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Home » colorectal cancer

Articles Tagged with ''colorectal cancer''

Cancer

Selective oral small-molecule inhibitor of Aurora kinase B to fight multiple cancers

June 30, 2025
No Comments
Many cancers involve upregulation of Aurora kinase B, which helps deregulate normal cell cycling to drive tumor proliferation. The kinase should therefore be a good therapeutic target, yet no small-molecular inhibitor has been clinically approved despite more than two decades of effort.
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Illustration of T cells attacking tumor
Immuno-oncology

CDR-Life unveils T-cell engager targeting LGR5 as clinical candidate

June 27, 2025
No Comments
CDR-Life Inc. has announced CDR-609 as its next clinical candidate. Built on the company’s proprietary M-gager platform, CDR-609 is a novel T-cell engager targeting LGR5, a surface antigen widely expressed on common solid tumors, including colorectal, gastric, liver and pancreatic cancers.
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Oncolytic virus concept illustration
Immuno-oncology

Dual, tumor-specific TNFR2 and CD47 blockade using an oncolytic virus enhances anticancer immunity

June 13, 2025
No Comments
Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide. Recent advancements in immunotherapy have demonstrated the potential of targeting immune checkpoints and co-inhibitory pathways to enhance antitumor responses.
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Cancer cell, dropper, test tubes
Cancer

Silexion’s SIL-204 shows promise in pancreatic, colorectal and lung cancer cell lines

May 30, 2025
No Comments

Silexion Therapeutics Corp. has released preclinical data demonstrating the efficacy of its next-generation RNA interference (RNAi) therapeutic candidate, SIL-204, against human pancreatic, colorectal and lung cancer cell lines.


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AI-generated image for cancer cells observed under a microscope
Immuno-oncology

Engineered Mycobacterium smegmatis expressing anti-PD-L1/IL-15 triggers targeted antitumor immunity

May 28, 2025
No Comments
To overcome the current limitations of antitumor immunotherapy, in situ vaccine platforms based on intelligent microbes are gaining increased attention due to their ability to sustainably deliver drugs locally without causing severe systemic risks.
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Floating antibody drug conjugates
Immuno-oncology

ALX Oncology presents preclinical data, plans for ALX-2004

May 21, 2025
No Comments
ALX Oncology Holdings Inc. is set to begin phase I studies around the middle of this year with ALX-2004, an antibody-drug conjugate (ADC) for the treatment of EGFR-expressing solid tumors, following IND clearance last month.
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Cancer

New inhibitors of the WRN helicase show preclinical promise for MSI-high colorectal cancers

May 16, 2025
No Comments
Microsatellite instability (MSI), which results from defects in the DNA mismatch repair system, is an important biomarker in colorectal cancer. While the MSI-high (MSI-H) status predicts response to pembrolizumab, a commonly used immune checkpoint inhibitor in metastatic colorectal cancer, a subset of MSI-H patients still does not respond to this treatment.
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Illustration of cancer tumor
Cancer

UTR Therapeutics files IND application for UTRxM1-18 for c-MYC-driven cancers

May 9, 2025
No Comments
UTR Therapeutics Inc. has submitted an IND application to the FDA for UTRxM1-18, a novel therapeutic approach for targeting c-MYC-driven cancers. Pending approval, a first-in-human phase I trial is slated to begin next year.
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Colon cancer illustration

Safeheal secures €35M for endoluminal fecal bypass system

May 7, 2025
By Shani Alexander
Safeheal SAS raised €35 million (US$39.72 million) in an oversubscribed series C financing round for its temporary endoluminal fecal bypass system, Colovac, which is placed in the colon following colorectal resection. The funds will be used to complete an investigational device exemption pivotal study and speed up preparation for commercial launch of the device.
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Cancer

DNA topoisomerase I inhibitors disclosed in Shanghai Yiweikang Pharmaceutical patents

May 5, 2025
Shanghai Yiweikang Pharmaceutical Co. Ltd. has divulged camptothecin derivatives acting as DNA topoisomerase I inhibitors reported to be useful for the treatment of cancer.
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