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Home » Authors » Brian Orelli

Articles by Brian Orelli

R&R's DirectMarkets Links Companies with Investors

Feb. 13, 2012
By Brian Orelli
Since the beginning of the biotech industry, finding capital has always been a major factor in the success of a company. Without cash, it's hard to develop drugs.
Read More

Regulatory and Commercial Hurdles Test Diabetes Drugs

Feb. 6, 2012
By Brian Orelli
Amylin Pharmaceuticals Inc.'s FDA approval of Bydureon (exenatide extended-release) late last month was a long time coming. The company first applied for approval in 2009, requiring three attempts before the FDA finally signed off.
Read More

VCs Eye Bargain IPOs as Option for New Investment

Jan. 30, 2012
By Brian Orelli
It's become routine for current venture capital (VC) investors to buy additional shares when a biotech goes public. Initial public offerings (IPO) are no longer an exit strategy, but a further round of funding to get the insiders to the end game. The extra cash from insiders reduces the amount that needs to be raised, helps support the price and, with recent IPO pricing difficulty, has been a way for insiders to reduce their cost base.
Read More

Xoma and Dara Jump Into Commercial Game Early

Jan. 23, 2012
By Brian Orelli
Biotechs acquiring rights to commercial drugs before gaining marketing approval of their own lead candidate is nothing new to the industry; an experienced sales force can be worth its weight in gold.
Read More

Record Year for Royalty Deals Builds Optimism for 2012

Jan. 17, 2012
By Brian Orelli
Not everyone is upset about the turmoil in the equity markets. Last year was a record year for the sale of royalty streams and other structured product deals, in large part because of the lack of other options for biotechs.
Read More

Reata's $400M from Abbott Shows Up-Front Trend in 2011

Jan. 9, 2012
By Brian Orelli
Last month, Reata Pharmaceuticals Inc. snagged $400 million from Abbott for half of its second-generation antioxidant inflammation modulator (AIM) portfolio, bucking a trend over the last few years of putting the risk on the innovator through milestone payments. (See BioWorld Today, Dec. 13, 2011.)
Read More

Busy Schizophrenia Market, But Alkermes Presses On

Jan. 3, 2012
By Brian Orelli
In spite of a market with numerous options for patients, Alkermes plc is pressing on with ALKS 9070, its long-lasting schizophrenia treatment. Last month the company started a Phase III trial testing the once-monthly drug in patients experiencing acute exacerbation of schizophrenia. (See BioWorld Today, Dec. 20, 2011.)
Read More

Grappling with Drug-Induced Liver Toxicity - Bane of Biotech

Dec. 27, 2011
By Brian Orelli
Despite biopharmas' best efforts, around 40 percent of cases of drug-induced liver injury aren't discovered in preclinical studies. That stands in stark contrast to toxicity in hematological, gastrointestinal and cardiovascular systems, where only 10 percent to 20 percent of problems aren't caught in preclinical studies.
Read More

Some Drugs Sell Themselves; Others Don't, Spectrum Finds

Dec. 19, 2011
By Brian Orelli
Despite a better efficacy and safety profile than Rituxan (rituximab, Roche AG and Biogen Idec Inc.), Zevalin ([90Y]-ibritumomab tiuxetan), the radioactive form of Rituxan, has never been a big seller.
Read More

Biotech Short Selling Up Slightly, But Not All Bad

Dec. 12, 2011
By Brian Orelli
Short sellers are generally considered blasphemers by biotech firms. And for good reason; short sellers borrow shares in order to sell them, which puts negative pressure on the stock. The only way shorts make money is if shares go down.
Read More
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