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Home » neurodegenerative diseases

Articles Tagged with ''neurodegenerative diseases''

Neurology/Psychiatric

VHB-937, a TREM2-binding MAb with efficacy in a broad range of neurodegenerative disease models

March 11, 2024
It has been previously demonstrated that TREM2 is extensively shed during chronic neuroinflammation, which hiders its function, while TREM2 activation enhances effector functions of microglia.
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Brain
Neurology/Psychiatric

Brain-penetrant TYK2 inhibitor shows efficacy in models of neuroinflammation

March 5, 2024
Researchers from Alumis Inc. have presented preclinical data for a novel, potential first-in-class tyrosine kinase 2 (TYK2) inhibitor – A-005.
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NLRP3 inflammasome
Neurology/Psychiatric

Transthera’s CNS-penetrating NLRP3 inflammasome inhibitor enters IND-enabling studies

Feb. 27, 2024
Transthera Sciences (Nanjing) Inc. has announced the initiation of IND-enabling studies for TT-02332, a potent, selective and highly CNS-penetrating NLRP3 inflammasome inhibitor.
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SK-CC

Korea approves SK C&C’s AI solution to diagnose brain infarction

Feb. 22, 2024
By Marian (YoonJee) Chu
South Korea’s MFDS gave regulatory clearance to SK Inc. C&C’s artificial intelligence (AI) solution to diagnose cerebral infarction called Medical Insight+ Brain Infarct on Feb. 22, as a class III device.
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Antibodies
Neurology/Psychiatric

Vectory Therapeutics closes series A financing to advance vectorized antibody into clinic

Nov. 14, 2023
Vectory Therapeutics BV has closed a €129 million ($138 million) series A financing to advance its vectorized antibody programs in neurodegenerative diseases.
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Vuno

FDA clears Vuno’s AI-based MRI reading software for early Alzheimer’s detection

Oct. 25, 2023
By Marian (YoonJee) Chu
Vuno Inc. gained a U.S. FDA’s 510(k) clearance for its artificial intelligence (AI)-powered brain quantification device, Vuno Med-Deepbrain, to diagnose possible dementia in patients “even before mild cognitive impairment.”
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Elderly woman holding illustration of brain with missing puzzle piece

New blood test to detect Parkinson’s disease earlier

Sep. 14, 2023
By Shani Alexander
An international team of researchers have developed a new blood test that could detect Parkinson’s disease earlier than current methods. The test, a real-time PCR-based assay, called Mito Dnadx, uses blood to identify damage to mitochondrial DNA (mtDNA) caused by the neurodegenerative condition. Based on the findings published in the journal Science Translational Medicine, the test could allow rapid, noninvasive and accurate identification of Parkinson’s disease (PD) before it causes much damage to the nervous system.
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Twice as nice: With Alexion, Verge cuts another big AI deal

Sep. 8, 2023
By Lee Landenberger
Verge Genomics Inc. has entered a second big AI deal with a large drug company. Privately held Verge will receive up to $42 million, including up-front, equity and near-term payments from Alexion, Astrazeneca Rare Disease, to identify multiple targets for rare neurodegenerative and neuromuscular diseases. The deal could top out at $840 million. There also is potential for downstream royalties.
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Brain and blood cells

Alzheimer’s diagnostics advance in sync with treatments

July 21, 2023
By Nuala Moran
With the spotlight at this week’s Alzheimer’s Association International conference firmly fixed on the first approved therapies, advances in diagnosing the neurodegenerative disease - on which effective use of new drugs will hang - attracted less attention. However, hand-in-hand with the development of anti-amyloid drugs, development of blood-based biomarkers has made significant progress and they now have the potential to form the basis of easy to access and low cost tests.
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Neurology/Psychiatric

IRBM, Rainwater Charitable Foundation and Weill Cornell Medicine collaborate on cGAS inhibitors for tauopathies

July 12, 2023
IRBM SpA, Rainwater Charitable Foundation and...
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