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Fri, May 23, 2025

Substance use and poisoning

Home » Topics » Disease categories and therapies » Substance use and poisoning
  • Nih nia synapse illustration
    May 21, 2025

    TAAR1 agonists reduce alcohol drinking and differentially modulate dopamine signaling in mouse model

    Currently available therapeutic strategies for alcohol use disorder (AUD) have limited efficacy, with many patients not responding to treatment. The dopaminergic system, involved in motivation and the reinforcing effects of drugs, has been proposed as an interesting target in AUD. 

  • Synapse neuronal connection nerve cell
    May 12, 2025

    Indivior advances GABA-B PAM program for substance use disorders through IND-enabling studies

    Indivior plc has successfully advanced its GABA-B positive allosteric modulator (PAM) program for substance use disorders through IND-enabling studies with the completion of the last preclinical safety and toxicity studies.
  • Fear depression mental health
    April 28, 2025
    By Mar de Miguel

    Psychedelics modulate neuroimmune interactions that control fear

    Research of the neuroimmune mechanisms involved in stress-related fear revealed how astrocytes interact with neurons in the amygdala. The study, led by Harvard scientists, also unveiled that this interaction recruited monocytes to the meninges during chronic stress and showed how psychedelic compounds reversed monocyte accumulation in the meninges and reduced fear behavior.
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