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Home » Topics » Drug design, drug delivery and technologies, BioWorld Asia

Drug design, drug delivery and technologies, BioWorld Asia
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Abstract illustration of pig and human with medical motifs
Drug design, drug delivery & technologies

Ten days of normal survival of a pig liver in a human being

April 1, 2025
By Mar de Miguel
Transplanting an animal organ into a human is now a closer reality following the successful xenotransplantation of a genetically modified pig liver into a patient diagnosed with brain death in China. The operation was intended to evaluate organ function over a 10-day period. This is a complex experimental trial that did not involve removing the patient's liver and still requires further study. However, the positive preclinical results suggest this strategy could save the lives of those waiting for a human organ, at least in certain cases.
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3D illustration of RNA
Neurology/psychiatric

Ono and Reborna partner to discover RNA-targeting small molecules for neurological disorders

April 1, 2025
Ono Pharmaceutical Co. Ltd. has entered into a drug discovery collaboration agreement with Reborna Biosciences Inc. to generate RNA-targeting novel small molecules in the field of the central nervous system.
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Nasal spray
Drug design, drug delivery & technologies

Intranasal bacterium for targeted brain delivery

Feb. 25, 2025
In a recent publication in Cell, researchers from the National University of Singapore and collaborators have proposed using commensal bacteria in the nasal cavity as a delivery vector for precision therapy targeting the OE and brain.
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D-rendered image showing atlas of human embryonic skeletal development
Drug design, drug delivery & technologies

More than 100M cells included in the human cell atlas

Nov. 26, 2024
By Mar de Miguel
An international consortium of thousands of scientists is creating the Human Cell Atlas, a three-dimensional map of all the cells in the body. The goal is to understand all the cells that make up human tissues, organs and systems, which will enable multiple medical applications. This collection of cell maps is openly available for navigation at single-cell resolution, identified through omics analyses that reveal the tridimensional distribution of each cell.
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Components of a radiopharmaceutical
KoNECT 2024

Panel discusses radiopharmaceuticals, oral small-molecule drugs for AD

Nov. 5, 2024
By Marian (YoonJee) Chu
A year out from Leqembi’s approval for Alzheimer’s disease (AD), ongoing research coupled with artificial intelligence is advancing both radiopharmaceuticals and small-molecule drugs for AD diagnostics and treatment, speakers at the 2024 KoNECT-MOHW-MFDS conference said.
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Illustration of proteins and year they were developed
Drug design, drug delivery & technologies

Chemistry Nobel awarded for 3D protein design, prediction work

Oct. 15, 2024
By Mar de Miguel
David Baker, Demis Hassabis and John Jumper share the 2024 Nobel Prize in Chemistry for their contributions to the science of protein structure. David Baker was awarded half the prize “for computational protein design,” according to the Royal Swedish Academy of Sciences. Hassabis and Jumper shared the other half “for protein structure prediction.”
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Drug design, drug delivery & technologies

Chemistry Nobel awarded for 3D protein design, prediction work

Oct. 9, 2024
By Mar de Miguel
David Baker, Demis Hassabis and John Jumper share the 2024 Nobel Prize in Chemistry for their contributions to the science of protein structure. David Baker was awarded half the prize “for computational protein design,” according to the Royal Swedish Academy of Sciences. Hassabis and Jumper shared the other half “for protein structure prediction.”
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Illustration of Toxoplasma gondii tachyzoites
Drug design, drug delivery & technologies

Parasite could deliver therapeutic proteins to the brain

Aug. 13, 2024
By Mar de Miguel
Infection or cure? Scientists from Tel Aviv University and the University of Glasgow genetically modified the Toxoplasma gondii to bring a protein inside neurons. The novelty of using a protozoan that can travel from the gut to parasitize the CNS contrasts with the possibility of causing a disease. The scientists are already working on how to avoid it.
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Bridge recombinase mechanism 3D illustration

New techniques open the way for large-scale programmable genome editing

July 2, 2024
By Mar de Miguel
New single-step genome editing techniques that enable the insertion, inversion or deletion of long DNA sequences at specified genome positions have been demonstrated in bacteria.
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Colorful illustration of the heart
Cardiovascular

Human iPSCs restore muscle, function in monkeys with heart failure

May 7, 2024
By Tamra Sami
Japanese researchers have transplanted human induced pluripotent stem cells (iPSCs) in a primate model of myocardial infarction and were able to restore heart muscle and function in monkeys. Developed by Tokyo-based Heartseed Inc., the grafted iPSCs consist of clusters of purified heart muscle cells (cardiomyocyte spheroids) that are injected into the myocardial layer of the heart. Published in Circulation on April 26, 2024, the study showed that the cardiomyocyte spheroids survived long term and showed improved contractile function with low occurrence of post-transplant arrhythmias.
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