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Home » non-small-cell lung cancer

Articles Tagged with ''non-small-cell lung cancer''

Starpharma’s dendrimer platform meets metastatic cancer endpoints in phase II

Jan. 2, 2024
By Tamra Sami
Starpharma Holdings Ltd.’s DEP docetaxel phase II trial met its primary endpoints, demonstrating antitumor activity in multiple advanced, metastatic cancers, including pancreatic, gastro-esophageal, non-small-cell lung cancer and cholangiocarcinoma.
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Allorion joins a $540M lung cancer deal with Astrazeneca

Jan. 2, 2024
By Lee Landenberger
Allorion Therapeutics Inc. could receive $40 million in up-front and near-term payments from Astrazeneca plc in the companies’ exclusive option and global license deal. The two plan to develop and commercialize an L858R mutated allosteric inhibitor for treating EGFR inhibitor-mutant non-small-cell lung cancer.
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MSD, Roche highlight new sub analysis data at ESMO Asia in Asia-prevalent cancers

Dec. 28, 2023
By Tamra Sami
MSD had a banner year at the ESMO Asia Congress earlier this month, presenting 14 abstracts on eight different types of cancers, including gastric, esophageal, colorectal, biliary tract, kidney, urothelial, breast and gynecological cancers. Ten of these studies were focused on Asian-related data. Roche AG, meanwhile, presented Asia-specific results from the phase III Alina study in patients with ALK-positive early stage non-small-cell lung cancer.
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Biomarkers

ITPRIPL1 may have diagnostic, prognostic value in lung cancer

Dec. 28, 2023
From previous reports, there is evidence that cancer cells overexpress inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1) to evade the immune system and promote tumor growth. Tissue samples from patients with non-small-cell lung cancer (NSCLC) were collected and used for studying the expression (intensity and extent) patterns of ITPRIPL1 and its diagnostic and prognostic value in this cancer type.
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Antibody-drug tusamitamab ravtansine fails in phase III; Sanofi bows out

Dec. 22, 2023
By Nuala Moran
As its pharma peers continue to place big bets on antibody-drug conjugates (ADCs), Sanofi SA is ditching the only advertised ADC program in its pipeline, after it failed an independent interim analysis.
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Starpharma’s dendrimer platform meets metastatic cancer endpoints in phase II

Dec. 22, 2023
By Tamra Sami
Starpharma Holdings Ltd.’s DEP docetaxel phase II trial met its primary endpoints, demonstrating antitumor activity in multiple advanced, metastatic cancers, including pancreatic, gastro-esophageal, non-small-cell lung cancer and cholangiocarcinoma.
Read More
Cancer

Roche divulges EGFR mutant inhibitors for NSCLC

Dec. 4, 2023
An F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. patent describes indole derivatives acting as EGFR L858R mutant, T790M/L858R double mutant, T790M/L858R/C797S triple mutant and/or L858R/C797S double mutant allosteric inhibitors reported to be useful for the treatment of non-small-cell lung cancer (NSCLC).
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Lung cancer illustration
Cancer

China Pharmaceutical University reports discovery of novel EGFR triple-mutation inhibitors

Dec. 1, 2023
Most patients with non-small-cell lung cancer (NSCLC) develop acquired drug resistance to EGFR inhibitors. Osimertinib, a third-generation inhibitor, often sees its therapeutic effect reduced due to the C797S mutation of EGFR exon 20, which blocks the binding of Cys797 to osimertinib.
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Epidermal growth factor receptor (EGFR)
Cancer

Dana-Farber Cancer Institute advances allosteric EGFR inhibitor EAI-432

Dec. 1, 2023
Researchers at Dana-Farber Cancer Institute are advancing a fourth-generation allosteric EGFR inhibitor, EAI-432, to treat non-small-cell lung cancer driven by mutations in the EGFR gene, particularly the L858R mutation.
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Gene editing illustration
Immuno-oncology

KSQ’s CRISPR/Cas9 eTIL therapy IND cleared by FDA

Nov. 30, 2023
KSQ Therapeutics Inc., in collaboration with The University of Texas MD Anderson Cancer Center and the Cell Therapy Manufacturing Center (CTMC), have announced FDA clearance of an IND application for a phase I/II study of KSQ-001EX, KSQ’s lead engineered tumor-infiltrating lymphocyte (eTIL) program.
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