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Home » Keywords » transplant rejection

Items Tagged with 'transplant rejection'

ARTICLES

Cytotoxic T cell illustration
Immune

Synthetic checkpoint engagers could prevent transplant rejection

Nov. 6, 2023
By Mar de Miguel
Scientists at the University of California San Francisco (UCSF) have designed a group of synthetic molecules that could prevent the rejection of allogeneic cell transplants. Their strategy consisted of activating the immune checkpoints of different populations of immune cells from the cell surface, but avoiding the cytotoxicity of natural killer (NK) cells and macrophages that would destroy the transplanted cells.
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Doctor with illustration of kidneys
Nephrology

Chronic transplant rejection requires antigen and IL-15

April 24, 2023
By W. Todd Penberthy
The limited state of current clinical transplantation science was recently the subject of an opinion piece from an individual that received her first heart transplant at just 25 years of age only to soon succumb at the age of 60 to one of the many risky outcomes expected for anyone taking standard requisite immunosuppression regimens used for any transplantation, in her case terminal cancer.
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Immune

Genetically engineered β cells evade autoimmunity in type 1 diabetes model

April 19, 2023
By Subhasree Nag
Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the person’s immune system destroys its own pancreatic islet cells that leads to complete loss of insulin production. Allogeneic pancreatic islet cell transplantation has been shown to replenish the vanished β-cell population and provide glycemic control, restoration of hypoglycemia awareness, and protection from severe hypoglycemic events. However, with allogeneic transplantation, there is a need for life-long immunosuppression to protect the islet grafts from allo- and autoimmunity.
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Red blood cells, DNA

Catalog of protein isoforms in blood cells can predict organ rejection

Feb. 2, 2022
By Subhasree Nag
Researchers have discovered a blood signature of protein isoforms that could potentially predict which patients may reject a new organ transplant, helping inform therapeutic decisions. The findings of this study are reported online in the January 27th edition of Science.
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Lungs wireframe illustration

Natera launches Prospera Lung transplant assessment test

Oct. 19, 2021
By Annette Boyle
Natera Inc. added its Prospera assessment for lung transplant patients to its portfolio, joining the company’s tests for rejection of kidney and heart transplants. The test uses donor-derived cell-free DNA (dd-cfDNA) to detect acute rejection as well as chronic rejection and infection in stable patients. Results of the VALID study presented at CHEST 2021 demonstrated that the Prospera Lung test had a negative predictive value of 97.33%, sensitivity of 89.06% and area under the curve of 0.91.
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Kidneys

Efficacy signal puts Tolerogenixx immune tolerance cell therapy on track for phase IIb

May 11, 2020
By Cormac Sheridan
DUBLIN – Tolerogenixx GmbH is on track to move its cell-based immune tolerance induction therapy for kidney transplant recipients into a 200-patient phase IIb trial, following the publication of promising data from a phase Ib trial, in 10 patients, in which all participants had a successful transplant at one-year follow-up.
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Two-year data buoy Hansa’s imlifidase MAA as CHMP decision looms

March 9, 2020
By Cormac Sheridan
DUBLIN – Hansa Biopharma AB is nearing a key milestone in its evolution, as a regulatory decision on its first marketing authorization application (MAA) looms. The EMA’s Committee for Medicinal Products for Human Use (CHMP) is expected to deliver an opinion during the second quarter on its application for imlifidase in supporting kidney transplants in sensitized patients.
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