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Home » Authors » Anette Breindl

Articles by Anette Breindl

CRISPR-edited kidney under microscope
Immune

Most-edited-ever donor genomes lead to 2-year survival in porcine-to-primate kidney transplants

Oct. 11, 2023
By Anette Breindl and Mar de Miguel
Scientists at Egenesis Inc. have transplanted kidneys from genome-edited pigs into cynomolgus monkeys that remained functional for long periods after transplantation. The monkeys, whose own kidneys were removed during the surgery, survived for a median of 176 days after receiving one pig kidney. Maximal survival was just over 2 years. The data were published today in Nature. Egenesis CEO Mike Curtis told reporters that the study has achieved the longest survival to date “using clinically translatable immunosuppression … longer survival has been achieved using really aggressive immunosuppression that really isn’t clinically translatable.”
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AI generated illustration of a brain on fire
Neurology/Psychiatric

ECNP 2023: Look for antibodies in idiopathic psychoses? First, maybe better tests

Oct. 10, 2023
By Anette Breindl
For individuals who develop an unexpected psychosis, there is something to be said for testing them for autoimmune antibodies. And something against. At the 36th Congress of the European College of Neuropsychopharmacology (ECNP) this week, the topic was worth a controversy session, where speakers presented the pros and cons of the approach. Currently used tests have a specificity of 99%. But as Ester Coutinho, consultant neurologist at the University of Coimbra, pointed out, the validity of diagnostic tests depends on the prevalence of the disorder one is looking for as well. Coutinho estimated that autoimmune psychoses account for 1% of psychoses overall.
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Woman  in military clothing talking with psychologist
Neurology/Psychiatric

ECNP 2023: Boosting fear unlearning is one avenue toward treating PTSD

Oct. 9, 2023
By Anette Breindl
For most psychiatric illnesses, the precipitating event is mysterious. Many conditions are thought to result from a mix of genetic risk and environmental factors, but the specific trigger remains unknown. In post-traumatic stress disorder (PTSD), the environmental trigger is usually clear. In many cases, it is all the affected individuals can think about. “Intrusive reliving” of the triggering situation is one of the core features of PTSD.
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Generative AI illustration depicting the structure of a granuloma caused by tuberculosis
Infection

To fight TB, understanding state transitions helps help cells make better choices

Oct. 3, 2023
By Anette Breindl
Tuberculosis (TB) is the second leading infectious disease killer. According to the World Health Organization, every year, more than 10 million people fall ill with TB, and 1.5 million people die from the disease. The thing is, though, that it could be worse. Not nearly everyone who is infected has TB disease. “Tuberculosis is a disease that targets a small number of infected people,” Igor Kramnik, of Boston University, told BioWorld.
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AI generated illustration of a brain on fire
Neurology/Psychiatric

Newco news: Arialys has autoimmune solution to psychosis problem

Sep. 27, 2023
By Anette Breindl
Arialys Therapeutics Inc. launched this month with $58 million in seed funding, an experimental compound it is developing for autoimmune encephalitis and autoimmune psychosis, and high aspirations for its field. “Yes, I want to treat these patients, I want these patients to have a better life. But I also want drug discovery and development folks to think differently about discovering new drugs for the CNS,” Jay Lichter told BioWorld.
Read More
Stem cell-derived vertebral bone with recruited breast cancer tumor cells
Musculoskeletal

The skeletal stem cell contains multitudes, with translational implications

Sep. 20, 2023
By Anette Breindl
Long bones, vertebrae and skull bones have distinct types of stem cells, and new insights into those stem cells could lead to new ways to treat both rare developmental disorders of skull formation and the all-too-common phenomenon of bone metastases. Scientifically, the work, which was published in two papers by Matthew Greenblatt and colleagues in Nature, adds to the increasing understanding of bone’s complexities. “Bone may serve as an endocrine organ that is secreting factors throughout the body,” Greenblatt said.
Read More
Illustration of Alzheimer’s in the brain.
Neurology/Psychiatric

Study identifies cause of death for Alzheimer’s neurons

Sep. 18, 2023
By Anette Breindl
By creating a new mouse model of Alzheimer’s disease that better recapitulated how the disease plays out in humans, investigators at KU Leuven have gained new insights into how amyloid plaques, tau tangles and neuronal death are related at the molecular level.
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High-density lipoprotein particles and red blood cells
Biomarkers

From membranes to metabolites, looking at lipids

Sep. 14, 2023
By Anette Breindl
Lipids are “very diverse, but also vastly understudied,” Anne Brunet told the audience at the recent meeting on Aging Research and Drug Discovery. Advances in the ability to predict protein structures have fueled a much better understanding of the human proteome and its estimated 20,000 members. The lipidome is much larger, numbering maybe 100,000 total. And what those lipids do remains much more fuzzy. “Very little is known about their function, and especially their function during aging,” Brunet said. Slowly, however, technological advances are enabling researchers to understand the roles of lipids as well.
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Cardiovascular

Neuronal, blood vessel miscommunication affects aging heart: study

Aug. 31, 2023
By Anette Breindl
Throughout the body, the vasculature and the nervous system are fellow travelers. Renaissance physician and anatomist Andreas Vesalius described their proximity on the macroanatomical level in the 16th century, and modern microscopic techniques have shown that it extends into the micrometer range – where there is a blood vessel, there is often a nerve nearby, and vice versa.
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DNA double helix with sand hour glass

Biomarker brainteaser: Aging? Or just changing?

Aug. 30, 2023
By Anette Breindl
“Change is the only constant” is an ageless truth. In the search for age-related biomarkers, it is also a prosaic confounding factor.

Age-related biomarkers will be critical for the development of antiaging therapeutics. “Nobody is planning to do a life span study in humans,” Eric Verdin told the audience at the 10th Conference on Aging Research and Drug Development in Copenhagen on Monday. “Hence the need for … surrogate markers.”
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