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BioWorld - Friday, May 23, 2025
Home » multiple myeloma

Articles Tagged with ''multiple myeloma''

Multiple myeloma cells in the bone marrow.
Cancer

Preclinical data on selective IKZF1/3 degrader ICP-490 reported

April 21, 2023
Several immunomodulatory drugs (IMiDs) such as lenalidomide have greatly improved the management of multiple myeloma (MM)...
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Multiple myeloma illustration
Cancer

M-3913, a first-in-class ERSM with efficacy in models of MM and NSCLC

April 18, 2023
At the AACR meeting this week, EMD Serono Inc. reported the discovery of a novel endoplasmic reticulum (ER) stress modulator (ERSM), M-3913.
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Global currency

Oricell nets $45M in series B round, eyes the global market

March 7, 2023
By Doris Yu
Oricell Therapeutics Co. Ltd. raised $45 million in a series B1 round to expand in the U.S. market. RTW Investments LP and the Qatar Investment Authority led the financing, which followed the completion of a $125 million series B round in July 2022. Shanghai-based Oricell plans to use the new funds to support the clinical development of its lead candidates, including Oricar-017, in the U.S.
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Oricell nets $45M in series B round, eyes the global market

March 1, 2023
By Doris Yu
Oricell Therapeutics Co. Ltd. raised $45 million in a series B1 round to expand in the U.S. market. RTW Investments LP and the Qatar Investment Authority led the financing, which followed the completion of a $125 million series B round in July 2022. Shanghai-based Oricell plans to use the new funds to support the clinical development of its lead candidates, including Oricar-017, in the U.S.
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Immuno-oncology

CB-011, allogeneic BCMA-specific CAR-T cells engineered to prevent immune cell-mediated rejection

Feb. 21, 2023
Researchers from Caribou Biosciences Inc. presented preclinical data for the novel BCMA-specific allogeneic CAR T-cell therapy candidate, CB-011, being developed for the treatment of relapsed or refractory multiple myeloma. A genome editing strategy was implemented in the production of CB-011 to blunt CAR T-cell rejection by both patient T cells and natural killer (NK) cells.
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FDA fast tracks new drug procedures for bone marrow cancer treatment

Feb. 16, 2023
By Doris Yu
The U.S. FDA granted Nanjing Iaso Biotherapeutics Co. Ltd. both regenerative medicine advanced therapy and fast track designations for its new drug, BCMA CAR T-cell therapy CT-103A (equecabtagene autoleucel), allowing it to speed up development and commercialization in the U.S. for the treatment of relapsed/refractory multiple myeloma.
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Glass yen/yuan symbol

Iaso Bio nets ¥500M as it eyes China nod for CAR T therapy

Jan. 19, 2023
By Doris Yu
Iaso Biotherapeutics Inc. raised ¥500 million (US$75 million) in a series C1 round as looks for its first drug approval by China after its NDA was accepted for what is claimed to be the first B-cell maturation antigen-targeting CAR T-cell therapy in China.
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China in red on globe

Carsgen out-licenses China rights to Huadong for BCMA CAR T for $152M

Jan. 17, 2023
By Tamra Sami
CAR T specialist Carsgen Therapeutics Holdings Ltd. out-licensed commercial rights for its B-cell maturation antigen (BCMA) CAR T therapy, CT-053, in mainland China to Huadong Medicine Co Ltd. in a deal worth up to $152 million.
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Multiple myeloma illustration
Immuno-oncology

CD38xCD3 bispecific antibody IGM-2644 possesses potent efficacy against myeloma with reduced fratricide

Jan. 10, 2023
Researchers at GM Biosciences Inc. have reported developed a novel CD38xCD3 bispecific IgM T-cell engager IGM-2644 with 10 binding sites for human CD38 (Kd=0.27nM; measured by biolayer interferometry) and one anti-CD3 site (Kd=2.1nM) designed to reduce safety concerns.
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Multiple myeloma cells in the bone marrow.
Immuno-oncology

Sanofi presents data on anti-BCMA NK cell engager SAR’514 for multiple myeloma

Jan. 5, 2023
Multiple myeloma (MM) represents about 10% of all blood cancers, remaining an incurable disease with a 5-year overall survival rate of 56%. B-cell maturation antigen (BCMA) is a receptor in the cell surface that is highly expressed in malignant plasma cells, and in normal cells, that promotes cell proliferation and survival by binding to APRIL and BAFF ligands.
Read More
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