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Home » antivirals

Articles Tagged with ''antivirals''

Infection

Discovery of novel aminoadamantane derivatives with potent anti-SARS-CoV-2 activity

Jan. 23, 2024
Researchers from Universidade Federal de Minas Gerais have published details on the discovery of novel anti-SARS-CoV-2 compounds with robust antiviral activity.
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Infection

CEA presents new antiviral compounds

Nov. 2, 2023
The Commissariat à l'énergie atomique (CEA) has divulged dihydroquinazolinone compounds reported to be useful for the treatment of viral infections.
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Transmission electron micrograph of H1N1.
Infection

Ligand-targeted immunotherapy demonstrates excellent antiviral activity in models of influenza infection

Oct. 23, 2023
Researchers from Eradivir Inc. and affiliated organizations presented the discovery and preclinical evaluation of EV-21, a dual mechanism antiviral immunotherapy for the treatment of influenza infections. EV-21 was designed as a ligand-targeted drug conjugate, developed by linking the neuraminidase inhibitor zanamivir to two distinct haptens that bind to two different naturally occurring antibodies in humans. As a result, the candidate acts though a dual mechanism of action, which consists of potent recruitment of the human immune system to recognize and destroy free viruses and virus-infected cells.
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Colorized transmission electron micrograph of SARS-CoV-2.
Infection

Next-generation oral SARS-CoV-2 Mpro inhibitor disclosed

Aug. 29, 2023
Viral proteases are well-established therapeutic targets in HIV and hepatitis C virus infections. Following the recent COVID-19 pandemic, one of the strategies in place is SARS-CoV-2 main protease (Mpro) inhibition, given the crucial role of SARS-CoV-2 Mpro in the replication of the virus.
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Infection

Beijing Entaiwei Medicine Science Technology discovers new prodrugs of β-D-N4-hydroxycytidine for viral infections

Aug. 23, 2023
Beijing Entaiwei Medicine Science Technology Co. Ltd. has described prodrugs of β-D-N4-hydroxycytidine reported to be useful for the treatment of viral infections.
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HIV/AIDS

Novel diarypyrimidine derivative shows significant anti-HIV activity

Aug. 17, 2023
Researchers from Shandong University and colleagues presented the characterization of [I] as the most active compound from a series of novel diarypyridimine derivatives intended to overcome resistance to NNRTI-resistant HIV-1 strains. The compound displayed EC50 values of 0.0010 and 0.18 µM against HIV IIIB and RES056 strains, respectively.
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Viruses
Infection

AMP mimicking peptoids exert antiviral activity through membrane-specific mechanism

Aug. 9, 2023
Viruses can evolve and mutate rapidly to establish resistance, making the development of durable and effective antiviral therapies challenging. The innate immune system has the ability to target pathogen membranes through the expression of short antimicrobial peptides (AMPs), which exert direct antimicrobial activity and can therefore act as antiviral agents against enveloped viruses. Researchers from New York University and affiliated organizations have presented the discovery and preclinical evaluation of novel family of AMP mimetics, called peptoids, as potential new antiviral candidates.
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Creative rendition of SARS-CoV-2 virus particles.
Infection

Infex Therapeutics nominates new lead pan-coronavirus antiviral candidate

Aug. 9, 2023
Researchers from Infex Therapeutics Ltd. have announced the nomination of a clinical candidate for its in-house developed COV-X program. The novel first-in-class small molecule is an oral pan-coronavirus papain-like protease (PLpro) inhibitor, which was selected based on preclinical data that demonstrated in vivo efficacy of the candidate a murine model of SARS-CoV-2.
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Transmission electron microscopic image of numerous Enterovirus-D68 (EV-D68) virions
Infection

New pleconaril-based molecule shows efficacy in preclinical models of Enterovirus infection

July 26, 2023
Researchers from Collaborations Pharmaceuticals Inc. recently reported the discovery and preclinical evaluation of a novel pleconaril-based molecule, 11526092, being develop as an antiviral agent against enteroviruses.
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Coronavirus and antibodies
Infection

New multispecific antibody platform offers increased potency and breadth against SARS-CoV-2

June 7, 2023
Scientists from the Hospital for Sick Children Research Institute and collaborators have reported the application of a multispecific, multiaffinity antibody (Multabody, MB) platform derived from the human apoferritin protomer to enable the multimerization of antibody fragments against SARS-CoV-2. These MBs showed high potency to neutralize SARS-CoV-2 even at lower concentrations than their corresponding MAb counterparts.
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