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Home » non-small-cell lung cancer

Articles Tagged with ''non-small-cell lung cancer''

Medilink, Biontech ink potential $1B for HER3-targeting ADC

Oct. 17, 2023
In its first significant partnering deal since being founded in 2020, Medilink Therapeutics Co. Ltd. licensed exclusive global rights to an antibody-drug conjugate (ADC) targeting HER3 to Biontech SE in exchange for an up-front payment of $70 million, with the possibility for additional payments tied to development, regulatory and commercial milestones exceeding $1 billion. Medilink retains rights in mainland China, Hong Kong Special Administrative Region and Macau Special Administrative Region.
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Lung cancer illustration

With positive phase II interim data in NSCLC, Abion to advance MET-TKI to combo trial

Oct. 13, 2023
By Marian (YoonJee) Chu
Precision cancer biotech Abion Inc. announced a positive interim phase II readout for ABN-401, its novel c-mesenchymal-epithelial transition (c-MET)-targeting tyrosine kinase inhibitor (TKI) for advanced non-small-cell lung cancer (NSCLC), lighting a runway to its next trial as a combination regimen.
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Medilink, Biontech ink potential $1B for HER3-targeting ADC

Oct. 12, 2023
In its first significant partnering deal since being founded in 2020, Medilink Therapeutics Co. Ltd. licensed exclusive global rights to an antibody-drug conjugate (ADC) targeting HER3 to Biontech SE in exchange for an up-front payment of $70 million, with the possibility for additional payments tied to development, regulatory and commercial milestones exceeding $1 billion. Medilink retains rights in mainland China, Hong Kong Special Administrative Region and Macau Special Administrative Region.
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Cancer

Jiangsu Hansoh Pharmaceutical and Shanghai Hansoh Biomedical patent EGFR inhibitors

Oct. 10, 2023
A recent Jiangsu Hansoh Pharmaceutical Group Co. Ltd. and Shanghai Hansoh Biomedical Co. Ltd. patent describes nitrogen-containing heterocyclic derivatives acting as EGFR (del19 mutant) inhibitors and reported to be useful for the treatment of non-small-cell lung cancer.
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Mirati building

Post-Lumakras adcom, BMS makes $5.8B move for Mirati; Sanofi to counter?

Oct. 9, 2023
By Randy Osborne
Just as Wall Street had begun mulling the possible fallout of the regulatory vote against full U.S. FDA clearance for Amgen Inc.’s KRAS G12C therapy for non-small-cell lung cancer, a new – albeit not entirely unexpected – development cropped up in the space. Mirati Therapeutics Inc. disclosed Oct. 9 that Bristol Myers Squibb Co. (BMS) is offering to take over the firm in a deal that could be worth as much as $5.8 billion, historically one of the larger takeovers for 2023.
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3D illustration and light micrograph of lung cancer.
Cancer

Radiopharm’s radiotherapeutic RAD-204 cleared to enter clinic in Australia for PD-L1-positive NSCLC

Oct. 9, 2023
Radiopharm Theranostics Ltd. has been granted human research ethics committee (HREC) approval to commence a first-in-human phase I study in Australia for RAD-204, the company’s radiotherapeutic for patients with PD-L1-positive non-small-cell lung cancer (NSCLC).
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Xray showing lung cancer on tablet

Systemic polemic: ODAC panel BICRs over bias in Amgen’s Lumakras confirmatory trial, says no

Oct. 5, 2023
By Randy Osborne
The dark cloud of what the U.S. FDA called potential “systemic bias” rained on Amgen Inc.’s bid for full approval of Lumakras (sotorasib), a KRAS-G12C inhibitor that was granted accelerated approval in May 2021 for locally advanced or metastatic non-small-cell lung cancer after at least one systemic therapy.
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Lumakras

Regulatory COPs grill ODAC briefing docs ahead of Lumakras adcom

Oct. 4, 2023
By Randy Osborne
Bad news for Amgen Inc. could mean upside for Mirati Therapeutics Inc., though the meeting of the U.S. FDA’s Oncologic Drugs Advisory Committee (ODAC) has yet to tell the tale regarding Lumakras (sotorasib), the former’s KRAS-G12C inhibitor.
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Concept illustration of cell-free circulating tumor DNA.
ASTRO 2023

Study suggests that circulating tumor DNA is predictive of response to therapy in NSCLC

Oct. 4, 2023
By Mark McCarty

Providing the right therapy at the right time has proven more difficult in the world of cancer than in other disease areas thanks to the variability in treatment response, but a new study hints that this problem may be at least partly solved for non-small cell lung cancer (NSCLC). A study presented at this year’s meeting of the American Society for Radiation Oncology (ASTRO) in San Diego shows that circulating tumor DNA (ctDNA) can provide therapeutic guidelines for oligometastatic forms of the disease, including when high-dose radiation therapy may or may not be indicated.


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Lung cancer illustration
Immuno-oncology

Ocean Biomedical’s anti-CHI3L1 antibody demonstrates tumor reduction in EGFR-mutant lung cancer

Oct. 4, 2023
Ocean Biomedical Inc. has demonstrated the effectiveness of its anti-chitinase 3-like-1 (CHI3L1) antibody in suppressing and reversing tumor growth in studies of epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) cells.
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