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Home » SARS-CoV-2

Articles Tagged with ''SARS-CoV-2''

Diagnostics

Helmholtz Zentrum Dresden Rossendorf reports PD-L1-targeting radiolabeled compounds

July 7, 2023
Helmholtz Zentrum Dresden Rossendorf has patented 3-((3-([1,1’-biphenyl]-3-ylmethoxy)phenoxy)methyl)benzonitrile derivatives that are radiolabeled compounds targeting programmed cell death 1 ligand 1 (PD-L1; CD274). They are reported to be potentially useful for the diagnosis and/or radionuclide therapy treatment of cancer and SARS-CoV-2.
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Infection

Scripps Research Institute discovers new antiviral prodrugs for SARS-CoV-2

June 29, 2023
Scripps Research Institute has described nucleoside analogues acting as prodrugs reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Drug vial and syringe
Immune

SARS-CoV-2/flu two-hit protective vaccine developed based on RBD conjugated with inactivated influenza A virus

June 28, 2023
SARS-CoV-2 and influenza (flu) viruses share similar clinical manifestations, common transmission mechanisms and target tissues, often overlapping during seasonal outbreaks. In addition, co-infection of these viruses worsens disease severity, emphasizing the pressing need for a vaccine that effectively tackles both.
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Infection

Enanta divulges new 3CLpro inhibitors

June 26, 2023
Enanta Pharmaceuticals Inc. has synthesized spirocyclic compounds acting as 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of coronavirus acute respiratory syndrome.
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Infection

Institute for Drug Research patent describes SARS-CoV-2 Mpro inhibitors

June 19, 2023
The Institute for Drug Research has patented pyrrolidine antiviral compounds acting as 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors.
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Creative rendition of SARS-CoV-2 virus particles.
Infection

Inhibition of aryl hydrocarbon receptor reduces SARS-CoV-2 replication, ameliorates COVID-19 pathology

June 19, 2023
Having caused over 6.2 million deaths globally ongoing, the COVID-19 pandemic since 2020 continues to pose a serious public health challenge. While the SARS-CoV-2 receptors angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 play requisite roles in permitting the initial infection, up to 10 proviral host factors have also been determined to play crucial roles in controlling the viral replication, but most are not pharmacologically targetable.
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Coronavirus and antibodies
Infection

New multispecific antibody platform offers increased potency and breadth against SARS-CoV-2

June 7, 2023
Scientists from the Hospital for Sick Children Research Institute and collaborators have reported the application of a multispecific, multiaffinity antibody (Multabody, MB) platform derived from the human apoferritin protomer to enable the multimerization of antibody fragments against SARS-CoV-2. These MBs showed high potency to neutralize SARS-CoV-2 even at lower concentrations than their corresponding MAb counterparts.
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European flag, vial, syringe

COVID-19 vaccines get seasonal treatment as EMA issues recommendations for 2023-2024

June 6, 2023
By Nuala Moran
The EMA and the European Center for Disease Control have said COVID-19 vaccine manufacturers should ditch the existing formulations and adapt their products to target the omicron-descendant XBB.1.5, to protect against SARS-CoV-2 in the winter of 2023–2024.
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Infection

Suzhou Spring-Sea Bio-Pharmaceuticals reports identification of prodrugs for treatment of COVID-19

June 6, 2023
Suzhou Spring-Sea Bio-Pharmaceuticals Co. Ltd. has prepared and tested prodrugs of N4-hydroxycytidine (NHC) that are reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Infection

Enanta Pharmaceuticals patents SARS-CoV-2 Mpro inhibitors

June 6, 2023
Several recent Enanta Pharmaceuticals Inc...
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