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Home » SARS-CoV-2

Articles Tagged with ''SARS-CoV-2''

Respiratory infection
Infection

Tetra reports AI study results of ARDS-003 in combination with favipiravir

Dec. 7, 2022
Tetra Bio-Pharma Inc. has reported results from a study of ARDS-003 (onternabez) combined with favipiravir against acute respiratory distress syndrome (ARDS), sepsis and COVID-19 through PREPAiRE, an artificial intelligence (AI)-powered platform which integrates target identification, validation, lead discovery optimization, drug synthesis and preclinical testing.
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Microscope and coronavirus illustration
Infection

Pfizer and Clear Creek collaborate on SARS-CoV-2 PLpro inhibitors for COVID-19

Dec. 7, 2022
Pfizer Inc. and Clear Creek Bio Inc. have entered into a research collaboration and exclusive license agreement to advance the discovery and development of potential inhibitors of the SARS-CoV-2 papain-like protease (PLpro) for the oral treatment of COVID-19.
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Gloved hand holding COVID-19 vaccine vial, syringe
Infection

CEPI and VBI expand scope of partnership to target coronavirus threats

Dec. 7, 2022
The Coalition for Epidemic Preparedness Innovations (CEPI) has expanded its partnership with VBI Vaccines Inc. to advance the development of multivalent coronavirus vaccines that could be deployed against COVID-19 and possible future coronaviruses with pandemic potential, referred to as coronavirus X.
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Kineret-box-and-syringe

Bebtelovimab out, Kineret in, as US and globe fight to end the pandemic

Dec. 6, 2022
By Karen Carey
The world is emerging from the COVID-19 pandemic, as both cases and deaths have remained consistently low in recent months, despite continuous mutation of the SARS-CoV-2 virus. Nevertheless, there is a shuffling of candidates in the arsenal as new variants bump once-effective therapies and the next generation of options enter the arena.
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Illustration of the spike glycoprotein structure of SARS-CoV and linoleic acid molecules.
Infection

Conserved binding pocket is net positive for deadly coronavirus strains

Dec. 5, 2022
By Anette Breindl
Investigators at the University of Bristol and Biognos AB have identified a structural feature that distinguished the deadly coronavirus strains from harmless, common cold-causing variants. The findings, which were published in the Nov. 23, 2022, issue of Science Advances, could form the basis of universal COVID antivirals, putting an end to the endless race to deal with new variants that has so far been a necessity.
Read More
Kineret-box-and-syringe

Bebtelovimab out, Kineret in, as US and globe fight to end the pandemic

Dec. 1, 2022
By Karen Carey
The world is emerging from the COVID-19 pandemic, as both cases and deaths have remained consistently low in recent months, despite continuous mutation of the SARS-CoV-2 virus. Nevertheless, there is a shuffling of candidates in the arsenal as new variants bump once-effective therapies and the next generation of options enter the arena.
Read More
Infection

Quantbiores patents SARS-CoV-2 spike glycoprotein/ACE2 interaction inhibitors

Dec. 1, 2022
Quantbiores A/S has discovered peptides acting as spike glycoprotein (S) (SARS-CoV-2)/ACE2 interaction inhibitors reported to be useful for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19).
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Infection

Texas A&M University System divulges new SARS-CoV-2 3CLpro and CYP3A4 inhibitors

Nov. 30, 2022
Texas A&M University System has discovered 3C-like proteinase (3CLpro) (SARS-CoV-2; COVID-19 virus) and cytochrome P450 3A4 (CYP3A4) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection.
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Three alpacas
Infection

Biondvax reports in vivo data with inhaled NanoAb COVID-19 therapy

Nov. 30, 2022
Biondvax Pharmaceuticals Ltd. has reported statistically significant efficacy results from an in vivo proof-of-concept study of its innovative inhaled nanosized antibody (NanoAb) COVID-19 therapy.
Read More
Illustration of the spike glycoprotein structure of SARS-CoV and linoleic acid molecules.
Infection

Conserved binding pocket is net positive for deadly coronavirus strains

Nov. 28, 2022
By Anette Breindl
Investigators at the University of Bristol and Biognos AB have identified a structural feature that distinguished the deadly coronavirus strains from harmless, common cold-causing variants. The findings, which were published in the Nov. 23, 2022, issue of Science Advances, could form the basis of universal COVID antivirals, putting an end to the endless race to deal with new variants that has so far been a necessity.

The researchers showed that the same pocket, a binding site for linoleic acid (LA), was present in all variants of concern (VOCs) that have emerged since 2020. “Intriguingly, all SARS-CoV-2 VOCs stringently maintain this pocket, notably including Omicron, which accumulated a wide range of mutations in [the spike protein] elsewhere, suggesting that the pocket provides a selective advantage for the virus,” they wrote in their paper.
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