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Home » SARS-CoV-2

Articles Tagged with ''SARS-CoV-2''

Infection

Quantbiores patents SARS-CoV-2 spike glycoprotein/ACE2 interaction inhibitors

Dec. 1, 2022
Quantbiores A/S has discovered peptides acting as spike glycoprotein (S) (SARS-CoV-2)/ACE2 interaction inhibitors reported to be useful for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19).
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Infection

Texas A&M University System divulges new SARS-CoV-2 3CLpro and CYP3A4 inhibitors

Nov. 30, 2022
Texas A&M University System has discovered 3C-like proteinase (3CLpro) (SARS-CoV-2; COVID-19 virus) and cytochrome P450 3A4 (CYP3A4) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection.
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Three alpacas
Infection

Biondvax reports in vivo data with inhaled NanoAb COVID-19 therapy

Nov. 30, 2022
Biondvax Pharmaceuticals Ltd. has reported statistically significant efficacy results from an in vivo proof-of-concept study of its innovative inhaled nanosized antibody (NanoAb) COVID-19 therapy.
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Illustration of the spike glycoprotein structure of SARS-CoV and linoleic acid molecules.
Infection

Conserved binding pocket is net positive for deadly coronavirus strains

Nov. 28, 2022
By Anette Breindl
Investigators at the University of Bristol and Biognos AB have identified a structural feature that distinguished the deadly coronavirus strains from harmless, common cold-causing variants. The findings, which were published in the Nov. 23, 2022, issue of Science Advances, could form the basis of universal COVID antivirals, putting an end to the endless race to deal with new variants that has so far been a necessity.

The researchers showed that the same pocket, a binding site for linoleic acid (LA), was present in all variants of concern (VOCs) that have emerged since 2020. “Intriguingly, all SARS-CoV-2 VOCs stringently maintain this pocket, notably including Omicron, which accumulated a wide range of mutations in [the spike protein] elsewhere, suggesting that the pocket provides a selective advantage for the virus,” they wrote in their paper.
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Respiratory infection
Infection

Long lung COVID gives broader insights into fibrotic lung disease

Nov. 18, 2022
By Nuala Moran
An in-depth investigation of the underlying causes of pulmonary symptoms that in some cases persist for months following recovery from the acute stage of COVID-19 has found a distinctive proinflammatory signature in the plasma and airways of affected patients.
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Pregnant woman

Salignostics launches saliva-based home pregnancy test kit

Nov. 17, 2022
By Nuala Moran
The first home pregnancy test to analyze saliva rather than urine is due to be on the shelves in Europe at the start of 2023, following CE approval of Salistick, developed by saliva diagnostic specialist Salignostics Ltd.
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Immune

Pfizer and Biontech advance next-generation COVID-19 vaccine candidate into clinic

Nov. 17, 2022
Pfizer Inc. and Biontech SE have initiated a phase I study to evaluate the safety, tolerability and immunogenicity of BNT-162b4, a next-generation COVID-19 vaccine candidate that aims to enhance SARS-CoV-2 T-cell responses and potentially broaden protection against COVID-19.
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Infection

Long lung COVID gives broader insights into fibrotic lung disease

Nov. 17, 2022
By Nuala Moran
An in-depth investigation of the underlying causes of pulmonary symptoms that in some cases persist for months following recovery from the acute stage of COVID-19 has found a distinctive proinflammatory signature in the plasma and airways of affected patients. The research could provide an explanation for the ongoing interstitial lung disease and fibrosis seen in patients who were hospitalized with severe COVID-19, and also point to neutrophils as a specific therapeutic target.
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UK map and pharmaceuticals

NICE says no to five COVID-19 treatments in the UK

Nov. 16, 2022
By Lee Landenberger
Britain’s National Institute for Health and Care Excellence (NICE), a key gatekeeper on the path to the U.K. market, is backing away from five COVID-19 treatments. No longer recommended in a draft guidance were Ronapreve (casirivimab + imdevimab) from Roche Holding AG, Xevudy (sotrovimab) from GSK plc, and Evusheld (tixagevimab + cilgavimab) from Astrazeneca plc. NICE also recommended discontinuing use of Lagevrio (molnupiravir) from Merck and Co. Inc. and Veklury (remdesivir) from Gilead Sciences Inc.
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Infection

Novartis divulges antiviral compounds for COVID-19

Nov. 16, 2022
Novartis AG has described 3C-like proteinase (3CLpro) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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