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Home » amyotrophic lateral sclerosis

Articles Tagged with ''amyotrophic lateral sclerosis''

Brain as light bulb filament
Neurology/Psychiatric

Oryzon Genomics awarded grant to support preclinical development of ORY-4001 in ALS

Dec. 5, 2023
Oryzon Genomics SA has been awarded a $498,690 grant by the ALS Association to support the regulatory preclinical development of ORY-4001, a highly selective histone deacetylase 6 (HDAC6) inhibitor, for amyotrophic lateral sclerosis (ALS).
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An illustration of the connections between muscle fibers and a motor neuron.
Neurology/Psychiatric

Stathmin-2 is new player in the ALS gene-verse

Dec. 5, 2023
By Subhasree Nag
A multi-institutional research team has suggested that aberrant TDP-43 processing of the pre-mRNA of a microtubule-associated protein, stathmin-2 (STMN2), may be the primary contributor to amyotrophic lateral sclerosis (ALS).
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Cumin on strong in neuro, Merck nabs Caraway via $610M deal

Nov. 21, 2023
By Randy Osborne
Merck & Co. Inc. continued to broaden its reach in neurodegenerative diseases by paying, through a subsidiary, as much as $610 million to take over preclinical-stage Caraway Therapeutics Inc. The deal involves an undisclosed up-front payment along with contingent milestone rewards.
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Neurology/Psychiatric

BROX is potential therapeutic target for ALS treatment

Nov. 21, 2023
Amyotrophic lateral sclerosis (ALS) is a disorder that leads to progressive muscle weakness and loss of muscle control due to affectation of the motor neurons. Increasing evidence points to defects in the nuclear envelope, which leads to disease progression.
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Neurology/Psychiatric

Fundamental Pharma discovers new TRPM4/NMDA interaction inhibitors for ALS

Nov. 16, 2023
Fundamental Pharma GmbH has described TRPM4/NMDA interaction inhibitors reported to be useful for the treatment of amyotrophic lateral sclerosis (ALS).
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Antibodies
Neurology/Psychiatric

Vectory Therapeutics closes series A financing to advance vectorized antibody into clinic

Nov. 14, 2023
Vectory Therapeutics BV has closed a €129 million ($138 million) series A financing to advance its vectorized antibody programs in neurodegenerative diseases.
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Neurons
Neurology/Psychiatric

Pasithea selects lead therapeutic candidate in ALS

Nov. 10, 2023
Pasithea Therapeutics Corp. has selected a lead therapeutic candidate for its PAS-003 program, a proprietary humanized monoclonal antibody that targets α5β1 integrin, a protein overexpressed in both humans and mice with amyotrophic lateral sclerosis (ALS).
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Neurology/Psychiatric

Gene editing approaches for the treatment of Huntington’s disease and ALS by Huidagene Therapeutics

Oct. 26, 2023
Huntington’s disease (HD) is caused by the CAG trinucleotide repeat expansion in exon 1 of the huntingtin (HTT) gene, leading to polyglutamine-expanded stretch of mutant huntingtin (mHTT) protein. Previous research has demonstrated that knockdown of HTT could represent an effective strategy for the inhibition of the formation of mHTT protein, and a recent study conducted by researchers from Huidagene Therapeutics Co. Ltd. aimed to assess the potential of high-fidelity Cas12Max (hfCas12Max)-based gene editing therapy as a novel treatment for HD.
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EMA logo on mobile screen, vials, syringes

Still a no for Amylyx’s ALS drug Albrioza as European regulator upholds negative vote

Oct. 16, 2023
By Caroline Richards
The EMA is standing firm on its refusal to recommend approval of the amyotrophic lateral sclerosis (ALS) treatment Albrioza in Europe after re-examining Amylyx Pharmaceuticals Inc.’s marketing authorization application and remaining unconvinced that the main study demonstrated the drug effectively slows disease progression.
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Stem-cells2.png

Adcom leaves Brainstorm looking at options

Sep. 28, 2023
By Mari Serebrov
Brainstorm Cell Therapeutics Inc. said it’s exploring all its options in the wake of a Sept. 27 U.S. FDA advisory committee vote, in which the committee overwhelmingly disagreed with the company that the data it presented supported the effectiveness of Nurown (debamestrocel) for the treatment of mild to moderate amyotrophic lateral sclerosis.
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