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Home » Authors » Mar de Miguel

Articles by Mar de Miguel

CAR T cell attacking cancer cells
Cancer

Removing CD5 'brake' on CAR T cells increases antitumor efficacy

Aug. 2, 2024
By Mar de Miguel
To be successful, CAR T-cells need a balance between being effective and overkill. Researchers from the University of Pennsylvania and Vittoria Biotherapeutics Inc. have eliminated the CD5 signaling pathway of their CAR Ts to prevent the immunosuppressive brake effect. In return, this improved their proliferation and antitumor activity in T cell lymphomas.
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Dr. Widjaja viewing experimental data on the computer
Aging

Stop interleukin-11 to age better and live longer

July 26, 2024
By Mar de Miguel
Increased life expectancy also comes with age-related diseases. But what causes one to age? Although there is no single answer, scientists at Duke-National University of Singapore have shown in mice that interleukin-11 (IL-11) promoted aging. Blocking it improved health and lifespan.
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Liver disease
Cancer

As target organ, liver can influence which metastases take

July 26, 2024
By Mar de Miguel
Not all cancer cells that detach from the primary tumor and embark on a journey to another organ colonize it. To establish themselves, cells need specific conditions. Scientists at the Federal Institute of Technology Zurich (ETH Zurich) explored this hypothesis in the liver and identified a protein involved in metastatic transformation. Blocking it prevented liver metastasis. Their findings may have applications in other organs and various types of cancers.
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Dr. Widjaja viewing experimental data on the computer
Aging

Stop interleukin-11 to age better and live longer

July 24, 2024
By Mar de Miguel
Increased life expectancy also comes with age-related diseases. But what causes one to age? Although there is no single answer, scientists at Duke-National University of Singapore (NUS) have shown in mice that interleukin-11 (IL-11) promoted aging. Blocking it improved health and lifespan.
Read More
Illustration of a cluster of ovarian cancer cells
Cancer

Cancer cells adapt to resist therapy step by step

July 23, 2024
By Mar de Miguel
The adaptation of cancer cells to therapies limits the effectiveness of treatments. However, understanding the mechanisms they use to do it could help reverse them or be used to design more powerful drugs. Scientists at New York University (NYU) have studied the transitions causing resistance and have observed how it develops through a gradual process they have called the “resistance continuum.”
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Fruit fly muscles showing how well mitochondria produce energy
Infection

Infection and brain neuroinflammation weaken muscles

July 19, 2024
By Mar de Miguel
Muscle fatigue associated with brain inflammation could be prevented by modulating certain cytokines. Researchers at Washington University in St. Louis (WUSTL) have studied inflammation in the CNS in infection models of Escherichia coli, SARS-CoV-2 and amyloid-β toxicity, unveiling its impact on motor function, the role of IL-6 in this process and how to mitigate it in chronic disease.
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Illustration demonstrating parts of the ear

A gene therapy could restore hearing in adults

July 12, 2024
By Mar de Miguel
Patients with congenital hearing loss could benefit from a gene therapy currently in development. Although there are approaches that could reverse the process in children and young people before it becomes severe, so far, adults do not have any treatment that prevents the progressive deterioration of auditory sensory cells caused by this disease.
Read More
Illustration demonstrating parts of the ear
Drug design, drug delivery & technologies

A gene therapy could restore hearing in adults

July 11, 2024
By Mar de Miguel
Patients with congenital hearing loss could benefit from a gene therapy currently in development. Although there are approaches that could reverse the process in children and young people before it becomes severe, so far, adults do not have any treatment that prevents the progressive deterioration of auditory sensory cells caused by this disease.
Read More
Illustration of a helper t cell in the bloodstream
Immune

Finely slicing T cells yields rare, disease-associated subtypes

July 9, 2024
By Mar de Miguel
A new methodology based on the regulation of genetic enhancers has made it possible to develop a cellular map that reveals new types of helper T cells related to immunological disorders that could be explored for the development of new therapies. “I am very interested in the function of rare T cells, and I am trying to analyze their function by eliminating certain rare T cells with antibodies with ADCC [antibody-dependent cell-mediated cytotoxicity] activity or by disrupting genes that characterize rare T cells in animal models,” senior author Yasuhiro Murakawa told BioWorld.
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B-cell releasing antibodies

Engineered plasma cells produce effective bispecific antibodies against leukemia

July 5, 2024
By Mar de Miguel
Scientists at the University of Washington have engineered human plasma B cells modified to express long-lasting bispecific antibodies that could be used to treat leukemia without requiring continuous dosing.
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