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Home » Topics » Gastrointestinal, BioWorld MedTech

Gastrointestinal, BioWorld MedTech
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Businessman and IPO virtual screen

Caris settles IPO at $21, trading starts at $28

June 20, 2025
By Annette Boyle
Despite raising the price of its IPO twice, Caris Life Sciences Inc. left money on the table with a 33% increase in price as soon as trading commenced on the Nasdaq, though no one is squawking about raising nearly $500 million. The cancer diagnostics company initially priced its IPO at $16 to $18, then raised it to $19 to $20, before closing on a price of $21 per share. As management rang the bell for the start of trade on June 18, shares began trading at $28.
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Liver
Gastrointestinal

Precision medicine approach identifies culprit in alcohol-associated hepatitis

May 29, 2025
By Anette Breindl
No Comments
Researchers have identified KpsM as a virulence factor in Escherichia coli that was responsible for liver damage in alcohol-associated hepatitis (AH). A small-molecule inhibitor of KpsM reduced liver damage in animal models of AH.
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Liver illustration
Endocrine/metabolic

Liver is also immune organ, influenced by microbiome

May 14, 2025
By Anette Breindl
No Comments
Immunity is not a function most people particularly associate with the liver. But because of its connection to the gut, the liver is exposed to bacterial metabolites as few other organs are. And when either the liver or the gut is not functioning well, it can adversely affect immunity as well.
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Businessman and IPO virtual screen

Three med-tech IPOs on the horizon

May 13, 2025
By Annette Boyle
April may not have brought rain to med-tech, but tariffs and financial uncertainty certainly dampened the enthusiasm for IPOs. With those clouds lifting, three companies – Hinge Health Inc., Capsovision Inc., and Omada Health Inc. – appear ready to flower in May, potentially a harbinger of a return to the brisk pace for med-tech IPOs seen in the opening weeks of 2025 when eight companies raised nearly $1 billion.
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Colon cancer illustration

Safeheal secures €35M for endoluminal fecal bypass system

May 7, 2025
By Shani Alexander
Safeheal SAS raised €35 million (US$39.72 million) in an oversubscribed series C financing round for its temporary endoluminal fecal bypass system, Colovac, which is placed in the colon following colorectal resection. The funds will be used to complete an investigational device exemption pivotal study and speed up preparation for commercial launch of the device.
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Illustration of cell dividing
Cancer

Germline variants’ impact on pan-cancer proteome

April 25, 2025
By Mar de Miguel
A large-scale study has revealed the impact of germline variants on proteins in 10 cancer types. Scientists from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) conducted a precision proteogenomic analysis in a pan-cancer study with data from 1,064 patients, identifying tumor heterogeneity and tumorigenesis associated with heritable genetic alterations.
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Da Vinci Xi robot - Intuitive Surgical

J&J reports completion of first cases with Ottava robotic system

April 15, 2025
By Holland Johnson
Johnson & Johnson’s Medtech division reported the completion of the first cases in the clinical trial for the Ottava robotic surgical system. The cases mark the first clinical experience with the Ottava system, which has been a long time in development.
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Abstract illustration of pig and human with medical motifs
Drug design, drug delivery & technologies

Ten days of normal survival of a pig liver in a human being

March 28, 2025
By Mar de Miguel
Transplanting an animal organ into a human is now a closer reality following the successful xenotransplantation of a genetically modified pig liver into a patient diagnosed with brain death in China. The operation was intended to evaluate organ function over a 10-day period. This is a complex experimental trial that did not involve removing the patient's liver and still requires further study. However, the positive preclinical results suggest this strategy could save the lives of those waiting for a human organ, at least in certain cases.
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Toilets could be the next big health device: Medical Korea 2025

March 20, 2025
By Marian (YoonJee) Chu
Seung-min Park, professor at Nanyang Technological University and cofounder of Kanaria Health, is working to manufacture smart bidets that can capture biomarker data from urine and stool automatically and enable continuous monitoring.
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Microbiome illustration
Infection

Synthetic microbiome prevents Clostridioides difficile recurrences

March 7, 2025
By Coia Dulsat
Investigators at Pennsylvania State University have described a novel approach to combat Clostridioides difficile infection using a synthetic microbiome therapy, which offers an alternative to antibiotics and fecal microbiota transplant .
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