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Home » Authors » Randy Osborne

Articles by Randy Osborne

Deal handshake with graphic overlay

Dealer’s choice: Further Seagen BD in cards as Merck on button, makes whopper bet

Sep. 14, 2020
By Randy Osborne
Though falling short of the outright takeover that some may have hoped for, Merck & Co. Inc.’s dual tie-ups with Seattle Genetics Inc. (Seagen) put the latter in solid position to shop for acquisitions of its own.
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Merck buys $1B stake in Seattle Genetics as part of ADC pact; Tukysa tie-up, too

Sep. 14, 2020
By Randy Osborne
Woman sleeping

Once upon a time: Avadel, Jazz sleep stories vie in narcolepsy’s new world

Sep. 11, 2020
By Randy Osborne
Investors clipped shares of Avadel Pharmaceuticals plc recently as anxieties rose over the application by Jazz Pharmaceuticals plc for a patent that relates to a once-nightly oxybate product that could threaten the prospects for Avadel’s FT-218.
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RNA illustration

A knight at the OPERA? Kraken the RNA code, Korro on (r)ADAR with $91.5M series A

Sep. 10, 2020
By Randy Osborne
Nessan Bermingham, Korro Bio Inc.’s co-founder and executive chair, told BioWorld that other groups are looking into adenosine deaminase acting on RNA (ADAR) – the body’s natural base editing system – but “we’re the first group, as far as I’m aware” to raise big money and bring together what could become the best technology for developing drugs based on an understanding of ADAR.
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Red blood cells

BETs favor Constellation phase III in MF despite cited Jakafi dosing hitch

Sep. 10, 2020
By Randy Osborne
As Constellation Pharmaceuticals Inc. gears up to start the pivotal phase III study of CPI-0610 in myelofibrosis (MF), Wall Street is mulling how likely are the stars to align for the Cambridge, Mass.-based company with its small-molecule inhibitor of bromodomain and extra-terminal (BET) proteins.
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Health professional pointing stethoscope at Clinical Trial words, icons

Background (therapy) check: Corbus looking into phase III stymie in SSc and ahead to DM, CF

Sep. 8, 2020
By Randy Osborne
Corbus Pharmaceuticals Holdings Inc.’s lenabasum having failed its phase III test in diffuse cutaneous systemic sclerosis (SSc), attention turned to prospects with the cannabinoid receptor type 2 agonist for other indications.
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Fallopian tubes, ovaries and uterus

Three-dimensional push with relugolix making Myovant’s appeal real

Sep. 4, 2020
By Randy Osborne
With the PDUFA date for relugolix against prostate cancer growing nearer and data in castration resistance-free patients closer still, Myovant Sciences GmbH aims to wring more from the oral, once-daily gonadotropin-releasing hormone receptor antagonist, studying it in uterine fibroids and endometriosis.
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Kidney disease illustration

Cliff notes: Akebia stock falls off as phase III synopsis shows vadadustat safety fail; burial plot premature?

Sep. 3, 2020
By Randy Osborne
Akebia Therapeutics Inc. CEO John Butler said “a clear path forward” exists for vadadustat in chronic kidney disease (CKD) despite negative phase III safety findings, and the company plans to file for approval as early as next year in the U.S. and Europe.
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News in kidney has ‘bean’ not so great lately; Akebia phase III to change -stat(us)?

Sep. 2, 2020
By Randy Osborne
As the world awaits more phase III data due any day from Akebia Therapeutics Inc. with vadadustat, its oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), in chronic kidney disease (CKD), the company is basking in the approval of the product in Japan as Vafseo as a once-daily treatment for CKD anemia.
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Palforzia capsules

As FDA crunch bars DBV, Nestle gobbles Aimmune for $2.6B

Aug. 31, 2020
By Randy Osborne
Less than a month after would-be competitor DBV Technologies SA suffered a regulatory setback with its peanut allergy patch candidate, Aimmune Therapeutics Inc. – which at the start of the year gained FDA clearance for Palforzia in the same space – is undergoing an all-cash takeover valued at $2.6 billion by Nestle SA unit Nestle Health Science SA.
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