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Home » multiple myeloma

Articles Tagged with ''multiple myeloma''

Cancer

SKY-1214 overcomes nonresponse in B-cell malignancies

Dec. 19, 2024
Skyhawk Therapeutics Inc. presented preclinical data on SKY-1214, a splicing modulator of the Fanconi anemia pathway.
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Multiple myeloma illustration
Cancer

OPN-6602 exhibits potency against multiple myeloma in vitro and in vivo

Dec. 13, 2024
Opna Bio AG has presented promising data regarding their EP300/CBP inhibitor OPN-6602 for the treatment of multiple myeloma (MM). The inhibition of EP300/CBP causes cell cycle arrest and apoptosis in MM cells due to suppression of interferon regulatory factor 4 (IRF4) and MYC repression.
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M&A letters over missing puzzle pieces

Roche snaps up Poseida for $1.5B

Nov. 26, 2024
By Lee Landenberger
Poseida Therapeutics Inc. is being bought out for $1.5 billion by partner Roche Holdings Inc. to develop allogeneic CAR T therapies to treat hematologic malignancies. The two companies began their collaboration in August 2022, a deal that brought Poseida $110 million up front and another $110 million in near-term milestone payments. With the acquisition, Roche plans to develop CAR T programs for solid tumors and autoimmune diseases with Poseida's genetic engineering platform and preclinical programs.
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Keymed, Platina sign $626M deal for bispecific antibody CM-336

Nov. 19, 2024
By Tamra Sami
Keymed Biosciences Co. Ltd. is out-licensing global rights, excluding China, for its bispecific antibody, CM-336, to Platina Medicines Ltd. in a deal worth up to $626 million plus sales royalties.
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Keymed, Platina sign $626M deal for bispecific antibody CM-336

Nov. 18, 2024
By Tamra Sami
Keymed Biosciences Co. Ltd. is out-licensing global rights, excluding China, for its bispecific antibody, CM-336, to Platina Medicines Ltd. in a deal worth up to $626 million plus sales royalties.
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CAR T cell attacking cancer cells
Immuno-oncology

Third development candidate nominated under Poseida and Roche’s allogeneic CAR T collaboration

Oct. 18, 2024
Poseida Therapeutics Inc. has announced the nomination of a new development candidate under its collaboration with F. Hoffmann-La Roche Ltd., triggering a milestone payment from Roche to Poseida.
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Multiple myeloma cells in the bone marrow.
Cancer

Mcl-1 inhibitor KS-18 fights resistance in multiple myeloma models

Oct. 10, 2024
Researchers from Rowan University, Pennsylvania State University, and affiliated organizations presented preclinical data for the selective Mcl-1 inhibitor, KS-18, in models of multiple myeloma (MM).
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Multiple myeloma art concept
Cancer

Carbohydrate-based antimyeloma therapy described

Sep. 4, 2024
Thyroid hormone receptor-interacting protein 13 (TRIP13) is overexpressed in multiple myeloma (MM), where it is associated with progression and poor prognosis.
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Stamp with EU flag

EU clears Regeneron’s Ordspono, Merck’s Winrevair, ARS’ Eurneffy

Aug. 26, 2024
By Nuala Moran
Five months after getting a complete response letter from the U.S. FDA, Regeneron Pharmaceuticals Inc. has landed conditional European marketing approval for odronextamab, a bispecific antibody for treating lymphoma. Now named Ordspono, the approval is for treating adult patients with relapsed or refractory follicular lymphoma or diffuse large B-cell lymphoma, after two or more lines of therapy. The European Commission also approved Merck & Co. Inc.’s Winrevair (sotatercept) for pulmonary arterial hypertension and ARS Pharmaceuticals Inc.'s Eurneffy (inhaled epinephrine) for anaphylaxis.
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CRL no alarm bell for Regeneron’s linvoseltamab in multiple myeloma

Aug. 21, 2024
By Randy Osborne

Regeneron Pharmaceuticals Inc. suffered an unsurprising hitch in the form of a complete response letter (CRL) related to linvoseltamab, a bispecific antibody designed to bridge B-cell maturation antigen on multiple myeloma cells containing CD3-expressing T cells, for relapsed/refractory multiple myeloma.


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