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Home » non-small-cell lung cancer

Articles Tagged with ''non-small-cell lung cancer''

Xray showing lung cancer on tablet

Astrazeneca, Daiichi won’t cop to TROP2 grade 5s; OS data from phase III yet to emerge

July 3, 2023
By Randy Osborne
The trophoblast cell surface antigen 2 (TROP2) class chalked mix news by way of Astrazeneca plc and Daiichi Sankyo Co. Ltd. as the pair disclosed phase III data from the closely watched Tropion-Lung 1 trial with datopotamab deruxtecan (dato-dxd) against non-small-cell lung cancer.
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Cancer

Chia Tai Tianqing Pharmaceutical describes new EGFR inhibitors

June 30, 2023
Chia Tai Tianqing Pharmaceutical Group Co. Ltd. has identified EGFR (HER1; erbB1) wild-type and/or mutant inhibitors reported to be useful for the treatment of cancer, particularly non-small-cell lung cancer (NSCLC).
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No longer in the rough: Black Diamond posts strong phase I NSCLC data

June 27, 2023
By Lee Landenberger
The dose-escalation portion of Black Diamond Therapeutics Inc.’s phase I study of BDTX-1535 for treating non-small-cell lung cancer (NSCLC) produced strong data that moved the market in a big way.
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Cancer

Arvinas and Genentech discover new SMARCA2 degradation inducers

June 23, 2023
Arvinas Operations Inc. and Genentech Inc. have described proteolysis targeting chimera (PROTAC) compounds comprising a Von Hippel-Lindau (VHL) E3 ubiquitin ligase binding moiety coupled to a probable global transcription activator SNF2L2 (SMARCA2; BAF190B; SNF2-α) targeting moiety through a linker reported to be useful for the treatment of cancer, including non-small-cell lung cancer.
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Handshake behind digital globe

In $392M deal, C4 and Betta partner in China on preclinical NSCLC drug

June 6, 2023
By Karen Carey
In a deal potentially worth $392 million, C4 Therapeutics Inc. signed with Betta Pharmaceuticals Co. Ltd. to develop and market an orally bioavailable BiDAC degrader for non-small-cell lung cancer (NSCLC).
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Australian coins and bills

Immutep to raise AU$80M to advance LAG-3 immunotherapy pipeline

June 6, 2023
By Tamra Sami
Immutep Ltd. announced an AU$80 million (US$52.1 million) capital raise that consists of a AU$50 million placement and a AU$30 million entitlement offer to eligible shareholders to fund clinical programs for lead candidate eftilagimod (IMP-321, efti), a lymphocyte activation gene-3 (LAG-3) fusion protein and major histocompatibility complex class II agonist that stimulates both innate and adaptive immunity for treating cancer.
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Cancer

Abbvie and Calico researchers discover new protein tyrosine phosphatase inhibitors

June 2, 2023
Researchers at Abbvie Inc. and Calico Life Sciences LLC have described protein tyrosine phosphatase inhibitors, particularly tyrosine-protein phosphatase non-receptor type 2 (PTPN2; TCPTP) and/or PTPN1 (PTP-1B), reported to be useful for the treatment of non-small-cell lung cancer (NSCLC).
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Tumor necrosis factor (TNF), a cytokine involved in inflammation processes
Immuno-oncology

Bioinvent's anti-TNFR2 antibody BI-1910 cleared to enter clinic

June 2, 2023
Bioinvent International AB has received IND...
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Cancer

Macrophage senescence promotes lung cancer progression

June 2, 2023
By Mar de Miguel
With age, senescent cells become detrimental to tissues. Mayo Clinic scientists have observed this phenomenon in the lung alveoli, where senescent macrophages accumulated in aging tissue and in early stages of non-small-cell lung cancer (NSCLC) driven by the Kras oncogene. “We found that the macrophages were present in the earliest stages of the disease. Strategies targeting these cells for elimination or preventing their accumulation would be worthwhile to test in other conditions (assuming we find they occur),” Darren Baker, a Mayo Clinic senescent cell biologist and senior author of the study, told BioWorld.
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Australian coins and bills

Immutep to raise AU$80M to advance LAG-3 immunotherapy pipeline

June 1, 2023
By Tamra Sami
Immutep Ltd. announced an AU$80 million (US$52.1 million) capital raise that consists of a AU$50 million placement and a AU$30 million entitlement offer to eligible shareholders to fund clinical programs for lead candidate eftilagimod (IMP-321, efti), a lymphocyte activation gene-3 (LAG-3) fusion protein and major histocompatibility complex class II agonist that stimulates both innate and adaptive immunity for treating cancer.
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