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Home » Alzheimer’s disease

Articles Tagged with ''Alzheimer’s disease''

Illustration of amyloid plaques in Alzheimer's disease
Neurology/Psychiatric

After the first approvals, where does amyloid go from here?

April 4, 2024
By Anette Breindl
After decades of trying and dozens of failed trials, amyloid targeting has paid off with the first disease-modifying agents reaching the market. But success does not mean slam dunk. Aduhelm (aducanumab, Biogen Inc.) was dogged by controversy throughout its brief tenure, and Biogen pulled the plug on it in early 2024. Leqembi (lecanemab, Biogen Inc.) has received full approval. In this second installment of a three-part series on Alzheimer’s, BioWorld looks at the nuanced view of amyloid’s role in the disease.
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AI-generated illustration showing a brain in an hour glass with most of the sand at the bottom
Aging

Aging, and aging well, gives clues for dementia drug discovery

April 3, 2024
By Anette Breindl
Ironically, the first person to be diagnosed with what is now Alzheimer’s disease was missing its major risk factor. When she first began showing symptoms of dementia in 1901, Auguste Deter was not particularly old. Despite Deter’s case, aging is the largest risk factor for developing Alzheimer’s, by a large margin. But “geroscience has not been translated into drugs for Alzheimer’s disease,” Howard Fillit, Alzheimer’s Drug Discovery Foundation co-founder and chief scientific officer, told BioWorld. “We’re just starting to see that cross-fertilization now.” This first article of a three-part BioWorld series on Alzheimer’s disease looks at how a group of researchers, as well as some startups, are trying to approach Alzheimer’s via an aging lens.
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Adel CEO Seung-Yong Yoon at company headquarters in Seoul, South Korea

After amyloid beta, Adel seeks next big target for Alzheimer’s

April 2, 2024
By Marian (YoonJee) Chu
Alzheimer’s disease (AD) is recognized worldwide for its debilitating symptoms of declining cognitive function and gradual memory loss. What remains less clear is exactly what causes the neurodegenerative disease, and how to treat it. “Alzheimer’s disease is characterized by two key pathologies – beta-amyloid plaques and tau neurofibrillary tangles.” Seung-Yong Yoon, CEO of Adel Inc., told BioWorld. “Adel is looking to develop a tau-targeting drug, considering tau has been more correlated with AD symptom progression, and the industry’s need for tau pipelines.”
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Brain teaser
Neurology/Psychiatric

World Dementia Council seeks Alzheimer’s action in next 10 years

March 28, 2024
By Nuala Moran
Europe may still await its first disease-modifying Alzheimer’s drug after the EMA postponed its decision on Leqembi (lecanemab, Biogen Inc./Eisai Co. Ltd) on March 22, but leading members of the World Dementia Council were in an optimistic mood when they convened in London four days later. “We are working to make the inevitable happen earlier,” said Lenny Shallcross, executive director of WDC. “The inevitable will be rollout of medicines, rollout of better diagnostics and the improvement of care. All of those things over the next 10 years are inevitably going to happen.”
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Tree in the shape of human head losing leaves

World Dementia Council seeks Alzheimer’s action in next 10 years

March 27, 2024
By Nuala Moran
Europe may still await its first disease-modifying Alzheimer’s drug after the EMA postponed its decision on Leqembi (lecanemab, Biogen Inc./Eisai Co. Ltd) on March 22, but leading members of the World Dementia Council were in an optimistic mood when they convened in London four days later.
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Elderly woman and jigsaw puzzle

World Dementia Council seeks Alzheimer’s action in next 10 years

March 26, 2024
By Nuala Moran
Europe may still await its first disease-modifying Alzheimer’s drug after the EMA postponed its decision on Leqembi (lecanemab, Biogen Inc./Eisai Co. Ltd) on March 22, but leading members of the World Dementia Council were in an optimistic mood when they convened in London four days later.
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Aribio scores $770M deal in China for Alzheimer’s drug candidate

March 26, 2024
By Marian (YoonJee) Chu
South Korean biopharma Aribio Co. Ltd. signed a $770 million deal to sign off exclusive rights to its early Alzheimer’s disease drug, AR-1001 (mirodenafil), in China. The exclusive deal for marketing rights will total about ¥5.59 billion (US$770 million), which includes a non-refundable up-front payment of ₩120 billion (US$90 million) and potential milestone payments, along with royalties.
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EU flag, pills, syringe

EMA’s CHMP backs new antibiotic, oral PNH drug in March meeting

March 26, 2024
By Jennifer Boggs
The EMA’s Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion recommending approval of Pfizer Inc.’s Emblaveo (aztreonam-avibactam), an antibiotic combination that would offer a new option to patients with serious bacterial infections caused by multidrug-resistant gram-negative bacteria.
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Illustration of scientists conducting research on a mouse to find the missing puzzle piece
Neurology/Psychiatric

New murine models to study Clec7a in neurodegeneration

March 26, 2024
Microglia is known to play a crucial role in brain homeostasis, but this is lost during neurodegeneration.
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Aribio scores $770M deal in China for Alzheimer’s drug candidate

March 25, 2024
By Marian (YoonJee) Chu
South Korean biopharma Aribio Co. Ltd. signed a $770 million deal to sign off exclusive rights to its early Alzheimer’s disease drug, AR-1001 (mirodenafil), in China. The exclusive deal for marketing rights will total about ¥5.59 billion (US$770 million), which includes a non-refundable up-front payment of ₩120 billion (US$90 million) and potential milestone payments, along with royalties.
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