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Home » Keywords » malaria

Items Tagged with 'malaria'

ARTICLES

Infection

Latvian Institute of Organic Synthesis describes new PfSUB1 inhibitors for malaria

July 9, 2025
Latvian Institute of Organic Synthesis has identified subtilisin-like protease 1 (PfSUB1) (Plasmodium falciparum) inhibitors reported to be useful for the treatment of malaria.
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Illustration of blood cells, Plasmodium causing malaria illness
Infection

Two cores better than one: combining carboline and triazole into small molecules against malaria

May 8, 2025
No Comments
Malaria continues to exact heavy financial and socioeconomic burdens in several parts of the world, with 249 million cases and more than 630,000 deaths reported in 2022. Two-thirds of malaria-related deaths occur among children younger than 5 years.
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Infection

AMA1-targeting antibodies provide multi-strain malaria protection

March 26, 2025
Writing in Cell Reports, researchers from the National Institute of Allergy and Infectious Diseases (NIAID) and collaborators have presented a multifaceted analysis and structure-function study of a panel of human monoclonal antibodies (hmAbs) targeting AMA1 elicited by natural Plasmodium falciparum infection in a malaria-endemic region in Mali.
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3D illustration of blood cells, plasmodium causing malaria illness
Infection

Plasmodium essential gene map gives malaria pharmacologic clues

Feb. 13, 2025
By Mar de Miguel
Two simultaneous but independent studies published in Science identified, by introducing mutants into its genome, the essential and nonessential genes of Plasmodium knowlesi, one of the malaria parasites related to the dreaded Plasmodium vivax. Their results could help in the development and prioritization of antimalarial strategies.
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Illustration of blood cells, Plasmodium causing malaria illness
Infection

TKK-130 is novel antiplasmodial agent

Jan. 24, 2025
Researchers from Heinrich-Heine-Universität Düsseldorf (HHUD) and affiliated organizations presented the discovery of novel antimalarial agents.
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Electron micrograph of red blood cell infected with Plasmodium falciparum surrounded by knobless uninfected blood cells.
Infection

Antigen-agnostic screening unveils new protective antibodies targeting a hidden malaria epitope

Jan. 20, 2025
Malaria remains a significant global health challenge, causing over 600,000 deaths annually despite existing prevention and treatment measures. Current vaccines and monoclonal antibodies (mAbs) against Plasmodium falciparum, such as RTS,S/AS01 and R21, primarily target the central repeat region of the circumsporozoite protein (CSP) but have shown limited efficacy in completely preventing infection.
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Infection

US researchers patent new compounds for malaria

Jan. 14, 2025
Researchers from Northeastern University and the University of Georgia have synthesized new tetrahydroacridinone analogues.
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Infection

MED-6189 is new pan-antimalarial agent

Oct. 31, 2024
Malaria is caused by Plasmodium species that infect hundreds of millions of people annually. Among the plasmodia, Plasmodium falciparum is considered the most dangerous due to frequent severe clinical complications and high mortality rates. Researchers from the University of California at Riverside described the discovery and mechanism of action of MED-6189, a kalihinol analog effective against drug-sensitive and drug-resistant P. falciparum strains in vitro and in vivo.
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Mosquito

Noul’s Milab offers accurate automated malaria diagnosis

Sep. 24, 2024
By Annette Boyle
Noul Co. Ltd.’s Micro-Intelligent Laboratory, an artificial intelligence-powered diagnostic system, demonstrated superiority over microscopic diagnosis for malaria in a study presented at the 2024 International Congress for Tropical Medicine and Malaria.
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Red blood cell infected with malaria parasites
Infection

Novartis synthesizes fast-acting intravenous agents for malaria

Sep. 18, 2024
The increasing resistance to intravenous artemisinin therapy for malaria highlights the urgent need for new treatments that offer better patient compliance and a single-dose cure to address this global health threat. Novartis AG recently presented the discovery, development and evaluation of aminoisoquinolines as fast-acting intravenous therapeutic agents for severe malaria treatment.
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