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Home » Topics » Diagnostics, BioWorld Science

Diagnostics, BioWorld Science
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Diagnostics

ETH Zürich and Roche divulge new MAGL inhibitors

May 8, 2025
Scientists at ETH Zürich, F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have synthesized fluorescent probes acting as monoglyceride lipase (MGLL; MAGL) inhibitors reported to be useful for diagnostic imaging of MAGL.
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Art concept for medical research
Substance use & poisoning

Ignite Biomedical, Liquid Biosciences discover new biomarkers for substance use disorder

April 9, 2025
Ignite Biomedical Inc. and Liquid Biosciences have announced the discovery of biomarkers to diagnose substance use disorder (SUD). The set of biomarkers includes some that have not previously been associated with addiction and spans all 6 SUDs (opioid, cocaine, methamphetamine, alcohol, nicotine and cannabis use disorders).
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Diagnostics

Astrogen patents new fluorescence imaging agents and photosensitizers

Feb. 28, 2025
Astrogen Co Ltd. has disclosed prodrugs of 5-aminolevulinic acid (5-ALA) derivatives acting as fluorescence imaging agents and photosensitizers in photodynamic therapy with improved storage stability, reported to be useful for diagnosis and treatment of cancer, aging, alopecia, insomnia, inflammatory and metabolic disorders.
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3D illustration showing presence of tumor inside prostate gland
Biomarkers

RNA panel detects and differentiates prostate cancer from benign prostate hyperplasia

Feb. 14, 2025
Prostate cancer is still one of the main causes of cancer death among men; while prostate-specific antigen (PSA) testing is done for screening, there are recommendations against its use due to its nonspecific and suboptimal results. There is thus an urgent need for new biomarkers that are more accurate in the detection of prostate cancer.
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Silhouette made of gears
Women's health

A blood test could identify postpartum depression risk

Feb. 6, 2025
By Annette Boyle
Curently the only available blood test to tell which women are at risk of postpartum depression (PPD) is the one that confirms their pregnancy – and a one in seven chance of developing the condition which can have long-term implications for both mother and child. Research out of the University of Virginia and Weill Cornell Medicine could soon change that by identifying biomarkers in the third trimester of pregnancy that indicate which women have the greatest risk of developing PPD.
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Brain scan illustration
Diagnostics

[18F]CNL-02, a PET radioligand for imaging MC-I in the brain

Feb. 6, 2025
Researchers from Massachusetts General Hospital and affiliated organizations have published preclinical data for [18F]CNL-02, a positron emission tomography (PET) radioligand targeting mitochondrial complex I (MC-I) that is being developed for the diagnosis of Alzheimer’s disease and other neurodegenerative disorders.
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Diagnostics

In vivo evaluation of novel CCR2 targeting radioligand reported

Feb. 5, 2025
Researchers from Astrazeneca plc and Karolinska Institutet have described the positron emission tomography (PET) evaluation of [11C]AZD-2423, a chemokine receptor type 2 (CCR2) radioligand in non-human primate (NHP) brain imaging. CCR2 is essential in immune cell migration control. It is mainly expressed in microglia and monocytes and closely linked to the brain’s immune defense.
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Cancer

MET-targeting theranostic antibody presented

Feb. 4, 2025
Mesenchymal-epithelial transition factor (MET) plays a relevant role in growth, survival, migration and tissue repair. Alterations in MET have been found in non-small-cell lung cancer and head and neck cancer, and are associated with aggressive and difficult-to-treat cancer types.
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Blood samples in lab
Drug design, drug delivery & technologies

Proteomics study explores how protein changes influence disease

Jan. 13, 2025
By Nuala Moran
Fourteen global pharma companies are getting together to conduct the largest proteomics study to date, analyzing 600,000 blood samples held in the UK Biobank to assess the levels of 5,400 different proteins.
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Tau neuron illustration
Diagnostics

[18F]FA1, a tau-PET radiotracer with excellent affinity and selectivity

Jan. 13, 2025
Work at Beijing Normal University and affiliated organizations has led to the discovery and preclinical characterization of a novel tau-PET radiotracer for Alzheimer’s disease (AD).
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