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Home » Authors » Anette Breindl

Articles by Anette Breindl

Antibiotic resistance map of U.S.

Climate crisis is chronicle of a death foretold

May 4, 2020
By Anette Breindl
The climate crisis in the time of COVID-19 illustrates the difference between the important and the urgent. There is, of course, no alternative to focusing on the current pandemic. But at the same time, the SARS-CoV-2 coronavirus has not changed the fact that the climate crisis is a coming wave whose health consequences will ultimately dwarf those of any single infectious agent.
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Structure of the engineered pre-F

Bench Press for May 1, 2020

May 1, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: Neutralizing RSV; Insulin cuts both ways in vasculature; Transcriptomic insights into Parkinson’s disease; Restoring synaptic transmission for rare neurodevelopmental disease; Polymerase k and drug resistance; Sphingolipids accumulate in neurodegeneration; How does innate immunity remember? Not via polycomb; Antibiotics affect oxycodone effects; Cabo as next annual shot?
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AACR 2020

Phosphatases are yin to kinases’ yang

May 1, 2020
By Anette Breindl
The activity of many proteins is controlled through phosphorylation by kinases and dephosphorylation by phosphatases. Overactive kinases are one of the major drivers of tumors and, as a result, kinase inhibitors are a mainstay of oncology drug development. But “activation of the brakes, the phosphatases, could be equally therapeutically viable for the treatment of a broad range of cancers” to kinase inhibition, Goutham Narla told the audience at the 2020 American Association for Cancer Research (AACR) meeting.
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BioWorld MedTech’s Diagnostics Extra for April 30, 2020

April 30, 2020
By Meg Bryant and Anette Breindl
Keeping you up to date on recent developments in diagnostics, including: Deep neural network for colorectal polyp classification; Biomarkers signal chemo-induced heart damage; AI helps gauge risk of severe COVID-19 infection; Platelets play role in Tylenol toxicity.
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Vero E6 cell infected with SARS-CoV-2
Thwarting the hijacker

In vitro study gives ‘blueprint’, drug leads for SARS-CoV-2

April 30, 2020
By Anette Breindl
A multi-institutional group led by the University of California at San Francisco’s Quantitative Biosciences Institute (QBI) has identified more than 200 host proteins that interacted with SARS-CoV-2 viral proteins during infection, creating “a blueprint of how SARS-CoV-2 hijacks human cells,” QBI Director Nevan Krogan told reporters. They then used that blueprint to identify 10 drugs, some FDA approved and some in clinical trials, that were able to inhibit viral growth in cell culture assays, marking them for further study as potential antivirals. The work also identified one compound, dextromethorphan, that appeared to facilitate viral growth.
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BioWorld MedTech’s Oncology Extra for April 28, 2020

April 28, 2020
By Mark McCarty and Anette Breindl
Keeping you up to date on recent developments in oncology, including: Small tumors and large motion effects dampen treatment effect in IMPT; Pancreatic cancer uses autophagy to hide from immune system; NRF2 wakes sleeping tumor cells; Cancer renders patients more susceptible to COVID-19.
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BioWorld MedTech’s Neurology Extra for April 24, 2020

April 24, 2020
By Andrea Applegate and Anette Breindl
Keeping you up to date on recent developments in neurology, including: Nanocarrier developed for drug delivery across the BBB; 3D face analysis could screen for sleep apnea; Long noncoding RNA has sex-specific role in depression; Noncoding TET2 variants affect neurodegeneration risk.
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Islet clusters

Bench Press for April 24, 2020

April 24, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: Edited stem cells reverse mouse diabetes; Noncoding TET2 variants affect neurodegeneration risk; Pancreatic cancer uses autophagy to hide from immune system; Heart failure hormone has role in sepsis; NRF2 wakes sleeping tumor cells; Oral drug can wake up telomerase; Cheating cell death improves infarct outcomes; Older siblings’ example turns stem cells into heart cells; Lung changes from PD drug hopeful are reversible; Platelets play role in Tylenol toxicity.
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BioWorld MedTech’s Diagnostics Extra for April 23, 2020

April 23, 2020
By Meg Bryant and Anette Breindl
Keeping you up to date on recent developments in diagnostics, including: Automated CT biomarkers predict future CV events; PCR heightens detection of scabies; High BMI linked to dementia via complement component.
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Marburg virus

In antibody ensemble, second fiddles help the neutralizing stars

April 23, 2020
By Anette Breindl
By analyzing the antibody response of a survivor of Marburg virus infection, researchers at the University of Texas Medical Branch and Vanderbilt University Medical Center have gained new insights into the function of non-neutralizing antibodies in fighting infections.
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