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Home » Authors » Brian Orelli

Articles by Brian Orelli

Visterra's Antibody Generates Broad Spectrum Antiviral Therapy

Sep. 24, 2012
By Brian Orelli
Visterra Inc. made a splash at this year's Interscience Conference on Antimicrobial Agents and Chemotherapy. The company has developed an antibody, VIS410, that neutralizes a broad spectrum of influenza A strains in a preclinical animal model. (See BioWorld Today, Sept. 12, 2012.)
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New Tech, New JV: MedImmune Sees Potential Growth for Both

Sep. 17, 2012
By Brian Orelli
MedImmune is taking its new YTE technology to China. Last week, the biologics arm of AstraZeneca plc established a joint venture with WuXi AppTec to develop its anti-inflammatory drug MEDI5117 for the China market.
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Idenix Tries to Convince FDA Not All Nucs Are Created Equal

Sep. 10, 2012
By Brian Orelli
The demise of Bristol-Myers Squibb Co.'s hepatitis C drug BMS-986094, which BMS discontinued development of after patients in its Phase IIb study experienced heart and kidney toxicity, stretched further than just the big pharma. The FDA put a partial clinical hold on Idenix Pharmaceuticals Inc.'s related nuc IDX184 and then slapped a hold on its next-generation nuc, IDX19368, as well.
Read More

For Targeted Radiotherapy, Actinium Hopes Less Is More

Sep. 4, 2012
By Brian Orelli
Linking a radioactive molecule to an antibody to pinpoint the radiation at the tumor is nothing new; targeted radiotherapy has been around for years.
Read More

DNA Patents: Isolation and Use Trump Analysis, Comparisons

Aug. 27, 2012
By Brian Orelli
Earlier this month, the U.S. Court of Appeals for the Federal Circuit upheld the validity of Myriad Genetics Inc.'s patent claims based on the composition of isolated DNA. (See BioWorld Today, Aug 17, 2012.)
Read More

Arrowhead Buys Alvos, Signs Up (First) Partner Four Months Later

Aug. 20, 2012
By Brian Orelli
In April, Arrowhead Research Corp. bought Alvos Therapeutics Inc. in an all-stock deal valued at about $2.1 million plus additional stock worth up to $23.5 million based on the achievement of clinical and regulatory milestones.
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Vivus Prepares to Roll Out Qsymia, Grow Obesity Market

Aug. 13, 2012
By Brian Orelli
After gaining FDA approval for its obesity drug Qsymia (phentermine/topiramate) last month, Vivus Inc. went to work preparing for a fourth-quarter launch of the drug. (See BioWorld Today July 19, 2012.)
Read More

Amarin Gains Approval, Next Step: Holding Off Generics

Aug. 6, 2012
By Brian Orelli
Amarin Corp. plc got a green light from the FDA to market its triglyceride-lowering drug Vascepa (icosapent ethyl) last month. Now the biotech needs to give a red light to potential generic competitors. 
Read More

Biotechs Set Their Sights on Dry AMD Treatments

July 30, 2012
By Brian Orelli
Regeneron Pharmaceuticals Inc. stormed onto the wet age-related macular degeneration (AMD) market with second quarter sales of Eylea (aflibercept injection) increasing 57 percent compared to their first quarter. The drug competes with Roche AG's Lucentis (ranibizumab) and off-label use from Avastin (bevacizumab).
Read More

Biotechs Set Their Sights on Dry AMD Treatments

July 30, 2012
By Brian Orelli
Regeneron Pharmaceuticals Inc. stormed onto the wet age-related macular degeneration (AMD) market with second quarter sales of Eylea (aflibercept injection) increasing 57 percent compared to their first quarter. The drug competes with Roche AG's Lucentis (ranibizumab) and off-label use from Avastin (bevacizumab).
Read More
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