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Home » depression

Articles Tagged with ''depression''

Neurology/psychiatric

Sensorium Therapeutics describes new SERT and PDE4 inhibitors

June 5, 2024
Sensorium Therapeutics Inc. has identified alkylated derivatives of mesembrine or mesembrenone acting as serotonin transporter (SERT) and/or phosphodiesterase PDE4 inhibitors reported to be useful for the treatment of anxiety, depression and stress disorders.
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Two silhouettes with tangle, gear, spiral

Dissecting post-traumatic stress disorder and depression

May 31, 2024
By Mar de Miguel
Scientists from the PsychENCODE Consortium have analyzed the brain transcriptome in a coordinated series of studies to map all the cell types, genes, epigenetic factors, and molecular pathways involved in different psychiatric disorders. After a first set of projects based on bulk analysis, the second phase of this project included 14 simultaneous publications that revealed the cellular atlas of post-traumatic stress disorder and major depressive disorder, among others.
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AI generated illustration of a brain on fire
Neurology/psychiatric

Kapoose announces lead compounds in neurodegeneration, mental health

May 31, 2024
Kapoose Creek Bio Corp. has announced the identification and advancement of two lead compounds with potential in neurology, specifically for indications in neurodegeneration and mental health. The compounds, KCB-100 and KCB-200, have shown potent neuroplastic and neuroprotective activity in gold-standard tests of primary neurons.
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Art concept for endocannabinoids
Neurology/psychiatric

Tetra Pharm Technologies and Kvanctify collaborate to advance drug candidates targeting endocannabinoid system

May 30, 2024
Tetra Pharm Technologies ApS and Kvanctify ApS have entered into a strategic partnership to accelerate the identification and development of novel drug candidates targeting the endocannabinoid system.
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Two silhouettes with tangle, gear, spiral
Neurology/psychiatric

Dissecting post-traumatic stress disorder and depression

May 28, 2024
By Mar de Miguel
Scientists from the PsychENCODE Consortium have analyzed the brain transcriptome in a coordinated series of studies to map all the cell types, genes, epigenetic factors, and molecular pathways involved in different psychiatric disorders. After a first set of projects based on bulk analysis, the second phase of this project included 14 simultaneous publications that revealed the cellular atlas of post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), among others.
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Justin Hanka, CEO, Mindbio
Newco news

Mindbio explores psychedelic potential of LSD for depression, PMS

May 7, 2024
By Tamra Sami
The use of psychedelics is seeing impressive results in treating psychiatric disorders like treatment-resistant depression and post-traumatic stress disorder, and Mindbio Therapeutics Ltd. is expanding the field to include microdoses of lysergic acid diethylamide (LSD) to treat depression and premenstrual syndrome.
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Neurology/psychiatric

New KCNQ2/3 activators reported in Hansoh patent

April 25, 2024
Jiangsu Hansoh Pharmaceutical Group Co. Ltd. and Shanghai Hansoh Biomedical Co. Ltd. have described potassium voltage-gated channel subfamily KQT member 2/3 (KCNQ2/3) activators potentially useful for the treatment of epilepsy and depression.
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Gene drug interaction

Myriad’s test reduces gene-drug interactions, hospitalizations nearly 40%

April 11, 2024
By Annette Boyle
Finding an effective medication for patients with major depressive disorder is notoriously difficult, with 70% of patients failing to respond to the first drug prescribed and 30% not responding to the first four medications. Complicating matters, genetic mutations can increase psychotropic drug-related adverse events, including hospitalizations. A recent study indicates Myriad Genetics Inc.’s Genesight test can help minimize the risk of these negative events, with a reduction of nearly 40% in psychiatric-related hospitalizations and prescription of medications with significant gene-drug interactions.
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Silhouette of head, brain

Newco Neurosterix takes Addex’s preclinical assets private

April 3, 2024
By Nuala Moran
Addex Therapeutics has offloaded its portfolio of preclinical allosteric modulation drugs into Neurosterix, a new company that arrives on the scene with a $63 million series A round.
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Neurostar

Neurostar cleared for use in adolescent depression

March 26, 2024
By Annette Boyle
The U.S. FDA granted Neuronetics Inc. clearance for use of its Neurostar advanced therapy as an adjunctive treatment of major depressive disorder in patients aged 15 to 21, making it the first transcranial magnetic stimulation treatment (TMS) cleared for this age group, the company said.
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