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Home » multiple myeloma

Articles Tagged with ''multiple myeloma''

Multiple myeloma cells in the bone marrow.
Immuno-oncology

Trispecific antibody SIM-0500 approved for trials in the US and China for multiple myeloma

March 12, 2024
Simcere Zaiming, a subsidiary of Simcere Pharmaceutical Group Ltd., has received approval from the FDA and China’s National Medical Products Administration (NMPA) to conduct clinical trials with SIM-0500 in patients with relapsed or refractory multiple myeloma.
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Multiple myeloma illustration

NMPA clears Carsgen’s BCMA CAR T for refractory multiple myeloma

March 5, 2024
By Tamra Sami

China’s NMPA has approved Carsgen Therapeutics Holdings Ltd.’s NDA for its B-cell maturation antigen (BCMA)-targeted CAR T-cell therapy, zevorcabtagene autoleucel (CT-053, zevor-cel), for treating adults with relapsed or refractory (r/r) multiple myeloma (MM) who have progressed after at least three prior lines of therapy, including a proteasome inhibitor and immunomodulatory agent.


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Multiple myeloma illustration

NMPA clears Carsgen’s BCMA CAR T for refractory multiple myeloma

March 1, 2024
By Tamra Sami

China’s NMPA has approved Carsgen Therapeutics Holdings Ltd.’s NDA for its B-cell maturation antigen (BCMA)-targeted CAR T-cell therapy, zevorcabtagene autoleucel (CT-053, zevor-cel), for treating adults with relapsed or refractory (r/r) multiple myeloma (MM) who have progressed after at least three prior lines of therapy, including a proteasome inhibitor and immunomodulatory agent.


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Immuno-oncology

Sanofi’s trispecific MAb outperfoms conventional T-cell-engaging bispecific antibodies

March 1, 2024
T-cell-engaging antibodies (TCEs) are synthetic molecules that redirect T cells to bind to the antigens on the surface of cancer cells to promote tumor elimination. In the case of multiple myeloma (MM), the approvals of anti-CD38 monoclonal antibodies (MAbs), chimeric antigen receptor T-cell therapies (CAR T) targeting B-cell maturation antigen (BCMA) or, more recently, bispecific TCEs represent great advances, but some patients still relapse after treatment.
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Cancer

Vernalis and Servier discover new Mcl-1 inhibitors

Feb. 12, 2024
Les Laboratories Servier SAS and Vernalis (R&D) Ltd. have described induced myeloid leukemia cell differentiation protein Mcl-1 inhibitors acting as apoptosis inducers reported to be useful for the treatment of cancer and autoimmune diseases.
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As ODAC questions loom, 2seventy ‘doubles down’ on Abecma

Jan. 30, 2024
By Randy Osborne
2seventy bio Inc. shares (NASDAQ:TSVT) rose 15% or 52 cents, to close Jan. 30 at $4.01 on word that the Cambridge, Mass.-based firm is selling its R&D pipeline to Regeneron Pharmaceuticals Inc., which will move the work forward by way of a new company called Regeneron Cell Medicines.
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Blister beetle on a flower
Cancer

Blistering agent derivative exerts anticancer activity

Jan. 19, 2024
Cantharidin, a natural product coming from blister beetles, has anti-proliferative activity in several cancer cell lines such as leukemia, myeloma or colon cancer cells.
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Cancer

Shanghai Institute of Materia Medica divulges new CRBN/target protein interaction inducers

Jan. 18, 2024
Shanghai Institute of Materia Medica of the Chinese Academy of Sciences has synthesized molecular glue compounds targeting protein cereblon (CRBN) acting as CRBN/target protein interaction inducers reported to be useful for the treatment of cancer.
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Natural killer cell attacking cancer cell
Immuno-oncology

Transcription factors Ikaros and Aiolos drive immune response

Jan. 8, 2024
By Tamra Sami
Researchers at Monash University in Melbourne have discovered that transcription factors Ikaros and Aiolos work by binding to AP-1 transcriptional complexes and driving their transcription, which regulates thousands of genes in the human body.
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Cancer

Kronos Bio nominates development candidate for multiple myeloma

Dec. 19, 2023
Kronos Bio Inc. has nominated a new development candidate, KB-9558, which targets the lysine acetyltransferase (KAT) domain of p300, a critical node of the IRF4 transcription regulatory network (TRN), which is a key driver in multiple myeloma.
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