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Home » non-small-cell lung cancer

Articles Tagged with ''non-small-cell lung cancer''

Cancer

Preclinical characterization of novel TS inhibitor DG-1 presented

Aug. 23, 2023
Thymidylate synthase (TS) is an enzyme essential for DNA synthesis and cell proliferation and is a potential oncoprotein itself. Consequently, TS is considered a molecular target for malignant tumors.
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Antibodies attacking cancer cell
Immuno-oncology

Novarock's bispecific antibody NBL-028 cleared to enter clinic for CLDN6-expressing tumors

Aug. 18, 2023
Novarock Biotherapeutics Ltd., a subsidiary of CSPC Pharmaceutical Group Ltd., has received FDA approval of its IND application for NBL-028, a CLDN6-CD137 bispecific antibody.
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Cancer

Shanghai Lisen Imprinting Pharmaceutical Technology describes new EGFR inhibitors for lung cancer

Aug. 10, 2023
Shanghai Lisen Imprinting Pharmaceutical Technology Co. Ltd. has disclosed EGFR (HER1; erbB1) inhibitors reported to be useful for the treatment of small-cell lung (SCLC) and l lung cancer (NSCLC).
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The epidermal growth factor receptor in the inactive (left) and active (right) form.
Cancer

Discovery of novel EGFR triple-mutation inhibitor with efficacy in preclinical models of NSCLC

July 24, 2023
Researchers from Jiangsu Hansoh Pharmaceutical Group Co. Ltd. presented the discovery and preclinical evaluation of novel EGFR(T790M/C797S) inhibitors for the treatment of mutant non-small-cell lung cancer (NSCLC).
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EMA icons

CHMP says no to Mirati’s lung cancer treatment

July 21, 2023
By Lee Landenberger
Mirati Therapeutics Inc.’s cancer treatment Krazati (adagrasib) is having a tough time outside the U.S. The EMA’s Committee for Medicinal Products for Human Use (CHMP) came out with a negative opinion on an MAA for treating KRAS G12C-mutated advanced non-small-cell lung cancer (NSCLC). The ruling came with a flurry of positive CHMP opinions for companies, including Abbvie Inc., Beigene Ltd. and the Janssen Pharmaceutical Cos., plus a mixed result for Ipsen SA after a stumble earlier this week.
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Tumor microenvironment
Cancer

Circle Pharma selects dual cyclin A/B inhibitor as clinical candidate

July 20, 2023
Circle Pharma Inc. has selected CID-078 as its first clinical development candidate. CID-078 is an orally bioavailable macrocycle with dual cyclin A and B inhibitory activity that drives synthetic lethality in multiple tumor types.
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Lung cancer illustration
Cancer

Novel selenium compound RY-1-92 demonstrates preclinical antitumor activity in NSCLC

July 18, 2023
Lung cancer is the second most frequently diagnosed cancer worldwide where the non...
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Kelun-Biotech raises $174M in Hong Kong IPO to race in ADC market

July 11, 2023
Kelun-Biotech Biopharmaceutical Co. Ltd. raised HK$1.36 billion (US$174 million) in an IPO in Hong Kong to support its push into the increasingly competitive antibody-drug conjugate (ADC) market in China.
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With MFDS expanded approval, Yuhan's Leclaza moving to first-line NSCLC treatment

July 11, 2023
By Marian (YoonJee) Chu
South Korean pharmaceutical giant Yuhan Corp. gained Korea’s MFDS approval to expand indications for its potent oral third-generation tyrosine kinase inhibitor Leclaza (lazertinib) as a first-line treatment for EGFR T790M mutation-positive non-small-cell lung cancer (NSCLC).
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Xray showing lung cancer on tablet

Astrazeneca, Daiichi won’t cop to TROP2 grade 5s; OS data from phase III yet to emerge

July 11, 2023
By Randy Osborne
The trophoblast cell surface antigen 2 (TROP2) class chalked mix news by way of Astrazeneca plc and Daiichi Sankyo Co. Ltd. as the pair disclosed phase III data from the closely watched Tropion-Lung 1 trial with datopotamab deruxtecan (dato-dxd) against non-small-cell lung cancer.
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