Keeping you up to date on recent developments in diagnostics, including: Tracking heart function with AI; Localizing arrhythmia; Wearables not yet ready for prime time; A20s inflammation-fighting properties decoded.
COVID-19 has disrupted science in the way it has disrupted everything else. In the short term, universities have largely closed shop as a way to maximize social distancing, and lots of science – or at least, lots of bench work – is not getting done.
Keeping you up to date on recent developments in oncology, including: How lung tumors seed to brain; UVA looks to genes to improve cancer outcomes; Study shows promise of immunotherapy against solid tumors.
As organisms adapt to their environment, adaptations that serve them in their current environment can become liabilities if that environment changes. The control of traits that are an asset in one situation and a liability by the same gene is called antagonistic pleiotropy. In the March 16, 2020, online issue of Nature Genetics, researchers reported a method to systematically identify mutations that conferred antagonistic pleiotropy – in the form of resistance to one drug, but heightened sensitivity to another – in acute myeloid leukemia (AML) cells.
BioWorld looks at translational medicine, including: How the eye cleans itself up; In blood stem cells, selection drives driver mutations early on; Dead cells do tell tales; Selective TGF-beta inhibition helps checkpoint blockade; How lung tumors seed to brain; Butyrate affects regulatory B cells, rheumatoid arthritis; Lamin A/C’s presence in nucleus, absence from membrane both problematic in progeria; Females, males have different metabolic response to intermittent fasting; Ditching PAMs expands CRISPR.
Keeping you up to date on recent developments in diagnostics, including: Improving TBI prognosis; Speeding detection of antibiotic resistant infections; Multistep method wrests causality from GWAs; In blood stem cells, selection drives driver mutations early on.
Keeping you up to date on recent developments in oncology, including: New study hints that 3D chromatin architecture a key in childhood leukemia; Recruiting NK cells to the antitumor battle; 3D printing meets the medical isotope business.
Keeping you up to date on recent developments in neurology, including: ‘Natural killer’ cells could halt PD progression; Neuroinflammation linked to several forms of dementia; GOF, LOF mutations take different paths to same result; Study links GABA, mitochondria, social defects.
BioWorld looks at translational medicine, including: Heparan sulfate DAMPens acetaminophen toxicity; Study links GABA, mitochondria, social defects; Recruiting NK cells to the antitumor battle; Potassium channel blocker improves motor learning in fetal alcohol syndrome; A20s inflammation-fighting properties decoded; Brown fat activity without fat browning; Agonists selectively wake up melatonin receptor subtypes; Multistep method wrests causality from GWAS; BET on BD1 for cancer, BD2 for inflammation.
