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Home » multiple myeloma

Articles Tagged with ''multiple myeloma''

Bispecific antibodies with heavy chain in green and pink, light chain in blue and yellow
Immuno-oncology

Human T cells armed with bispecific T cell engaging Abs fight myeloma

Dec. 15, 2023
In a recent publication in Scientific Reports, researchers at City of Hope and collaborators presented a novel CS1 bsAb, called CS1-dbBiTE, conjugating an intact anti-CS1 antibody (elotuzumab) and an anti-human OKT3 antibody at their respective hinge regions using Click chemistry.
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ASH 2023: Multiple new dosing regimens for multiple myeloma

Dec. 12, 2023
By Brian Orelli
Multiple studies at the 65th American Society of Hematology Annual Meeting 2023 have the potential to change the treatment paradigm for first-line treatment of multiple myeloma.
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Cancer

DCZ-5417 suppresses multiple myeloma progression, study shows

Dec. 4, 2023
Norcantharidin is an active ingredient in Chinese traditional medicine that has activity against several cancer types, but its application is limited in the clinic due to toxicity and a narrow treatment window. Researchers from Tongji University and the Shanghai Institute of Materia Medica have recently described a derivative of norcantharidin – DCZ-5417 – for the potential treatment of multiple myeloma (MM).
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Multiple myeloma illustration

GSK’s Blenrep makes a comeback in multiple myeloma

Nov. 27, 2023
By Lee Landenberger
GSK plc is looking at a comeback for Blenrep (belantamab mafodotin) as an interim efficacy analysis brought the company good news. Almost exactly a year ago, phase III confirmatory study data for the already-approved multiple myeloma drug fell short of the U.S. FDA’s accelerated approval requirements, so the agency asked GSK to take the drug off the market for the indication.
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Multiple myeloma cells in the bone marrow.
Cancer

Abbvie’s Mcl-1 inhibitor ABBV-467 shows efficacy in tumor models

Nov. 24, 2023
Disrupting apoptosis is a mechanism that cancerous cells use to avoid being killed; this can be performed by overexpressing pro-survival factors, such as induced myeloid leukemia cell differentiation protein Mcl-1. Researchers from Abbvie Inc. have recently published preclinical data on a potent and selective Mcl-1 inhibitor, ABBV-467, for the treatment of hematologic cancers.
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Gilead’s Kite invests $285M more, expands Arcellx CAR T deal to include lymphoma

Nov. 15, 2023
If there had been any lingering market concerns following the temporary partial clinical hold earlier this year for Arcellx Inc.’s multiple myeloma CAR T-cell therapy, CART-ddBCMA, they were likely put to rest as partner Gilead Sciences Inc.’s Kite unit expanded the scope of the firms’ late 2022 collaboration to include lymphomas. At the same time, Kite exercised an option to negotiate a license for Arcellx’s ARC-Sparx program, ACLX-001, in multiple myeloma.
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Biolinerx shares climb after $270M+ motixafortide deal in Asia with Gloria Bio

Nov. 7, 2023
By Marian (YoonJee) Chu
Israeli biotech Biolinerx Ltd. will hand off the rights to its stem cell mobilizer, motixafortide, in Asia to China’s Gloria Biosciences Co. Ltd. via an out-licensing deal worth up to $280 million, news that sent stocks soaring nearly 13% on Oct. 31.
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ASH preview: Among the flood of abstracts, Arcellx’s phase I data move its stock

Nov. 2, 2023
By Lee Landenberger
Among the avalanche of abstracts for the upcoming American Society of Hematology (ASH) annual conference released early on Nov. 2 were data from Arcellx Inc.’s phase I study of CART-ddBCMA in patients with relapsed or refractory multiple myeloma. The results caught investors’ attention as the company’s stock (NASDAQ:ACLX) jumped 18.5% upward to close at $40.77 per share.
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Biolinerx shares climb after $270M+ motixafortide deal in Asia with Gloria Bio

Nov. 1, 2023
By Marian (YoonJee) Chu
Israeli biotech Biolinerx Ltd. will hand off the rights to its stem cell mobilizer, motixafortide, in Asia to China’s Gloria Biosciences Co. Ltd. via an out-licensing deal worth up to $280 million, news that sent stocks soaring nearly 13% on Oct. 31.
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3D illustration of acute lymphoblastic leukemia in blood.

Mission accomplished: Mission Bio launches MRD assay for blood cancer

Sep. 28, 2023
By Annette Boyle
Mission Bio Inc. released its Tapestri single-cell minimal residual disease (MRD) assay for acute myeloid leukemia (AML) on September 26, with the goal of enabling greater personalization of care for patients with blood cancers. The test can provide insights into the progression of AML and help identify targets for treatment in addition to identifying patients truly experiencing relapse as distinct from having pre-leukemic or precursor clones.
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