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Home » Authors » Anette Breindl

Articles by Anette Breindl

Doctor pointing at liver
AASLD 2019

With NASH drugs on the cusp of arrival, noninvasive diagnostics are 'second pillar of need'

Nov. 12, 2019
By Anette Breindl

BOSTON – For diagnosing nonalcoholic steatohepatitis (NASH), liver biopsy is "the reference standard," Dean Hum, president of Genfit Corp., told BioWorld. "I'm not going to call it the gold standard." Some of the reasons for denying biopsies a gold sticker are obvious. Biopsies are invasive, which makes them risky, expensive and loathed by patients and doctors alike. "In the real world, doctors don't always do biopsies – many say they very rarely do biopsies unless other data points in several directions and they need that for clarity," Gail Cawkwell told BioWorld.


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PROTAC attack joins molecular glue for protein degradation

Nov. 11, 2019
By Anette Breindl
BOSTON – At the AACR-NCI-EORTC Molecular Targets meeting in October, speakers in the second plenary session gave examples both of how far protein degradation has come as a pharmacological approach, and how far it could still go.
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BioWorld MedTech's Neurology Extra

Nov. 11, 2019
By Liz Hollis and Anette Breindl
Keeping you up to date on recent developments in neurology.
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BioWorld MedTech's Oncology Extra

Nov. 6, 2019
By Mark McCarty and Anette Breindl
Keeping you up to date on recent developments in oncology.
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Bench Press for Nov. 4, 2019

Nov. 4, 2019
By Anette Breindl
BioWorld looks at translational medicine.
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BioWorld MedTech's Neurology Extra

Nov. 4, 2019
By Liz Hollis and Anette Breindl
Keeping you up to date on recent developments in neurology.
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KRAS protein
AACR-NCI-EORTC 2019

At Molecular Targets Meeting, a bonanza of ways to thwart once-undruggable KRAS

Oct. 30, 2019
By Anette Breindl
BOSTON, Mass. – KRAS used to be the poster child for undruggability. No more. Amgen Inc. and Mirati Therapeutics Inc. are in the clinic with KRAS inhibitors. Boehringer Ingelheim GmbH is planning to join them by the end of the year. And multiple other companies are moving programs forward.
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BioWorld MedTech's Oncology Extra

Oct. 30, 2019
By Mark McCarty and Anette Breindl
Keeping you up to date on recent developments in oncology.
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Molecular Targets Meeting 2019

Bispecific matchmakers can improve antibodies, CARs

Oct. 29, 2019
By Anette Breindl
BOSTON – Researchers from Memorial Sloan-Kettering Cancer Center presented encouraging, though very early, data on Merus NV's bispecific antibody MCLA-128 for the treatment of patients with NRG-1 gene fusions at the AACR-NCI-EORTC Molecular Targets meeting on Sunday.
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Less is more

Rightsizing brain activity increases lifespan, but REST is not all good

Oct. 28, 2019
By Anette Breindl
Two very different roles were reported for the protein REST last week. In adults, REST activation appeared to extend lifespan by reducing overall brain activity. Principal investigator Bruce Yankner, professor of genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biology of Aging, told BioWorld MedTech that in postmortem brain samples of individuals who had had no cognitive impairments at the time of their death, his team found "a correlation between down-regulation of excitation and extended longevity."
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