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Home » neurodegenerative diseases

Articles Tagged with ''neurodegenerative diseases''

Aribio scores $770M deal in China for Alzheimer’s drug candidate

March 25, 2024
By Marian (YoonJee) Chu
South Korean biopharma Aribio Co. Ltd. signed a $770 million deal to sign off exclusive rights to its early Alzheimer’s disease drug, AR-1001 (mirodenafil), in China. The exclusive deal for marketing rights will total about ¥5.59 billion (US$770 million), which includes a non-refundable up-front payment of ₩120 billion (US$90 million) and potential milestone payments, along with royalties.
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Man piecing together a puzzle
Neurology/Psychiatric

Pharmacological miR-155 blockade restricts neurodegenerative pathology and preserves cognitive function in AD

March 13, 2024
In a new study, researchers from Harvard Medical School and Regulus Therapeutics Inc. further investigated the role of miR-155 in Alzheimer's disease (AD).
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Neurology/Psychiatric

STX-64 as potential new therapeutic approach for the treatment of AD and other cognitive-related diseases

March 12, 2024
The small-molecule steroid sulfatase (STS) inhibitor STX-64 (ONESTX-1, irosustat) previously showed a good safety and tolerability profile in several phase I and II clinical trials that evaluated the candidate for oncology indications.
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Neurology/Psychiatric

VHB-937, a TREM2-binding MAb with efficacy in a broad range of neurodegenerative disease models

March 11, 2024
It has been previously demonstrated that TREM2 is extensively shed during chronic neuroinflammation, which hiders its function, while TREM2 activation enhances effector functions of microglia.
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Brain
Neurology/Psychiatric

Brain-penetrant TYK2 inhibitor shows efficacy in models of neuroinflammation

March 5, 2024
Researchers from Alumis Inc. have presented preclinical data for a novel, potential first-in-class tyrosine kinase 2 (TYK2) inhibitor – A-005.
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NLRP3 inflammasome
Neurology/Psychiatric

Transthera’s CNS-penetrating NLRP3 inflammasome inhibitor enters IND-enabling studies

Feb. 27, 2024
Transthera Sciences (Nanjing) Inc. has announced the initiation of IND-enabling studies for TT-02332, a potent, selective and highly CNS-penetrating NLRP3 inflammasome inhibitor.
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SK-CC

Korea approves SK C&C’s AI solution to diagnose brain infarction

Feb. 22, 2024
By Marian (YoonJee) Chu
South Korea’s MFDS gave regulatory clearance to SK Inc. C&C’s artificial intelligence (AI) solution to diagnose cerebral infarction called Medical Insight+ Brain Infarct on Feb. 22, as a class III device.
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Antibodies
Neurology/Psychiatric

Vectory Therapeutics closes series A financing to advance vectorized antibody into clinic

Nov. 14, 2023
Vectory Therapeutics BV has closed a €129 million ($138 million) series A financing to advance its vectorized antibody programs in neurodegenerative diseases.
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Vuno

FDA clears Vuno’s AI-based MRI reading software for early Alzheimer’s detection

Oct. 25, 2023
By Marian (YoonJee) Chu
Vuno Inc. gained a U.S. FDA’s 510(k) clearance for its artificial intelligence (AI)-powered brain quantification device, Vuno Med-Deepbrain, to diagnose possible dementia in patients “even before mild cognitive impairment.”
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Elderly woman holding illustration of brain with missing puzzle piece

New blood test to detect Parkinson’s disease earlier

Sep. 14, 2023
By Shani Alexander
An international team of researchers have developed a new blood test that could detect Parkinson’s disease earlier than current methods. The test, a real-time PCR-based assay, called Mito Dnadx, uses blood to identify damage to mitochondrial DNA (mtDNA) caused by the neurodegenerative condition. Based on the findings published in the journal Science Translational Medicine, the test could allow rapid, noninvasive and accurate identification of Parkinson’s disease (PD) before it causes much damage to the nervous system.
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