concern appear. Researchers from Osivax SAS reported the first results on cross-protection with OVX-033, a new human SARS-CoV-2 vaccine generated via the oligoDOM platform.
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Creative rendition of SARS-CoV-2 virus particles.
Infection

Targeting nuclear ACE2 induces a protective epigenetic signature against SARS-CoV-2 in vivo

July 10, 2023
The search for novel therapies that complement vaccine-induced immune protection against SARS-CoV-2 continues. In previous work, researchers at QIMR Berghofer Medical Research Institute and collaborators developed a cell-permeable and highly selective peptide called NACE2i, targeting nuclear angiotensin-converting enzyme 2 (ACE2). In particular, NACE2i spans and targets the ACE2 nuclear localization signal motif, successfully inhibiting nuclear translocation of ACE2 and viral replication in human cell lines infected with SARS-CoV-2.
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Diagnostics

Helmholtz Zentrum Dresden Rossendorf reports PD-L1-targeting radiolabeled compounds

July 7, 2023
Helmholtz Zentrum Dresden Rossendorf has patented 3-((3-([1,1’-biphenyl]-3-ylmethoxy)phenoxy)methyl)benzonitrile derivatives that are radiolabeled compounds targeting programmed cell death 1 ligand 1 (PD-L1; CD274). They are reported to be potentially useful for the diagnosis and/or radionuclide therapy treatment of cancer and SARS-CoV-2.
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Infection

Scripps Research Institute discovers new antiviral prodrugs for SARS-CoV-2

June 29, 2023
Scripps Research Institute has described nucleoside analogues acting as prodrugs reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Drug vial and syringe
Immune

SARS-CoV-2/flu two-hit protective vaccine developed based on RBD conjugated with inactivated influenza A virus

June 28, 2023
SARS-CoV-2 and influenza (flu) viruses share similar clinical manifestations, common transmission mechanisms and target tissues, often overlapping during seasonal outbreaks. In addition, co-infection of these viruses worsens disease severity, emphasizing the pressing need for a vaccine that effectively tackles both.
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Infection

Enanta divulges new 3CLpro inhibitors

June 26, 2023
Enanta Pharmaceuticals Inc. has synthesized spirocyclic compounds acting as 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of coronavirus acute respiratory syndrome.
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Infection

Institute for Drug Research patent describes SARS-CoV-2 Mpro inhibitors

June 19, 2023
The Institute for Drug Research has patented pyrrolidine antiviral compounds acting as 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors.
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Creative rendition of SARS-CoV-2 virus particles.
Infection

Inhibition of aryl hydrocarbon receptor reduces SARS-CoV-2 replication, ameliorates COVID-19 pathology

June 19, 2023
Having caused over 6.2 million deaths globally ongoing, the COVID-19 pandemic since 2020 continues to pose a serious public health challenge. While the SARS-CoV-2 receptors angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 play requisite roles in permitting the initial infection, up to 10 proviral host factors have also been determined to play crucial roles in controlling the viral replication, but most are not pharmacologically targetable.
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