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Home » Authors » Anette Breindl

Articles by Anette Breindl

Bench Press: BioWorld looks at translational medicine

Sep. 9, 2019
By Anette Breindl
Researchers at the University of California at San Diego have used a strategy of "rock-paper-scissors" to engineer more durable synthetic circuits into bacteria. 
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Entyvio for HIV control flops in clinical trial, replication studies

Sep. 6, 2019
By Anette Breindl
Three separate research teams have failed to replicate a 2016 primate study showing that treatment with a primate version of monoclonal antibody Entyvio (vedolizumab, Takeda Pharmaceutical Co. Ltd.), led to prolonged suppression of viremia in SHIV-infected monkeys. 
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Bench Press: BioWorld looks at translational medicine

Sep. 3, 2019
By Anette Breindl
Researchers at the Christian Albrechts University of Kiel and the MRC London Institute of Medical Science have developed a way to screen four-way interactions between genetically simple hosts, their microbiome, nutrients and drugs. 
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Autologous iPSCs can lead to immune response

Aug. 29, 2019
By Anette Breindl
From the research point of view, making induced pluripotent stem cells (iPSCs) is perhaps not exactly easy, but routine rather than a heroic effort.
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AI's superpowers lie in questions, not answers

Aug. 26, 2019
By Anette Breindl

AI's superpowers lie in questions, not answers

Aug. 26, 2019
By Anette Breindl
The hype surrounding artificial intelligence (AI) can make it sound like the technology has all the answers. But from a scientific perspective, one of the technology's biggest strengths is that it can ask better questions.
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Bench Press: BioWorld looks at translational medicine

Aug. 26, 2019
By Anette Breindl
TRK inhibitors, like essentially all targeted therapies, are vulnerable to resistance mutations, and several resistance mutations to Vitrakvi and the recently approved Rozlytrek have been described. The most common form of resistance to targeted therapies, and the only mechanisms that have been described for TRK inhibitors to date, are due to mutations in the target itself. Now, researchers at Memorial Sloan-Kettering Cancer Center have described resistance to TRK inhibitors that occurred due to activation of the MAP kinase (MAPK) pathway. 
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Bench Press: BioWorld looks at translational medicine

Aug. 19, 2019
By Anette Breindl
Investigators at Stanford University have created a panel of isogenic iPSC-derived neurons with various mutations of amyloid precursor protein (APP) and presenilin (PSEN), and used it to demonstrate that accumulation of APP beta C-terminal fragments (beta-CTFs), but not of amyloid beta, correlated with endosomal dysfunction and could be improved by inhibiting beta-secretase (BACE-1). Genetic evidence clearly implicates APP misprocessing in Alzheimer's disease (AD), and amyloid beta plaques are the disease's major anatomical calling card, which has led to a focus on therapeutic targeting of the latter. However, that therapeutic targeting has failed multiple times, and the evidence linking amyloid beta to AD is weaker than that for APP. Recently, endosomal dysfunction has been proposed as "another plausible underlying pathological mechanism," leading the authors to investigate the causes of endosomal dysfunction in their cell lines. They showed that endosomal dysfunction, which leads to deficits in intracellular transport, was correlated with changes in beta-CTF but not amyloid beta.
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Bench Press: BioWorld looks at translational medicine

Aug. 12, 2019
By Anette Breindl
The blood-brain barrier prevents many drugs from entering the brain. Unfortunately, the same cannot be said for tumor cells. The brain is one of the most frequent locations for cancer metastases, which are then extremely challenging to treat. Now, researchers at the University of California at Los Angeles have developed an encapsulation technique that allowed the delivery of the monoclonal antibody Rituxan (rituximab) to brain metastases of a mouse xenograft model of non-Hodgkin lymphoma. 
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Luca Biologics aims for Goldilocks approach to microbiome medicine

Aug. 7, 2019
By Anette Breindl
The microbiome has broad and deep effects on pretty much all aspects of health. So broad and so deep, in fact, that how to best translate those effects into medical interventions remains an open question.
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